On the Methodology of Controlled Clinical Trials
A wide and varied literature exists on the appropriate methodology that one should employ in the design and analysis of clinical trials. As many concepts are somewhat controversial in nature and not widely accepted or understood by many researchers, this paper will present a very general overview of the underlying principles involved in the design and analysis of clinical trials.
KeywordsControl Clinical Trial Prostatic Cancer Patient Cancer Clinical Trial Centralize Randomization Varied Literature
Unable to display preview. Download preview PDF.
- 1.M. Staquet, R. Sylvester and C. Jasmin, Guidelines for the preparation of EORTC cancer clinical trial protocols, Europ. J. Cancer, 16:871 (1980).Google Scholar
- 2.WHO Handbook for Reporting Results of Cancer Treatment, WHO Offset Publication No. 48, World Health Organization, Geneva (1979).Google Scholar
- 3.D. L. Kisner and R. J. Sylvester, Guidelines for Reporting Cancer Clinical Trials. Colloque INSERM/Direction de la Pharmacie, Evaluation des Medicaments, INSERM, Paris, Vol 96:477 (1980).Google Scholar
- 5.R. Peto, M. C. Pike, P. Armitage, N. E. Breslow, D. R. Cox, S. V. Howard, N. Mantel, K. McPherson, J. Peto and P. G. Smith, Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples, Brit. J. Cancer 35:1 (1977).PubMedCrossRefGoogle Scholar
- 6.R. Sylvester, D. Machin and M. Staquet, A comparison of the alternative methods of calculating survival curves arising from Clinical Trials. Biomedicine Special Issue, 28:49 (1978).Google Scholar