Renal Cancer: In Vitro Models and Animal Tumors
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 53)
Model systems for human tumors are necessary tools of basic and clinically related research that can not be carried out in humans. It is desirable that these models reflect the properties of the human tumor as closely as possible. Before assuming that results obtained with a tumor model are relevant to the management of patients, a model system has to be characterized, and the similarity of the model with the human situation has to be firmly established. In the case of human renal carcinoma (RC) research with tumor models could be oriented in the directions indicated in this diagram: Prior to considering treatment studies, characterization is an obligatory step. There should be correlation with the basic research that can be conducted with established models.
KeywordsRenal Cell Carcinoma Soft Agar Renal Carcinoma Syrian Golden Hamster Human Renal Cell Carcinoma
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Unable to display preview. Download preview PDF.
- 7.B. Lucke, A Neoplastic Disease of the Kidney of the Frog Rana Pipiens, Amer. J. Cancer 20:352 (1934).Google Scholar
- 9.G. Weber, Enzymatic Programs of Human Renal Adenocarcinoma, in: “Renal Adenocarcinoma,” G. Sufrin and S.E. Beckley, eds., UICC technical Report Series, Geneva (1980), p.44.Google Scholar
- 10.G. Sufrin, Spontaneous, Hormonal and Chemically Induced Animal Models of Renal Adenocarcinoma, in:”Renal Adenocarcinoma,” G. Sufrin and S.A. Beckley, eds., UICC Technical Report Series, Geneva Vol. 49:2 (1980).Google Scholar
- 12.W. Hohn and F.H. Schroder, Renal Cell Carcinoma. Two New Cell Lines and a Serially Transplantable Nude Mouse Tumor (NC 65), Invest. Urol. 16:106 (1978).Google Scholar
- 13.J.W. Day and D.F. Paulson, In vivo Confirmation of in vitro Chemotherapy Testing. Abstract, American Urological Association, No. 134 (1980).Google Scholar
- 14.R.V. Clayman, M. Dempsey, and R. Gonzalez, Cholesterol Accumulation in Renal Cell Carcinoma: A clinical Assessment. Abstract, American Urological Association, No. 137 (1980).Google Scholar
- 16.J.E. Pontes, M Goldrosen, and G.P. Murphy, Immunological Response to Tumor Ischemia in a Murine Renal Cell Carcinoma, Abstracts, American Urological Association, No. 420 (1981).Google Scholar
- 19.F.H. Schröder and K. Oishi, Renal Adenocarcinoma-Immuno-Deficient Systems, in: “Renal Adenocarcinoma,” G. Sufrin and S.A. Beckley, eds., UICC Technical Report Series, Geneva Vol. 49:114 (1980)Google Scholar
- 20.G. Popelier, R. Geers, G. Verdonck, F.H. Schröder, and W. Höhn, The Biochemical Profile of the Tissue of a Human Renal Cell Xenograft on the Nude Mouse (NC 65) Compared to the Profile of Human Renal Cortex (RCX) and Renal Cell Carcinoma (RCC), Urol. Res. 8:233, No. 4 (1980)Google Scholar
- 21.A Hagemeyer, W Höhn, and E.M.E. Smit, Cytogenetic Analysis of Human Renal Cell Carcinoma Cell Lines of Common Origin. (NC 65)., Cancer Res. 39:4462 (1979).Google Scholar
- 23.M.M. Lieber and J.S. Kovach, Drug Sensitivity Testing in vitro with a Soft Agar Stem Cell Colony Assay. Abstracts, American Urological Association, No. 133 (1980).Google Scholar
- 24.H.E. Bogden, A Rapid Screening Method for Testing Chemotherapeutic agents against Human Tumor Xenografts, in:”Symposium on the use of Athymic “Nude” Mice in Cancer Research,” D.H. Houckens and A.A. Ojevera, eds., New York (1978).Google Scholar
- 27.S. Shrivastav and D.F. Paulson, In Vitro Chemotherapy Testing of Transitional Cell Carcinoma, Invest. Urol. 17:395 (1978).Google Scholar
- 28.M.F. Sarosdy, D.L. Lamm, H.M. Radwin and D.D. von Hoff, In vitro Clonal Assay and Chemosensitivity Testing of Human Urologic Malignancies. Abstract, American Urological Association, No.4l8 (1981).Google Scholar
- 29.M.M. Lieber and J.S. Kovach, Soft Agar Clonogenic Assay for Primary Human Renal Carcinoma: In vitro Chemotherapeutic Drug Sensitivity Testing. Abstract, Americal Urological Association, No. 531 (1981).Google Scholar
- 30.P. Belitsky, T. Ghose, K. Vaughan, H. Nolido, and T. van Zoost, Inhibition of a Mouse Renal Carcinoma with Adriamycin Linked Anti-renal Carcinoma Antibody. Abstracts, American Urological Association, No. 421 (1981).Google Scholar
© Springer Science+Business Media New York 1983