Advertisement

Alterations of Liver Architecture in Mice Treated with Anabolic Androgens and Diethylnitrosamine

  • W. Taylor
  • S. Snowball
  • C. M. Dickson
  • Milena Lesna
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 52)

Abstract

It has been recognised for decades that there is a relationship between endogenous steroid sex hormones and cancers of organs and tissues which are target organs of these steroids. The most extensively studied cancers are those of the breast, uterus and prostate gland. However, it is still a matter of debate as to whether or not the steroids themselves (or activated metabolites) are implicated in the start of the process(es) which cause the tissues to develop malignant tumours. That is, are endogenous steroid hormones initiators of carcinogenesis? Many other factors have been implicated in the development and progress of hormone-related cancers in man; family history, parity, ethnic origins, oncongenic viruses, etc. Thus it seems that many complex and interacting processes are involved in the incidence and development of many human cancers (see Review by Taylor, 1981a).

Keywords

Liver Tumour Anabolic Steroid Anabolic Agent Biliary Lipid Hyperplastic Nodule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anderson, A., James, O.F.W., MacDonald, H.S., Snowball, S., and Taylor, W., 1980, The effects of ethynyl oestradiol on biliary lipid composition in young men, Eur. J. Clin. Invest., 10: 77–80.PubMedCrossRefGoogle Scholar
  2. Dickson, C.M., Lesna, M., and Taylor, W., 1979, The effects of anabolic androgens on gall-bladder bile acids and cholesterol in mice, J. Steroid Biochem., 11: 1567–1571.PubMedCrossRefGoogle Scholar
  3. Evans, D.J., 1978, Liver tumours elicited by specific factors: synthetic androgens and anabolic steroids, In: “Primary Liver Tumours”, H. Remmer, H.M. Bolt, P. Bannasch, and H. Popper, ed., MTP Press, Lancaster, England, pp. 213–216.Google Scholar
  4. Farber, E., 1980, The sequential analysis of liver cancer induction, Biochim. Biophys. Acta, 605: 119–166.Google Scholar
  5. Firminger, H.I., and Reuber, M.D., 1961, Influence of adrenocortical, androgenic and anabolic hormones on the development of carcinoma and cirrhosis of the liver in A X C rats fed N-2-fluorenyldiacetamide, J. Natl. Cancer Inst., 27: 559–570.PubMedGoogle Scholar
  6. Ishak, K.G., 1979, Hepatic neoplasms associated with contraceptive and anabolic steroids, In: “Carcinogenic Hormones”, C.H. Ligeman, ed., Springer-Verlag, Berlin, pp. 73–128.Google Scholar
  7. Paradinas, F.J., Bull, T.B., Westaby, D., and Murray-Liôn, I.M., 1977, Hyperplasia and prolapse of hepatocytes into hepatic veins during long-term methyltestosterone therapy: possible relationships of these changes to the development of peliosis hepatis and liver tumours, Histopathology, 1: 225–238.PubMedCrossRefGoogle Scholar
  8. Reuber, M.D., 1974, The importance of the testes in the induction of hyperplastic nodules, carcinomas and cirrhosis of the liver in A X C strain male rats ingesting 0.025 per cent N-2-fluorenyldiacetamide, J. Natl. Cancer Inst., 53: 883–891.PubMedGoogle Scholar
  9. Reuber, M.D., 1976, Effect of age and testosterone on the induction of hyperplastic nodules, carcinomas and cirrhosis of the liver in rats ingesting N-2-fluorenyldiacetamide, Eur. J. Cancer, 12: 137–115.PubMedCrossRefGoogle Scholar
  10. Sherlock, S., 1978, Hepatic tumours and sex hormones, In: “Primary Liver Tumours”, H. Remmer, H.M. Bolt, P. Bannasch, and H. Popper, ed., MTP Press, Lancaster, England, pp. 201–212.Google Scholar
  11. Taylor, W., 1981a, Toxicology and carcinogenicity of anabolic agents in human subjects, In: “Anabolic Agents in Beef and Veal Production”, Proc. Workshop, Brussels, under auspices of the European Communities Directorate General for Agriculture, B. Hoffman and J.F. Roche., ed., Agricultural University, Dublin, Ireland, pp. 113–138.Google Scholar
  12. Taylor, W., 1981b, The relationship between steroids and cancer in man, and its relevance to the use of steroidal anabolic agents in farm animals, In: “Steroids in Animal Production”, H. Jasiorowski, ed., Warsaw Agricultural University, Warsaw, Poland, pp. 235–217.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • W. Taylor
    • 1
    • 2
    • 3
  • S. Snowball
    • 1
  • C. M. Dickson
    • 2
  • Milena Lesna
    • 3
  1. 1.Department of Physiological SciencesThe Medical School, The UniversityNewcastle upon TyneEngland
  2. 2.The Animal UnitThe Medical School, The UniversityNewcastle upon TyneEngland
  3. 3.Department of PathologyRoyal Victoria HospitalBournemouthEngland

Personalised recommendations