The Present Status of Receptor Studies in Relation to Prostatic Cancer

  • H. J. de Voogt
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 53)


Research into androgen receptors in prostatic tissue started with the experimental work of Liao and Fang (1) and Bruchovsky and Wilson (2) in rats. They were able to identify the specific binding proteins for steroids, called receptors, in cytoplasm and nuclei of rat prostatic cells and they defined and confirmed their role in androgen metabolism of these cells.


Human Prostate Steroid Receptor Prostatic Tissue Benign Prostatic Hypertrophy Normal Prostatic Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    S. Liao and S. Fang, Receptor-proteins for androgens and the mode of action of androgens on gene transcription in rat ventral prostate, Vitam. Horm. 27:17 (1969).PubMedCrossRefGoogle Scholar
  2. 2.
    N. Bruchovsky and J.D. Wilson, The intranuclear binding of testosterone and 5α DHT by rat prostate, J. Biol. Chem. 243:5953 (1968).PubMedGoogle Scholar
  3. 3.
    S. Liao, C. Chen, R. Loor and R.A. Hüpatka, Androgen-sensitive protein in rat ventral prostate: a specific intracellular protein and secretory protein, in: “Steroid Receptors, Metabolism and Prostatic Cancer,” H.J. de Voogt and F.H. Schroeder, eds., Excerpta Medica, Amsterdam (1980).Google Scholar
  4. 4.
    P. Ekman, M. Snochowski, E. Dahlberg and J.A. Gustafsson, Steroid receptors in metastatic carcinoma of the human prostate, Eur. J. Cancer 15:257 (1979).PubMedGoogle Scholar
  5. 5.
    R.S. Hsu, R.G. Middleton and S. Fang, “Androgen Receptors in Human Prostate in Normal and Abnormal Growth of the Prostate,” M. Goland, ed., Charles Thomas, Springfield p 663–675 (1975).Google Scholar
  6. 6.
    W.I.P. Mainwaring and E.J.G. Milroy, Characterization of the specific androgen receptors in the human prostatic gland, J. Endocrinol. 57:371 (1973).PubMedCrossRefGoogle Scholar
  7. 7.
    K.J. Tveter, O. Unjhem, A. Attramadal, A. Aakvaag and V. Hansson, Androgenic receptors in rat and human prostate, Adv. Biosc. 7:193 (1981).Google Scholar
  8. 8.
    M. Krieg, W. Bartsch, W. Janssen and K.D. Voigt, A comparative study of binding, metabolism and endogenous levels of androgens in normal, hyperplastic, and carcinomatous human prostate, J. Steroid. Bioch. 11:615 (1979).CrossRefGoogle Scholar
  9. 9.
    J.B. Murphy, R.C. Emmott, L.L. Hicks and P.C. Walsh, Estrogen receptors in the human prostate, seminal vesicle, epididymis, testis, and genital skin: A marker for estrogen-responsive tissues? J. Clin. Endocrinol. Metab. 50:938 (1980).PubMedCrossRefGoogle Scholar
  10. 10.
    R.K. Wagner, Extracellular and intracellular steroid binding proteins, Acta Endocrinologica. Suppl. 218 (1978).Google Scholar
  11. 11.
    C. Bonne and J.P. Raynaud, Assay of androgen binding sites by exchange with R 1881, Steroids 26:227 (1975).PubMedCrossRefGoogle Scholar
  12. 12.
    A.S. Shain and R.W. Boesel, Human prostate steroid hormone receptor quantitation, Invest. Urol. 16:169 (1978).Google Scholar
  13. 13.
    D.A.N. Sirrett and J.K. Grant, Androgen binding in cytosols and nuclei of human hyperplastic prostatic tissue, J. Endocrinol. 77:101 (1978).CrossRefGoogle Scholar
  14. 14.
    G. Bartsch and H.P. Rohr, Ultrastructural sterology: a new approach to the study of prostatic function, Invest. Urol. 14:301 (1977).PubMedGoogle Scholar
  15. 15.
    H.J. de Voogt and P.G. Dingjan, Is there a place for assay of cytoplasmic steroid receptors in the endocrine treatment of prostatic cancer? in: “Steroid Receptors, Metabolism and Prostatic Cancer,” H.J. de Voogt and F.H. Schroeder, eds., Excerpta Medica, Amsterdam (1980).Google Scholar
  16. 16.
    F.H. Schroeder, K. Oishi and H.M. Schweikert, The application of cell culture techniques to human prostatic carcinoma, UICC Technical Report Series, 48:145 (1979).Google Scholar
  17. 17.
    J.E. McNeal, New morphologic findings relevant to the origin and evolution of carcinoma of the prostate and BPH, UICC Technical Report Series, 48:34 (1979).Google Scholar
  18. 18.
    A. Martelli, M. Soli, E. Bercovich, G. Prodi, S. Grilli, C. De Giovanni and M.C. Galli, Correlation between clinical response to antiandrogenic therapy and occurrence of receptors in human prostatic cancer, Urology 16:245 (1980).PubMedCrossRefGoogle Scholar
  19. 19.
    I. Nenci, Cytochemistry of steroid-cell interactions, Abstract Internat. Symp. Perspectives in Steroid Receptor Research, Sorrento (1979).Google Scholar
  20. 20.
    L.P. Pertschuk, E.H. Tobin, P. Tanapat, E. Gaetjens, A.C. Carter, N.D. Bloom, R.J. Macchia and K. Byer Eisenberg, Histochemical analysis of steroid hormone receptors in breast and prostatic carcinoma, J. Histochem. and Cytochem. 28:799 (1980).CrossRefGoogle Scholar
  21. 21.
    W.B. Dandliker, R.J. Brawn, M.L. Hsu, P.N. Brawn, J. Levin, C.Y. Meyers and V.M. Kolb, Investigation of hormone-receptor interaction by means of fluorescence labelling, Cancer Research 38:4214 (1978).Google Scholar
  22. 22.
    W.I.P. Mainwaring, Steroid receptors and the regulation of transcriptional events in the prostate, UICC Technical Report Series 48:126 (1979).Google Scholar
  23. 23.
    B.R. Rao, G. Fry and M.J. Alsup, Prostatic tumor cells surviving estrogen treatment may become estrogen-adapted, Abstract Endocrine Society Meeting (and personal communication) (1981).Google Scholar
  24. 24.
    R.L. Noble, Sex steroids as a cause of adenocarcinoma of the dorsal prostate in Nb rats, and their influence on the growth of transplants, Oncology 34:138 (1977).PubMedCrossRefGoogle Scholar
  25. 25.
    D.S. Coffey and J.T. Isaacs, Experimental concepts in the design of new treatments for human prostate cancer, UICC Technical Report Series 48:233 (1979).Google Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • H. J. de Voogt
    • 1
  1. 1.Free University HospitalAmsterdamThe Netherlands

Personalised recommendations