On the Methodology of Controlled Clinical Trials

  • R. Sylvester
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 53)


A wide and varied literature exists on the appropriate methodology that one should employ in the design and analysis of clinical trials. As many concepts are somewhat controversial in nature and not widely accepted or understood by many researchers, this paper will present a very general overview of the underlying principles involved in the design and analysis of clinical trials.


Control Clinical Trial Prostatic Cancer Patient Cancer Clinical Trial Centralize Randomization Varied Literature 


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    R. Sylvester, D. Machin and M. Staquet, A comparison of the alternative methods of calculating survival curves arising from Clinical Trials. Biomedicine Special Issue, 28:49 (1978).Google Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • R. Sylvester
    • 1
  1. 1.EORTC Data CentreBrusselsBelgium

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