Epithelium and Stroma in Prostatic Cancer and Hyperplasia

  • M. A. Blankenstein
  • J. C. Romijn
  • G. J. van Steenbrugge
  • F. H. Schröder
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 53)


The normal morphogenesis and cytodifferentiation of rodent prostatic epithelium is strongly dependent on the continuous association with mesenchymal cells of proper (i.e. urogenital) origin (1,2). The inductive capacity of urogenital stroma has been tested on different epithelia, and it was found that, in the presence of androgens, integumental epithelium was transformed by urogenital stroma into a glandular epithelium characteristic of the source of the stroma (1,3). Moreover, adult bladder epithelium could be induced to form prostate-like acini by embryonic stroma of urogenital origin (3)- From these observations McNeal (4) hypothesized that the formation of prostatic acini during the development of benign prostatic hyperplasia may be the result of a re-expression of embryonic inductive capacity. Cunha et al. (5) summarized the prerequisites for prostatic development to be i) the presence of androgens; ii) the presence of “inductive” stroma and iii) the ability of the epithelium to respond to the inductive influences.


Androgen Receptor Benign Prostatic Hyperplasia Prostatic Carcinoma Prostatic Acid Phosphatase Prostatic Epithelium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • M. A. Blankenstein
    • 1
  • J. C. Romijn
    • 1
  • G. J. van Steenbrugge
    • 1
  • F. H. Schröder
    • 1
  1. 1.Erasmus UniversityRotterdamThe Netherlands

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