Studies of Acid Phosphatase in Prostatic Cancer
Various analyses of data gathered in the VACURG studies demonstrate that the extent of elevation of the pre-treatment acid phosphatase correlates with the probability of having detectable metastases and with survival. Patients with increased acid phosphatase but without evidence of metastases have a worse prognosis than patients with normal acid phosphatase and no metastases. For patients in stages I and II treated with radical prostatectomy, even values in the normal range were correlated with time until progression of tumor. These findings suggest that increased acid phosphatase values probably represent undetected metastases.
KeywordsAcid Phosphatase Radical Prostatectomy Prostate Gland Prostatic Acid Phosphatase Immunological Method
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- 5.D.P. Byar, Contributions of the Veterans Administration Cooperative Urological Research Group Studies to our Understanding of Prostatic Cancer and its Treatment, in “Urologic Pathology: The Prostate, M. Tannenbaum (ed), Lea and Febiger, New York, (1977) p. 241.Google Scholar