Alterations of Liver Architecture in Mice Treated with Anabolic Androgens and Diethylnitrosamine
It has been recognised for decades that there is a relationship between endogenous steroid sex hormones and cancers of organs and tissues which are target organs of these steroids. The most extensively studied cancers are those of the breast, uterus and prostate gland. However, it is still a matter of debate as to whether or not the steroids themselves (or activated metabolites) are implicated in the start of the process(es) which cause the tissues to develop malignant tumours. That is, are endogenous steroid hormones initiators of carcinogenesis? Many other factors have been implicated in the development and progress of hormone-related cancers in man; family history, parity, ethnic origins, oncongenic viruses, etc. Thus it seems that many complex and interacting processes are involved in the incidence and development of many human cancers (see Review by Taylor, 1981a).
KeywordsLiver Tumour Anabolic Steroid Anabolic Agent Biliary Lipid Hyperplastic Nodule
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