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Mapping the X Chromosome

  • Henry F. Epstein
  • Stewart Wolf
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 154)

Abstract

DR. UTA FRANCKE: Before moving on to the mapping of the X chromosome, I would like to review briefly with you the background of and progress in human gene mapping. Figure 35 shows the information on human genetic traits that has been accumulated and compiled by Dr. Victor McKusick in his catalogs. The curve depicting the chromosomal assignments of autosomal traits shows a steep rise in the early 1970s due to the advent of somatic cell genetic techniques, and then flattens a little bit because most genes that can easily be mapped in somatic cell hybrids had been mapped. More recently, the slope increased again due to new technology providing new genetic markers such as DNA segments and antigens defined by monoclonal antibodies. There are now almost 300 loci mapped to specific autosomes, and slightly more than 100 on the X. This information has been reviewed and updated periodically at six international workshops on human gene mapping (79–84).

Keywords

Muscular Dystrophy Duchenne Muscular Dystrophy Hybrid Cell Duchenne Muscular Dystrophy G6PD Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Henry F. Epstein
    • 1
  • Stewart Wolf
    • 2
    • 3
  1. 1.The Jerry Lewis Neuromuscular Disease Research CenterBaylor College of MedicineHoustonUSA
  2. 2.Totts Gap Medical Research LaboratoriesBangorUSA
  3. 3.Temple UniversityPhiladelphiaUSA

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