Synthetic Forms of Selenium and Their Chemotherapeutic Uses

  • Raymond J. Shamberger
Part of the Biochemistry of the Elements book series (BOTE, volume 2)


Because of the close resemblance of selenium to the biologically important element sulfur, a strong rationale exists for the incorporation of selenium into potential medicinal agents. In many cases selenium isoesters of sulfur-containing antibacterial agents are as effective as their analogous sulfur compounds or sometimes even more effective. Inorganic selenium compounds, when tested at the same selenium concentration as the active organic selenium compounds, have comparatively negligible antibacterial activity (Green and Bielschowsky, 1942). Many of the selenium compounds studied as potential bactericides during World War II were modeled after the sulfonamide drugs. Although no direct sulfur-selenium interchanges to give the analogous selenoamides have been accomplished, a close derivative may be found in bis(p-aminophenyl) selenide (I) and bis(p-aminophenyl) diselenide (II). (Table 9-1 lists structures I-XV.) The bis(p-aminophenyl) diselenide is very effective against Brucella paramelitensis and Staphylococcus aureus (Green and Bielschowsky, 1942). The diselenide is a thousandfold more effective as an antibacterial agent than bis(p-aminophenyl) disulfide. The corresponding acid is also active against B. paramelitensis and S. aureus (Green and Bielschowsky, 1942). The selenium of sulfathiazole (HI) has shown some activity in vitro against Pneumococcus (Jensen and Schmith, 1941). The methyl alkyl selenoxide hydronitrate (IV) derivatives have been patented as germicides for inclusion in detergent formulations (Priestly, 1972).


Selenium Compound Ehrlich Ascites Tumor Cell Synthetic Form Organoselenium Compound Diphenyl Diselenide 


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Raymond J. Shamberger
    • 1
  1. 1.The Cleveland Clinic FoundationClevelandUSA

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