N-Substituted Aromatic Compounds

  • Charles M. King
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 52)


Aromatic compounds that have nitrogen atoms attached to their ring carbons have a potential for eliciting a variety of adverse cytotoxic, mutagenic and carcinogenic responses. The actual biological effects produced by these agents are dependent on their structure, the ability of the host organism to metabolize the compound and the response of the organism to the metabolites that are generated. Although this group of compounds is most often referred to as aromatic amines, the term N-substituted aromatic compounds is more appropriate since it is sufficiently broad to include both nitrocompounds that may be converted metabolically to aromatic amines, as well as metabolites of amines, e.g. hydroxamates, amides and nitroso derivatives, that have quite different chemical properties. This report is intended to provide insight into the carcinogenic potential of these compounds and the mechanisms by which they are believed to effect this activity.


Polycyclic Aromatic Hydrocarbon Mammary Gland Aromatic Amine Bladder Tumor Acyl Transferase 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Charles M. King
    • 1
  1. 1.Department of Chemical CarcinogenesisMichigan Cancer FoundationDetroitUSA

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