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DNA Fragmentation: Its Predictivity as a Short Term Test

  • Silvio Parodi
  • Maurizio Taningher
  • Leonardo Santi
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 52)

Abstract

In order to assess the carcinogenic risk it is important not only to know qualitatively if a chemical is a carcinogen, but also to have an idea of its carcinogenic potency. Unfortunately, the epidemiological data almost never allow for a correlation between tumour frequency and dose of a carcinogen. Perhaps the only exception is the carcinogenic effect of ionizing radiations. Because of this general deficiency in the epidemiological data, it is impossible to know if carcinogenic potencies in humans and carcinogenic potencies in small rodents are quantitatively correlated. A quantitative correspondence of scales could exist, even if obviously the latency time of tumours is much longer in humans than in small rodents. Qualitatively, all the compounds found to be carcinogenic in humans were also found to be carcinogenic in small rodents, except for the arsenic derivatives37. On this basis, and on the generic biological basis that carcinogenicity in small rodents is the closest thing to carcinogenicity in humans, carcinogenicity data in small rodents are considered the most relevant for human risk assessment, especially when epidemiological data are not available. For these reasons, the results obtained in the short term tests are always compared with carcinogenicity in small rodents.

Keywords

Aromatic Amine Carcinogenic Risk Small Rodent Short Term Test Hydrazine Derivative 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Silvio Parodi
    • 1
  • Maurizio Taningher
    • 1
  • Leonardo Santi
    • 1
  1. 1.Istituto Scientifico per lo Studio e la Cura dei Tumori and Department of OncologyUniversity of GenoaGenoaItaly

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