Aetiology of Kidney Tumours

  • M. Pavone-Macaluso
  • G. B. Ingargiola
  • M. Lamartina
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 53)


Surveys of possible aetiological factors were made by one of us in 1963 and in 1967 (1,2), reviewing 441 articles hoping to find some clues to the causes of tumours of the kidney.


Renal Cell Carcinoma Flame Retardant Renal Tumour Renal Cancer Renal Pelvis 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    M. Pavone-Macaluso, L’étiologie et la pathogénie des tumeurs du rein. Les tumeurs expérimentales, Gazette Médicale de France 70:1143 (1963).PubMedGoogle Scholar
  2. 2.
    M. Pavone-Macaluso, Etiology of kidney tumors, in: “Renal Neoplasia”, J.S. King, ed., Little, Brown and Co., Boston (1967) p 247.Google Scholar
  3. 3.
    H. Ishiguro, D. Beard, J.R. Sommer, U. Heine, G. de Thé and J.W. Beard, Multiplicity of cell response to the BAI strain A (myeloblastosis) avian tumor virus. I: Nephroblastoma (Wilms’ tumor) gross and microscopic pathology, J. Nat. Cancer Inst. 29:1 (1962).Google Scholar
  4. 4.
    R. Eker, Familial renal adenoma in Wistar rats, Acta Path. Microbiol. Scand. 34:554 (1954).PubMedCrossRefGoogle Scholar
  5. 5.
    H.A. Horn and H.L. Stewart, A review of some spontaneous tumors in non-inbred mice, J. Nat. Cancer Inst. 13:591 (1952).PubMedGoogle Scholar
  6. 6.
    A. Claude, Adénocarcinome rénal endémique chez une souche de souris, Rev. Franc. Etudes Clin. Biol. 3:261 (1958).PubMedGoogle Scholar
  7. 7.
    J.A. Fortner, A.G. Mahy and R.S. Cotron, Transplantable tumors of the Syrian golden hamster. Part II: Tumors of the hematopoietic tissues, genito-urinary organs, mammary glands and sarcomas, Cancer Res. 21:199 (1961).PubMedGoogle Scholar
  8. 8.
    G. Patoir, Les tumeurs du rein en fer a cheval, J. Urol. Méd. Chir. 65:799 (1959).Google Scholar
  9. 9.
    A. Tallarigo, Su un raro caso di associazione tra rene policistico e tumore ipernefroma, Riv. Anat. Patol. Oncol. 3:510 (1950).Google Scholar
  10. 10.
    A. Puigvert, Polykystose renale et cancer bilateral, J. Urol. Méd. Chir. 64:30 (1958).Google Scholar
  11. 11.
    J.B. Beckwith, Multilocular renal cysts and cystic renal tumors, Amer. J Roentgenol. 136:435 (1981).CrossRefGoogle Scholar
  12. 12.
    R. Churalla, Fenomeni endocrini nell’ ipernefroma del rene, Urologia 20:9 (1953).Google Scholar
  13. 13.
    A.F. Kantor, Current concepts of epidemiology and etiology of primary renal cell carcinoma, J. Urol. 117:415 (1972).Google Scholar
  14. 14.
    G. Sufrin, Spontaneous, hormonal and chemically induced animal models of renal adenocarcinoma, in: “Renal Adenocarcinoma” G. Sufrin and S.A. Beckley, eds., U.I.C.C, Geneva (1980) p 2.Google Scholar
  15. 15.
    F. Berrino, Epidemiología e patogenese dei tumori maligni del rene: Presented at the 22nd course of the Istituto Nazionale Tumori, Milano, 1981 (to be published).Google Scholar
  16. 16.
    R.A.M. Case, Mortality from cancer of the kidney in England and Wales with data from other countries for comparison in: “Tumours of the Kidney and Ureter”, E. Riches, ed., Livingstone, Edinburgh, (1964) p 1.Google Scholar
  17. 17.
    Redmond, J. Occ. Med. 9:277 (1965) quoted by Berrino (15).Google Scholar
  18. 18.
    H.L. Ratcliffe, Familial occurence of renal carcinoma in Rhesus Monkey (macaca mulatta), Amer. J. Pathol. 16:619 (1940).Google Scholar
  19. 19.
    L.F. Brinton, Hypernephroma: familiar occurrence in one family, J. Amer. Med. Assoc. 173:889 (1960).CrossRefGoogle Scholar
  20. 20.
    S.M. Goldman, Renal cell carcinoma diagnosed in three generations of a single family, South Med. J. 72:1457 (1979).PubMedCrossRefGoogle Scholar
  21. 21.
    A.J. Cohen, F.B. Li, S. Berg, D.J. Marchetto, S. Tsai, S.C. Jacobs and R.S. Brown, Hereditary renal cell carcinoma associated with a chromosome translocation, New Engl. J. Med. 301:592 (1979).PubMedCrossRefGoogle Scholar
  22. 22.
    J.P. Griffin, G.V. Hughes and W.B. Peeling, A survey of the familial incidence of adenocarcinoma of the kidney, Brit. J. Urol. 39:63 (1967).PubMedCrossRefGoogle Scholar
  23. 23.
    E.R. Reddy, Bilateral renal cell carcinoma, Unusual occurrence in three members of one family, Brit. J. Radiol. 54:8 (1981).PubMedCrossRefGoogle Scholar
  24. 24.
    V.J. Rosen and L.J. Cole, Accelerated induction of kidney neoplasms in mice after X-radiation and unilateral nephrectomy, J. Nat. Cancer Inst. 28:1031 (1962).PubMedGoogle Scholar
  25. 25.
    W. Freidrich, Hypernephroides Carcinom nach Thorotrastanwendung und eosinophiles Adenom der Hypophyse, Krebsforsch 63:456 (1960).CrossRefGoogle Scholar
  26. 26.
    S. Beckley, Viral models of renal adenocarcinoma, in: “Renal Adenocarcinoma”, G. Sufrin and S.A. Beckley, eds., U.I.C.C. Geneva (1980) p 28.Google Scholar
  27. 27.
    B. Lücke, Carcinoma in the leopard frog. Its probable causation by a virus, J. Exp. Med. 68:457 (1938).PubMedCrossRefGoogle Scholar
  28. 28.
    A. Granoff, Herpes virus and the Lucké tumor, Cancer Res. 33:1431 (1973).PubMedGoogle Scholar
  29. 29.
    R. Cocchiara, G. Tarro, G. Flaminio, M. Di Gioia, R. Smeraglia and D. Geraci, Purification of herpes simplex virus tumor associated antigen from human kidney carcinoma, Cancer 46:1594 (1980).PubMedCrossRefGoogle Scholar
  30. 30.
    H. Reznick-Schuller, Carcinogenic effect of diethylstilbestrol in male Syrian golden hamsters and European hamsters, J. Nat. Cancer Inst. 62:1083 (1979).Google Scholar
  31. 31.
    M.C. Rivière, I. Chouroulinkov and M. Guerin, Action inhibante de la désoxycorticosterone sur la production de tumeurs rénales chez le hamster mâle traité par un oestrogen, C.R. Soc. Biol. 154:1415 (1960).Google Scholar
  32. 32.
    H.J.G. Bloom, C.E. Dukes and B.C.V. Mitchley, Hormone-dependent tumours of the kidney: I. The oestrogen-induced renal tumour of the Syrian hamster. Hormone treatment and possible relationship to carcinoma of the kidney in man, Brit. J. Cancer 17:611 (1963).PubMedCrossRefGoogle Scholar
  33. 33.
    G. Concolino, A. Marocchi, C Conti, R. Tenaglia, F. di Silverio and U. Bracci, Human renal carcinoma as a hormone-dependent tumour, Cancer Res. 38:4340 (1978).PubMedGoogle Scholar
  34. 34.
    F. di Fronzo, Estrogen receptors in renal carcinoma, Eur. Urol. 6:307 (1980).PubMedGoogle Scholar
  35. 35.
    M. Pignalosa and M. Fernandez, “Tumori del Rene”, L. Capelli, Bologna (1938) p 37.Google Scholar
  36. 36.
    O. Bantley and G.T. Hultquist, Spontaneous regression of hypernephromas, Acta Pathol. Microbiol. Scand. 27:448 (1950).CrossRefGoogle Scholar
  37. 37.
    W.K. Kerr, M. Barkin, J.A.D. Todd and Z. Menczyk, Hypernephroma associated with elevated levels of bladder carcinogens in the urine: case report, Brit. J. Urol. 35:263 (1963).PubMedCrossRefGoogle Scholar
  38. 38.
    G. Reznick, J.M. Ward, J.F. Hardisty and R. Russfield, Renal carcinogenic and nephrotoxic effects of the flame retardant Tris (2,2 -dibromopropyl) phosphate in F344 rats and (C57BL/(6N × C3H/HeN) F1 mice, J. Nat. Cancer Inst. 63:205 (1979).Google Scholar
  39. 39.
    S.S. Sternberg, F.S. Philips and A.P. Cronic, Renal tumors and other lesions in rats following a single intravenous injection of daunomycin, Cancer Res. 32:1029 (1972).PubMedGoogle Scholar
  40. 40.
    L. Kilham, R.J. Low, S.F. Conti and F.D. Dallenbach, Intranuclear inclusions and neoplasms in the kidneys of wild rats, J. Nat. Cancer Inst. 29:863 (1962).PubMedGoogle Scholar
  41. 41.
    W. Gusek, Die Ultrastruktur Cycasin induzienter Nierenadenome, Virchows Arch. Abt. A. Pathol. 365:221 (1975).Google Scholar
  42. 42.
    D. Poggiolini, ed., Cloroformio — Bollettino d’informazione sui farmaci, Ministero della Sanita 4 (11):5 (1980).Google Scholar
  43. 43.
    R. de Veré White, A spontaneously arising renal cancer in the rat. A model for drug sensitivity studies, in: “Cancer of the Prostate and Kidney,” P.H. Smith and M. Pavone-Macaluso, eds., Plenum Press, London and New York (1982).Google Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • M. Pavone-Macaluso
    • 1
  • G. B. Ingargiola
    • 1
  • M. Lamartina
    • 1
  1. 1.Institute of UrologyUniversity of PalermoItaly

Personalised recommendations