Benign and Malignant Tumor Induction in Mouse Skin

  • Fredric J. Burns
  • Roy E. Albert
  • Bernard Altshuler
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 52)


Carcinogenesis has often been assumed to be a multistage disease where a single cell progresses from normal to cancer in discrete sequential stages1,2,3. There is statistical support for the existence of such stages in the shape of functions that describe the dependence of cancer yield on dose and time. Biological evidence in favor of the multistage theory is derived from chromosomally marked clones seen in exacerbations of myeloid leukemia and in the progressive acquisition of automony seen in certain types of tumors, especially, hormone dependent tumors4,5.


Clonal Expansion Mouse Skin Clonal Growth Weekly Dose Tumor Induction 
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  1. 1.
    L. Foulds, Neoplastic Development-2. Academic Press, N.Y., (1975).Google Scholar
  2. 2.
    P. Armitage and R. Doll, The Age Distribution of Cancer and a Multistage Theory of Carcinogenesis. Brit. J. Cancer 8: 1–12, (1954).Google Scholar
  3. 3.
    R. Peto and P.N. Lee, Weibull Distribution for Continuous Carcinogenesis Experiments. Biometrics 29: 457–470, (1973).PubMedCrossRefGoogle Scholar
  4. 4.
    J. German, Chromosomes and Cancer. John Wiley, New York, (1974).Google Scholar
  5. 5.
    J. Furth, Conditioned and Autonomous Neoplasms: Review, Cancer Res. 13: 477–492, (1953).PubMedGoogle Scholar
  6. 6.
    F.J. Burns, M. Vanderlaan, E. Snyder and R. Albert, Induction and Progression Kinetics of Mouse Skin Papillomas. In: Carcinogenesis, Vol. 2 Mechanisms of Tumor Promotion and Co-Carcinogenesis. (T.J. Slaga, R.K. Boutwell and A. Sivak, Eds.), Raven Press, New York, N.Y., pp. 91–96, (1978).Google Scholar
  7. 7.
    I. Berenblum, Carcinogenesis as a Biological Problem, Frontiers of Biology, Vol. 34. North Holland Publishing Co., Amsterdam, Oxford, (1974).Google Scholar
  8. 8.
    A. Whittemore and J. Keller, Quantitative Theories of Carcinogenesis. S.I.A.M. Rev. 20: 1–30, (1978).Google Scholar
  9. 9.
    P.M. Iannaccone, R.L. Gardner and H. Harris, The Cellular Origin of Chemically-induced Tumors. J. Cell Sci. 29: 249–269, (1978).PubMedGoogle Scholar
  10. 10.
    F.J. Burns and R.E. Albert, The Additivity of Multiple Doses of a Liver Carcinogen in Rats. Environ. International 1: 391–393, (1978).Google Scholar
  11. 11.
    H. Druckrey, Quantitative Aspects of Chemical Carcinogenesis. In: Potential Carcinogenic Hazards from Drugs, Evaluation of Risks, VICC Monograph Series Vol. 7, (R. Truhart, Ed.), Springer-Vergal, N.Y., pp. 60–78, (1967).Google Scholar
  12. 12.
    R.E. Albert and B. Altshuler, Considerations Relating to the Formulation of Limits for Unavoidable Population Exposures to Environmental Carcinogens. In: Radionuclide Carcinogenesis, (C.L. Sanders, R.H. Busch, J.E. Ballou and D.D. Mahlum, Eds.), AEC Symposium Series, CONF-720505, NTIS, Springfield, Virginia, June, 1973.Google Scholar
  13. 13.
    R. Peto, F.J.C. Roe, R.N. Lee, L. Levy and J. Clack, Cancer and Ageing in Mice and Men. Brit. J. Cancer 32: 411–416, (1975).PubMedCrossRefGoogle Scholar
  14. 14.
    T.J. Slaga, G.T. Bowden, J.D. Scribner and R.K. Boutwell, Dose-Response Studies on the Ability of 7,12-Dimethylbenz(a) anthracene and Benz(a)anthracene to Initiate Skin Tumors. JNCI 53 (5): 1337–1340, (1974).Google Scholar
  15. 15.
    P. Brookes and P.D. Lawley, Evidence for the Binding of Polynuclear Aromatic Hydrocarbons to the Nucleic Acids of Mouse Skin: Relation between Carcinogenic Power of Hydrocarbons and Their Binding to DNA. Nature (Lond.) 202: 781–784, (1964).CrossRefGoogle Scholar
  16. 16.
    M. Duncan, P. Brookes and A. Dipple, A Metabolism and Binding to Cellular Macromolecules of a Series of Hydrocarbons by Mouse Embryo Cells in Culture. Int. J. Cancer 4: 818–819, (1969).CrossRefGoogle Scholar
  17. 17.
    H.V. Gelboin, A Microsomal-dependent Binding of Benzo(a)pyrene to DNA. Cancer Res. 29: 1272–1276, (1969).PubMedGoogle Scholar
  18. 18.
    P.L. Grover, A. Hewer, K. Pal and P. Sims. The Involvement of a Diol Epoxide in the Metabolic Activation of Benzo(a)pyrene in Human Bronchial Mucosa and in Mouse Skin. Int. J. Cancer 18: 1–6, (1976).PubMedCrossRefGoogle Scholar
  19. 19.
    I.B. Weinstein, A.M. Jeffrey, K.W. Jennette, S.H. Blobstein, R.G. Harvey, C. Harris, H. Autrup, H. Kasai and K. Nakanishi, Benzo(a)pyrene Diol Epoxides as Intermediates in Nucleic Acid Binding in vitro and in vivo. Science 193: 592–595, (1976).PubMedCrossRefGoogle Scholar
  20. 20.
    T. Meehan, K. Strabu and M. Calvin, Benzo(a)pyrene Diol Epoxide Covalently Binds to Deoxyguanosine and Deoxyadenosine in DNA. Nature (Lond.) 269: 725–727, (1977).CrossRefGoogle Scholar
  21. 21.
    K.S. Crump, D.G. Hoel, C.H. Langley and R. Peto. Fundamental Carcinogenic Processes and Their Implications for Low Dose Risk Assessment. Cancer Res. 36: 2973, (1976).PubMedGoogle Scholar
  22. 22.
    T.J. Slaga, S.M. Fischer, K. Nelson and G.L. Gleason, Studies on the Mechanism of Skin Tumor Promotion: Evidence for Several Stages in Promotion. PNAS 77: 3659–3663, (1980).Google Scholar
  23. 23.
    F. Burns, M. Vanderlaan, A. Sivak and R. Albert, The Regression Kinetics of Mouse Skin Papillomas. Cancer Res. 36: 1422–1427, (1976).PubMedGoogle Scholar
  24. 24.
    E.J. Andrews, The Morphological, Biological and Antigenic Characteristics of Transplantable Papillomas and Keratinous Cysts Induced by Methylcholanthrene. Cancer Res. 34: 2842–2851, (1974).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Fredric J. Burns
    • 1
  • Roy E. Albert
    • 1
  • Bernard Altshuler
    • 1
  1. 1.NYU Institute of Environmental MedicineNew YorkUSA

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