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The Cytoskeleton: An Intermediate in the Expression of the Transformed Phenotype in Malignant Cells

  • B. R. Brinkley
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 52)

Abstract

Transformation of cells in vitro by viral or chemical agents is accompanied by a variety of physiological, morphological, and growth-related changes, including altered lectin-binding characteristics and changes in surface proteins (Burger 1973; Pollack and Burger, 1969). In many forms of neoplasia, striking changes occur in cell morphology, including the transition from flattened anisotropic forms that grow as monolayers to rounded pleomorphic forms that pile up as multilayered foci in culture (Temin and Rubin, 1958; Stoker and Abel, 1962). Changes in growth properties include loss of density-dependent control of growth (Todaro et al., 1964), loss of contact-inhibited mobility (Gail and Boone, 1971), and acquisition of anchorage-independent growth (Stoker and MacPherson, 1961; Freedman and Shin, 1974; Benedict et al., 1975; Evans and DiPaolo, 1975; Risser and Pollack 1974). Transformed cells grow well in media containing reduced serum content and are often characterized by reduced cyclic AMP levels (Smith et. al., 1971; Holly and Kiernan, 1968; Anderson et al., 1973; Sneppard, 1972; Mohanhan et al., 1973). Although it is known that various properties in this list are dissociable and are not linked as a group to malignant transformation, taken collectively these findings attest to the molecular complexity of cell transformation. Since most carcinogenic agents are also thought to be mutagens which interact with nuclear DNA producing point mutations and chromosome rearrangements how are these mutations manifested in the broad spectrum of phenotypic changes which accompany transformation?

Keywords

Intermediate Filament Stress Fiber Cell Transformation Actin Stress Fiber Rous Sarcoma Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • B. R. Brinkley
    • 1
  1. 1.Department of Cell BiologyBaylor College of MedicineHoustonUSA

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