Animal Models in Prostatic Cancer
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 53)
Many aspects of human cancer can only be investigated properly by the use of suitable experimental model systems. In the field of prostatic cancer such model systems are relatively scarce. For any model system, it is essential that its properties reflect those of the human situation as closely as possible. Isaacs and Coffey (1) have published a list of requirements that should be fulfilled by an ideal animal model for prostatic cancer. Some of the most important properties of the ideal prostatic cancer model are:
It is not likely that the ideal model does exist. However, each model should be characterized extensively, especially with respect to the points just mentioned, before treatment studies are performed.
histology similar to human prostatic cancer
metastatic patterns to lymph nodes and bone
slow growth rate
initial response to hormonal manipulation
ultimate relapse to hormone insensitive state
KeywordsNude Mouse Human Prostatic Cancer Prostatic Adenocarcinoma Dorsal Lobe PC82 Tumor
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer Science+Business Media New York 1983