Advertisement

Animal Models in Prostatic Cancer

  • J. C. Romijn
  • G. J. v. Steenbrugge
  • M. A. Blankenstein
  • F. H. Schröder
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 53)

Abstract

Many aspects of human cancer can only be investigated properly by the use of suitable experimental model systems. In the field of prostatic cancer such model systems are relatively scarce. For any model system, it is essential that its properties reflect those of the human situation as closely as possible. Isaacs and Coffey (1) have published a list of requirements that should be fulfilled by an ideal animal model for prostatic cancer. Some of the most important properties of the ideal prostatic cancer model are:
  1. (i)

    histology similar to human prostatic cancer

     
  2. (ii)

    metastatic patterns to lymph nodes and bone

     
  3. (iii)

    slow growth rate

     
  4. (iv)

    initial response to hormonal manipulation

     
  5. (v)

    ultimate relapse to hormone insensitive state

     
It is not likely that the ideal model does exist. However, each model should be characterized extensively, especially with respect to the points just mentioned, before treatment studies are performed.

Keywords

Nude Mouse Human Prostatic Cancer Prostatic Adenocarcinoma Dorsal Lobe PC82 Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    J.T. Isaacs and D.S. Coffey, Spontaneous animal models for prostate cancer, in: “Prostate Cancer,” UICC Technical Report Series, Vol. 48, D.S. Coffey and J.T. Isaacs, eds, Geneva, 195–219 (1979).Google Scholar
  2. 2.
    A. Rivenson and J. Silverman, The prostatic carcinoma in laboratory animals. A bibliographic survey from 1900 to 1977, Invest. Urol. 16:468–472 (1979).PubMedGoogle Scholar
  3. 3.
    W.F. Dunning, Prostate cancer in the rat, National Cancer Institute Monograph 12:351–369 (1963).PubMedGoogle Scholar
  4. 4.
    A.J. Claflin, E.C. McKinney and M.A. Fletcher, The Dunning R3327 prostate adenocarcinoma in the Fischer-Copenhagen F1 rat: a useful model for immunological studies, Oncology 34:105–109 (1977).PubMedCrossRefGoogle Scholar
  5. 5.
    J.T. Isaacs, W.D.W. Heston, R.M. Weissman and D.S. Coffey, Animal models of the hormone-sensitive and insensitive prostatic adenocarcinomas, Dunning R3327-H, R3327-HI and R3327-AT, Cancer Res. 38:4353–4359 (1978).PubMedGoogle Scholar
  6. 6.
    G. Seman, G. Meyers, J.M. Bowen and L. Dmochowski, Histology and ultrastructure of the R3327 C-F transplantable prostate tumor of Copenhagen-Fischer rats, Invest. Urol. 16:231–236 (1978).PubMedGoogle Scholar
  7. 7.
    J.K. Smolev, D.S. Coffey and W.W. Scott, Experimental models for the study of prostatic adenocarcinoma, J. Urol. 118:216–220 (1977).PubMedGoogle Scholar
  8. 8.
    J.K. Sniolev, W.D.W. Heston, W.W. Scott and D.S. Coffey, Characterization of the Dunning R3327H prostatic adenocarcinoma: an appropriate animal model for prostatic cancer, Cancer Treatment Rep. 61:273–287 (1977).Google Scholar
  9. 9.
    R.M. Weismann, D.S. Coffey and W.W. Scott, Cell kinetic studies of prostatic cancer: adjuvant therapy in animal models, Oncology 34:133–137 (1977).CrossRefGoogle Scholar
  10. 10.
    B.R. Rao, A. Makeff, C. Eaton and W.D.W. Heston, Establishment and characterization of an in vitro clonogenic cell assay for the R3327-AT Copenhagen rat prostatic tumor, Cancer Res. 38:4431–4439 (1978).PubMedGoogle Scholar
  11. 11.
    J.T. Isaacs, W.B. Isaacs and D.S. Coffey, Models for development of non-receptor methods for distinguishing androgen-sensitive and -insensitive prostatic tumors, Cancer Res. 39:2652–2659 (1979).PubMedGoogle Scholar
  12. 12.
    D.M. Lubaroff, L. Cranfield and C.W. Reynolds, The Dunning tumors, in: “Models for Prostate Cancer,” G.P. Murphy, ed., Alan R. Liss, Inc. New York, 243–263 (1980).Google Scholar
  13. 13.
    M. Pollard, Spontaneous prostate adenocarcinomas in aged germ-free Wistar rats, J. Natl. Cancer Inst. 51:1235–1241 (1973).PubMedGoogle Scholar
  14. 14.
    M. Pollard and P.H. Luckert, Transplantable metastasizing prostate adenocarcinomas in rats, J. Natl. Cancer Inst. 54: 643–649 (1975).PubMedGoogle Scholar
  15. 15.
    M. Pollard, The Pollard tumors, in: “Models for Prostate Cancer,” G.P. Murphy, ed., Alan R. Liss, Inc. New York, 293–302 (1980).Google Scholar
  16. 16.
    M. Pollard, C.F. Chang and P.H. Luckert, Investigations on prostatic adenocarcinomas in rats, Oncology 34:129–132 (1977).PubMedCrossRefGoogle Scholar
  17. 17.
    R.L. Noble, The development of prostatic adenocarcinoma in the Nb rat following prolonged sex hormone administration, Cancer Res. 37:1929–1933 (1977).PubMedGoogle Scholar
  18. 18.
    R.L. Noble, Development of androgen-stimulated transplants of Nb rat carcinoma of the dorsal prostate and their response to sex hormones and tamoxifen, Cancer Res. 40:3551–3554 (1980).PubMedGoogle Scholar
  19. 19.
    R.L. Noble, Sex steroids as a cause of adenocarcinoma of the dorsal prostate in Nb rats, and their influence on the growth of transplants, Oncology 34:138–141 (1977).PubMedCrossRefGoogle Scholar
  20. 20.
    R.L. Noble, Hormonal control of growth and progression in tumors of Nb rats and a theory of action, Cancer Res. 37:82–94 (1977).PubMedGoogle Scholar
  21. 21.
    J.R. Drago, M.E. Gershwin, R.E. Maurer, R.K. Ikeda and D.E. Eckels, Immunobiology and therapeutic manipulation of heterotransplanted Nb rat prostate adenocarcinoma into congenitally athymic (nude) mice, J. Natl. Cancer Inst. 62: 1057–1066 (1979).PubMedGoogle Scholar
  22. 22.
    R.L. Noble, Production of Nb rat carcinoma of the dorsal prostate and response of estrogen-dependent transplants to sex hormones and tamoxifen, Cancer Res. 40:3547–3550 (1980).PubMedGoogle Scholar
  23. 23.
    K. Okada, F.H. Schröder, W. Jellinghaus, K.H. Wullstein and H.M. Heinemeyer, Human prostatic adenoma and carcinoma: transplantation of cultured cells and primary tissue fragments in nude mice, Invest. Urol. 13:395–403 (1976).PubMedGoogle Scholar
  24. 24.
    D.D. Mickey, K.R. Stone, H. Wunderli, G.H. Mickey, R.T. Vollmer and D.F. Paulson, Heterotransplantation of a human prostatic adenocarcinoma cell line in nude mice, Cancer Res. 37:4049–4058 (1977).PubMedGoogle Scholar
  25. 25.
    M.E. Kaighn, K.S. Narayan, Y. Ohnuki, J.F. Lechner and L.W. Jones, Establishment and characterization of a human prostatic carcinoma cell line (PC-3), Invest. Urol. 17:16–23 (1979).PubMedGoogle Scholar
  26. 26.
    J.S. Horoszewicz, S.S. Leong, M.T. Chu, M. Friedman, U. Kim, L.S. Chai, S. Kakita, S.A. Arya and A. A. Sandberg, A new model for studies on human prostatic carcinoma, Proc. AACR 20:212 (1979).Google Scholar
  27. 27.
    Y. Shimosato, T. Kameya, K. Nagai, S. Hirohashi, T. Koide, H. Hayashi and T. Nomura, Transplantation of human tumors in nude mice, J. Natl. Cancer Inst. 56:1251–1260 (1976).PubMedGoogle Scholar
  28. 28.
    M.A. Jones, G. Williams and A.J.S. Davies, Value of xenografts in the investigation of prostatic function: preliminary communication, J. Roy. Soc. Med. 73:708–712 (1980).PubMedGoogle Scholar
  29. 29.
    L.C.M. Reid and S. Shin, Transplantation of heterologous endocrine tumor cells in nude mice, in: “The Nude Mouse in Experimental and Clinical Research,” J. Fogh and B.C. Giovanella, eds., Academic Press, New York, 313–351 (1978).Google Scholar
  30. 30.
    W. Hoehn, F.H. Schroeder, J.F. Riemann, A.C. Jobsis and P. Hermanek, Human prostatic adenocarcinoma: some characteristics of a serially transplantable line in nude mice (PC82). The Prostate 1:95–104 (1980).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • J. C. Romijn
    • 1
  • G. J. v. Steenbrugge
    • 1
  • M. A. Blankenstein
    • 1
  • F. H. Schröder
    • 1
  1. 1.Erasmus UniversityRotterdamThe Netherlands

Personalised recommendations