Epithelium and Stroma in Prostatic Cancer and Hyperplasia
The normal morphogenesis and cytodifferentiation of rodent prostatic epithelium is strongly dependent on the continuous association with mesenchymal cells of proper (i.e. urogenital) origin (1,2). The inductive capacity of urogenital stroma has been tested on different epithelia, and it was found that, in the presence of androgens, integumental epithelium was transformed by urogenital stroma into a glandular epithelium characteristic of the source of the stroma (1,3). Moreover, adult bladder epithelium could be induced to form prostate-like acini by embryonic stroma of urogenital origin (3)- From these observations McNeal (4) hypothesized that the formation of prostatic acini during the development of benign prostatic hyperplasia may be the result of a re-expression of embryonic inductive capacity. Cunha et al. (5) summarized the prerequisites for prostatic development to be i) the presence of androgens; ii) the presence of “inductive” stroma and iii) the ability of the epithelium to respond to the inductive influences.
KeywordsAndrogen Receptor Benign Prostatic Hyperplasia Prostatic Carcinoma Prostatic Acid Phosphatase Prostatic Epithelium
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- 6.W.I.P. Mainwaring, “The Mechanism of Action of Androgens,” Springer-Verlag, New York (1977).Google Scholar
- 8.M. Menon, C.E. Tananis, M.G. McLoughlin, and P.C. Walsh, Androgen receptors in human prostatic tissue-review, Cancer Treatment Rep. 61:265 (1977).Google Scholar
- 14.J.C. Romijn, K. Oishi, J. Bolt-de Vries, H.U. Schweikert, E. Mulder, and F.H. Schröder, Androgen metabolism and androgen receptors in separated epithelium and stroma of the human prostate, in:”Steroid Receptors, Metabolism and Prostatic Cancer,” F.H. Schröder and H.J. de Voogt, eds., Exerpta Medica, Amsterdam, (1980) p. 134.Google Scholar
- 18.T.G. Pretlow, M.G. Brattain, and J.I. Kreisberg, Separation and characterization of epithelial cells from prostates and prostatic carcinomas: a review, Cancer Treatment Rep. 61:157 (1977).Google Scholar
- 19.K. Oishi, J.C. Romijn, and F.H. Schröder, Cell separation and characterization of epithelial cells from human benign prostatic hyperplasia. The prostate, In press, (1981).Google Scholar
- 22.D.S. Coffey, The biochemistry and physiology of the prostate and seminal vesicles, in:”Campbells Urology,” 4th edition, H. Harrison, R.F. Gittes, A.D. Perlmutter, T.A Stamey, and P.C. Walsh, eds., Saunders, Philadelphia, (1978), Vol.1, p. 161.Google Scholar
- 25.H.R. Herschman, Prostatic acid phosphatase and cancer, T.I.B.S. 5:82 (1980).Google Scholar
- 27.M.M. Webber, In vitro models for prostatic cancer, in: ”Models for Prostatic Cancer,” G.P. Murphy, ed., Progr.clin.biol.Res. 37, Alan R. Liss, New York, (1980), p. 133.Google Scholar
- 30.J.C. Romijn, K. Oishi, and F.H. Schröder, Investigations on separated epithelium and stroma of human prostatic tissue, The Prostate 1:118 (1980).Google Scholar
- 32.F.K. Habib, A.L. Tesdale, G.D. Chisholm, and A. Busuttil, Prostatic retropubic and transurethral specimens. A comparison of androgen metabolism in the respective stromal and epithelial components, The Prostate 1:117 (1980).Google Scholar
- 35.H.U. Schweikert, H.J. Hein, J.C. Romijn, and F.H. Schröder, Testosterone metabolism of fibroblasts grown from prostatic carcinoma, benign prostatic hyperplasia and skin fibroblasts. Invest, Urol. In Press (1981).Google Scholar
- 38.L.P. Pertschuk, D.T. Zava, E.H. Tobin, D.J. Brigati, E. Gaetjens, R.J. Macchia, G.J. Wise, H.S. Wax, and D.S. Kim, Histochemical detection of steroid hormone receptors in the human prostate, in:”Prostate Cancer and Hormone Receptors,” G.P. Murphy and A.A. Sandberg, eds., Alan R. Liss, New York, (1980), p. 113.Google Scholar