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Preliminary Results of Two Eortc Randomized Trials in Previously Untreated Patients with Advanced T3 — T4 Prostatic Cancer

  • M. de Pauw
  • S. Suciu
  • R. Sylvester
  • P. H. Smith
  • M. Pavone-Macaluso
  • EORTC Genito-Urinary Tract Cooperative Group
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 53)

Abstract

At the end of 1976 and the beginning of 1977 respectively, the EORTC Genito-Urinary Tract Cancer Cooperative Group started two randomized phase III protocols in previously untreated patients with advanced T3–4 prostatic cancer (1–3). The first trial, 30762, compared Stilboestrol and Estracyt, while the second, 30761, was a randomized comparison of Stilboestrol, Cyproterone Acetate and Medroxyprogesterone Acetate. Both trials have now been closed to patient entry and the principal endpoints of the studies analyzed. This paper will present the interim results which have emerged from these two studies.

Keywords

Bone Metastasis Cardiovascular Death Prostatic Tumour Medroxyprogesterone Acetate Cyproterone Acetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    M. Pavone-Macaluso, F. Lund, J.H. Mulder, P.H. Smith, M. de Pauw, R. Sylvester, and EORTC Urological Group, EORTC Protocols in Prostatic Cancer, An Interim Report, Scand. J. Urol. Nephrol. Suppl. 55: 163 (1980).Google Scholar
  2. 2.
    P.H. Smith, A. Akdas, M.K. Mason, B. Richards, M. Robinson, M. de Pauw, and R. Sylvester, Hormone therapy in prostatic cancer, Acta. Urol. Belg. 48: 282 (1980).Google Scholar
  3. 3.
    M. de Pauw, C. Bouffioux, J. Casselman, C. Schulman, B. Vergison, and L. Denis, The European Organisation for Research on Treatment of Cancer. Genito-Urinary Tract Cancer Cooperative Group, Acta. Urol. Belg. 48: 285 (1980).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • M. de Pauw
    • 1
  • S. Suciu
    • 1
  • R. Sylvester
    • 1
  • P. H. Smith
    • 2
  • M. Pavone-Macaluso
    • 3
  • EORTC Genito-Urinary Tract Cooperative Group
  1. 1.EORTC Data CenterBrusselsBelgium
  2. 2.St. James’s University HospitalLeedsUK
  3. 3.University of PalermoItaly

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