Animal Models in Prostatic Cancer

  • J. C. Romijn
  • G. J. v. Steenbrugge
  • M. A. Blankenstein
  • F. H. Schröder
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 53)


Many aspects of human cancer can only be investigated properly by the use of suitable experimental model systems. In the field of prostatic cancer such model systems are relatively scarce. For any model system, it is essential that its properties reflect those of the human situation as closely as possible. Isaacs and Coffey (1) have published a list of requirements that should be fulfilled by an ideal animal model for prostatic cancer. Some of the most important properties of the ideal prostatic cancer model are:
  1. (i)

    histology similar to human prostatic cancer

  2. (ii)

    metastatic patterns to lymph nodes and bone

  3. (iii)

    slow growth rate

  4. (iv)

    initial response to hormonal manipulation

  5. (v)

    ultimate relapse to hormone insensitive state

It is not likely that the ideal model does exist. However, each model should be characterized extensively, especially with respect to the points just mentioned, before treatment studies are performed.


Nude Mouse Human Prostatic Cancer Prostatic Adenocarcinoma Dorsal Lobe PC82 Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • J. C. Romijn
    • 1
  • G. J. v. Steenbrugge
    • 1
  • M. A. Blankenstein
    • 1
  • F. H. Schröder
    • 1
  1. 1.Erasmus UniversityRotterdamThe Netherlands

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