Histochemical Determination of Androgen Binding Sites in Prostatic Adenocarcinoma: Clinical Correlation
The figure of 80% is classically quoted as the percentage of patients with advanced prostatic adenocarcinoma who respond at least initially to hormonal manipulation. At the present time there is no method of predicting whether a given patient will respond to such therapy. It is not unreasonable to hypothesize that those patients with androgen dependent tumors should have high levels of androgen binding sites. A non-immunologic histochemical method has been developed by Pertschuk (1,2,3,4,5) to measure androgen binding sites. The principal purpose of this report is to update the clinical trial we are currently conducting to determine whether or not the test can be used to predict response to hormonal manipulation.
KeywordsProstate Cancer Hormonal Manipulation Histochemical Technique Histochemical Detection Estrogen Binding
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- 1.L.P. Pertschuk, D.T. Zava, E. Gaetjens, R.J. Macchia, D.J. Brigati, and D.S. Kim, Detection of androgen and estrogen receptors in human prostatic carcinoma and hyperplasia by fluorescence microscopy, Res. Comm. Path. Pharmacol. 22:427 (1978).Google Scholar
- 3.L.P. Pertschuk, D.T. Zava, E.H. Tobin, D.J. Brigati, E. Gaetjens, R.J. Macchia, G.J. Wise, H.S. Wax, and D.S. Kim, Histochemical detection of steroid hormone receptors in the human prostate, in: “Prostate Cancer and Hormone Receptors,” G.P. Murphy and A.A. Sandberg, eds., Alan R. Liss, Inc., New York (1979).Google Scholar
- 5.L.P. Pertschuk, H.E. Rosenthal, R.J. Macchia, K.B. Eisenberg, J.G. Feldman, S.H. Wax, D.S. Kim, W.F. Whitmore, Jr., J.I. Abrahams, E. Gaetjens, G.J. Wise, H.W. Herr, J.P. Karr, G.P. Murphy, and A.A. Sandberg, Correlation of histochemical and biochemical analyses of androgen binding in prostatic cancer: relation to therapeutic response, Cancer, in press.Google Scholar
- 8.D.R. Gleason, Histologic grading and clinical staging of prostatic carcinoma, in: “Urologic Pathology: The Prostate,” M. Tannenbaum, ed., Lea and Febiger, Philadelphia (1977).Google Scholar