Pulmonary and Osseous Metastases in Prostatic Cancer: Methods of Quantitative Assessment

  • D. P. Byar
  • J. A. Hovsepian
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 53)


The extent of bone and lung metastases in each of eight sites was rated on a semi-quantitative scale using pretreatment films for 102 patients with known metastases at diagnosis. A statistical analysis revealed significant correlation between shortened patient survival and a combination of the number of sites involved and the extent of involvement in those sites. Correlations were also identified with acid phosphatase, pain and performance ratings, but not with tumor grade. Examination of several films for patients treated with endocrine therapy showed that some patients who ultimately show improvement may initially show pseudo-progression.


Bone Metastasis Acid Phosphatase Lung Metastasis True Progression Serial Film 
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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • D. P. Byar
    • 1
  • J. A. Hovsepian
    • 2
  1. 1.National Cancer InstituteBethesdaUSA
  2. 2.Stanford University School of MedicineCaliforniaUSA

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