Problems Associated with the Use of Chemical Class Controls in Absence of Information on the Underlying Mechanism
It is simply not possible to test all chemicals in adequately performed whole animal carcinogenicity tests. Short-term tests are, therefore, frequently used as a substitute. None of these short-term tests give results which correspond in all cases to the results obtained in whole animal carcinogenicity tests. Certain short-term tests have a notoriously poor predictibility for whole animal carcinogenicity for certain classes of chemicals. Therefore, if a chemical, whose carcinogenicity is unknown, is tested in a short-term test, frequently related compounds of known carcinogenicity are also tested simultaneously as chemical class controls.
KeywordsRelated Compound Positional Isomer Chemical Class Poor Predictibility Epoxide Hydrolase
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