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Benign and Malignant Tumor Induction in Mouse Skin

  • Fredric J. Burns
  • Roy E. Albert
  • Bernard Altshuler
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 52)

Abstract

Carcinogenesis has often been assumed to be a multistage disease where a single cell progresses from normal to cancer in discrete sequential stages1,2,3. There is statistical support for the existence of such stages in the shape of functions that describe the dependence of cancer yield on dose and time. Biological evidence in favor of the multistage theory is derived from chromosomally marked clones seen in exacerbations of myeloid leukemia and in the progressive acquisition of automony seen in certain types of tumors, especially, hormone dependent tumors4,5.

Keywords

Clonal Expansion Mouse Skin Clonal Growth Weekly Dose Tumor Induction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Fredric J. Burns
    • 1
  • Roy E. Albert
    • 1
  • Bernard Altshuler
    • 1
  1. 1.NYU Institute of Environmental MedicineNew YorkUSA

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