Histochemical Determination of Androgen Binding Sites in Prostatic Adenocarcinoma: Clinical Correlation

  • R. J. Macchia
  • L. P. Pertschuk
  • New York Prostate Binding Site Study Group
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 53)


The figure of 80% is classically quoted as the percentage of patients with advanced prostatic adenocarcinoma who respond at least initially to hormonal manipulation. At the present time there is no method of predicting whether a given patient will respond to such therapy. It is not unreasonable to hypothesize that those patients with androgen dependent tumors should have high levels of androgen binding sites. A non-immunologic histochemical method has been developed by Pertschuk (1,2,3,4,5) to measure androgen binding sites. The principal purpose of this report is to update the clinical trial we are currently conducting to determine whether or not the test can be used to predict response to hormonal manipulation.


Prostate Cancer Hormonal Manipulation Histochemical Technique Histochemical Detection Estrogen Binding 
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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • R. J. Macchia
    • 1
  • L. P. Pertschuk
    • 1
  • New York Prostate Binding Site Study Group
    • 1
  1. 1.Downstate Medical SchoolNew YorkUSA

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