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Selenium in Health and Disease

  • Chapter
Biochemistry of Selenium

Part of the book series: Biochemistry of the Elements ((BOTE,volume 2))

Abstract

One of the more exciting effects of selenium on health is selenium’s anticarcinogenic effect against experimentally induced cancer in several animal systems.

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References

  • Abdullaev, G. B., Gasanov, G. G., Ragimov, R. N., Teplyakova, G. V., Mekhtiev, M. A., and Dzhafarov, A. I., 1973. Selenium and tumor growth under experimental conditions, Dokl. Akad. Nauk Azerb. SSR, 29:18–24.

    CAS  Google Scholar 

  • Abdullaev, G. B., Gasanov, G. G., Kulieva, E. M., Dzhafarov, A. I., and Perelygin, B. B., 1981. Effect of selenium on the electroretinogram of isolated retina of cold-blooded animals, Dokl. Akad. Nauk Az. SSR 37:29–34.

    CAS  Google Scholar 

  • Adams, G., Martin, S., and Milner, J., 1980. Effects of selenium on the Salmonella/micro-some mutagen test system, Fed. Proc. Fed. Am. Soc. Exp. Biol. 39:790.

    Google Scholar 

  • Aherne, W., Piali, E., and Marks, V., 1978. Radioimmunoassay of methotrexate: Use of 75Se-labelled methotrexate, Ann. Clin. Biochem. 15:331–334.

    PubMed  CAS  Google Scholar 

  • Ahmed, Z. U., and Walker, G. W. R., 1975. The effects of urethane, sodium monohydrogen arsenate and selenocystine on crossing-over in Drosophilia melanogaster, Can. J. Genet. Cytol. 17:55–66.

    CAS  Google Scholar 

  • Aleksondrovicz, J., 1977. Effects of food enrichment with various doses of sodium selenite on some immune response in laboratory animals, Rocz. Nauk. Zootech. 4:113–126.

    Google Scholar 

  • Anderson, T. W., 1973. Nutritional muscular dystrophy and human myocardial infarction, Lancet 2:298–302.

    Article  PubMed  CAS  Google Scholar 

  • Balanski, R. M. and Hadsiolov, D. H., 1979. Influence of sodium selenite on the hepatocarcinogenic action of diethylnitrosamine in rats, Comptes Rendus de l’Academie Bulgare Des Sciences, 32:697–698.

    CAS  Google Scholar 

  • Banner, W. P., Tan, Q. H., and Zadeck, S., 1981. Studies of the mechanism by which selenium inhibits tumor formation, Proc. Am. Assoc. Cancer Res. 22:115.

    Google Scholar 

  • Bawden, J. W., and Hammarstrom, L. E., 1977. Autoradiography of selenium-75 in developing rat teeth and bone, Caries Res. 11:195–203.

    Article  PubMed  CAS  Google Scholar 

  • Berenshtein, T. F., 1972. Effect of selenium and vitamin E on antibody formation in rabbits, Zdrawookhr Boloruss 18:34–41.

    CAS  Google Scholar 

  • Berenshtein T. F., 1973. Stimulation of a nonspecific immunity in immunized rabbits by sodium selenite, Ser. Biyal Navek 1:87–89.

    Google Scholar 

  • Behrenshtein, T. F., 1975. Change in the immunological response of vaccinated rabbits following the administration of selenium and vitamin A, Selen. Biol. Mater. Nauchen. Konf., 2nd, 1:94–96.

    Google Scholar 

  • Berenshtein, T. F., and Zdravoukhi, 1976. Stimulation of the activity of nonspecific immunity factors by biological bases of molybdenum and selenium, Belowes 3:67–68.

    Google Scholar 

  • Bhuyan, K. C., Bhuyan, D. K., and Podos, S. M., 1981a. Evidence of increased lipid peroxidation in cataracts, IRCS Medical Science, Pathology 9:126–127.

    CAS  Google Scholar 

  • Bhuyan, K. C., Bhuyan, D. K., and Podos, S. M., 1981b. Cataract induced by selenium in rat: II. Increased lipid peroxidation and impairment of enzymatic defense against oxidative damage, IRCS Medical Science, Pharmacology 9:195–196.

    CAS  Google Scholar 

  • Bieri, J. G., Dam, H., Prange, I., and Sondergaard, E., 1961. Effect of dietary selenium dioxide, cystine, ethoxyquin and vitamin E on lipid autoxidation in chick tissues, Acta Physiol. Scand. 52:36–43.

    Article  CAS  Google Scholar 

  • Blau, M., and Bender, M. A., 1962. 75Se-selenomethionine for visualization of the pancreas by isotope scanning, Radiology 78:974–979.

    PubMed  CAS  Google Scholar 

  • Bogden, J. B., Kemp, F. W., Buse, M., Thind, I. S., Louria, D. B., Forgacs, J., Llanos, G., and Terrones, I. M., 1981. Composition of tobaccos from countries with high and low incidences of lung cancer. I. Selenium, Polonium-210, Alternaria, tar and nicotine, J. Nat. Cancer Inst. 66:27–31.

    PubMed  CAS  Google Scholar 

  • Bowen, W. H., 1972. The effect of selenium and vanadium on caries activity in monkeys (Macaca irus), J. Irish Dent. Assoc. 18:83–89.

    Google Scholar 

  • Boyne, R., and Arthur, J. R., 1979. Alterations of neutrophil functions in selenium deficient cattle, J. Comp. Path. 89:151–158.

    Article  PubMed  CAS  Google Scholar 

  • Bradley, C. J., Kledzik, G. S., and Meites, J., 1976. Prolactin and estrogen dependency of rat mammary cancers at early and late stages of development, Cancer Res. 36:319–324.

    PubMed  CAS  Google Scholar 

  • Britton, J. L., Shearer, T. R., and DeSart, D. J., 1980. Cariostasis by moderate doses of selenium in the rat model, Arch. Envir. Health, 35:74–76.

    CAS  Google Scholar 

  • Broghamer, W. L., McConnell, K. P., and Blotcky, A. J., 1976. Relationship between serum selenium levels and patients with carcinoma, Cancer 37:1384–1388.

    Article  PubMed  CAS  Google Scholar 

  • Broghamer, W. L., McConnell, K. P., Grimaldi, M., and Blotcky, A. J., 1978. Serum selenium and reticuloendothelial tumors, Cancer 41:1462–1466.

    Article  PubMed  CAS  Google Scholar 

  • Burch, R. E., Sullivan, J. F., Jetton, M. M., and Hahn, H. K. J., 1979. The effect of aging on trace element content of various rat tissues: 1. Early stages of aging, Age 2:103–107.

    Article  CAS  Google Scholar 

  • Buttner, W., 1963. Action of trace elements on the metabolism of fluoride, J. Dent. Res. 42:453–460.

    Article  Google Scholar 

  • Calautti, P., Moschini, G., Stievano, B. M., Tornio, L., Calzavara, F., and Perona, G., 1980. Serum selenium levels in malignant lymphoproliferative diseases, Scand. J. Haematol. 24:63–66.

    Article  PubMed  CAS  Google Scholar 

  • Capel, I. D., and Williams, D. C., 1979. Selenium and glutathione peroxidase in breast cancer, Obstet. Gynecol. 7:425.

    CAS  Google Scholar 

  • Castillo, R., Landon, C., Eckhardt, K., Morris, V., Levander, O., and Lewiston, N., 1981. Selenium and vitamin E status in cystic fibrosis, J. Pediat. 99:583–585.

    Article  PubMed  CAS  Google Scholar 

  • Chen, X., Yang, G., Chen, J., Chen, X., Wen, Z., and Ge, K., 1980. Studies on the relations of selenium and Keshan disease, Biol. Trace Elem. Res. 2:91–107.

    Article  CAS  Google Scholar 

  • Chio, K. S., Reiss, U., Fletcher, B., and Tappel, A. L., 1969. Peroxidation of subcellular organelles: Formation of lipofuscin like fluorescent pigments, Science 166:1535–1536.

    Article  PubMed  CAS  Google Scholar 

  • Clayton, C. C., and Baumann, C. A., 1949. Diet and azo dye tumors: Effect of diet during a period when the dye is not fed, Cancer Res. 9:575–582.

    PubMed  CAS  Google Scholar 

  • Collipp, P. J., and Chen, S. Y., 1981. Cardiomyopathy and selenium deficiency in a two-year-old girl, New Eng. J. Med. 304:1304–1305.

    Article  PubMed  CAS  Google Scholar 

  • Crisp, F. D., Deaton, T. G., and Bawden, J. W., 1979. In vitro study of selenium-75 distribution in developing rat molar enamel, Caries Res. 13:313–318.

    Article  PubMed  CAS  Google Scholar 

  • Cross, J. D., Raie, R. M., and Smith, H., 1981. Bromine and selenium in human aorta, J. Clin. Path. 34:393–395.

    Article  PubMed  CAS  Google Scholar 

  • Crowley, M. F., Garbien, K. J. T., and Tuttlebee, J. W., 1975. Assessment of a simple competitive protein-binding technique for plasma Cortisol assay, Ann. Clin. Biochem. 12:66–69.

    PubMed  CAS  Google Scholar 

  • Curzon, M. E. J., and Crocker, D. C., 1978. Relationship of trace elements in human tooth enamel to dental caries, Arch. Oral Biol. 23:647–653.

    Article  PubMed  CAS  Google Scholar 

  • Cutler, M. G., and Schneider, R., 1974. Linoleate oxidation products and cardiovascular lesions, Atherosclerosis 20:383–394.

    Article  PubMed  CAS  Google Scholar 

  • Daoud, A. H., and Griffin, A. C., 1980. Effect of retinoic acid, butylated hydroxytoluene, selenium and sorbic acid on azo-dye hepatocarcinogenesis, Cancer Lett. 9:299–304.

    CAS  Google Scholar 

  • Desowitz, R. S., and Barnwell, J. W., 1980. Effect of dimethyl dioctadecyl ammonium bromide on the vaccine-induced immunity of Swiss-Webster mice against malaria (Plasmodium berghei), Infect. Immun. 27:87–89.

    PubMed  CAS  Google Scholar 

  • Dickson, R. C., and Tomlinson, R. H., 1967. Selenium in blood and human tissues, Clin.Chem.Acta 16:311–321.

    Article  CAS  Google Scholar 

  • DiGiulio, W., and Morales, J. O., 1969. The value of the selenomethionine Se75 scan in preoperative localization of parathyroid adenomas, JAMA 209:1873–1880.

    Article  PubMed  CAS  Google Scholar 

  • Dosseto, M., Rohner, C., Pierres, M., and Gordis, C., 1981. Biosynthetic incorporation of {75Se} selenomethionine: A new method for labelling, lymphocyte membrane antigens, J. Immunol. Meth. 41:145–153.

    Article  CAS  Google Scholar 

  • Duncan, D., Nail, D., and Morales, R., 1960. Observations on the fine structure of old age pigment, J. Gerontol. 15:366–372.

    Article  PubMed  CAS  Google Scholar 

  • Dzhioev, F. D., 1978. Effect of selenium, phenobarbital, teturam, and carbon tetrachloride on the carcinogenic effect of diethylnitrosamine and 1,2-dimethylhydrazine, in Kantserog N-Nitrozonsoedin: Deistvie, Obraz., Opred., Mater Simp., 3rd ed., G. O. Loogna (ed.), Tallinn, USSR, pp. 51–53.

    Google Scholar 

  • Evatt, B. L., Spivak, J. L., and Levin, J., 1976. Relationships between thrombopoiesis and erythropoiesis: With studies of the effects of preparations of thrombopoietin and erythropoietin, Blood 48:547–558.

    PubMed  CAS  Google Scholar 

  • Exon, J. H., Koller, L. D., and Elliott, S. C., 1976. Effect of dietary selenium on tumor induction by an oncogenic virus, Clin. Toxicol. 9:273–279.

    Article  PubMed  CAS  Google Scholar 

  • Gillett, A. S., and Wakeley, C. P. G., 1922. Selenium in the treatment of malignant disease, Brit. J. Surg. 9:532–539.

    Article  Google Scholar 

  • Glavind, J., Hartmann, S., Clemmesen, J., Jessen, K. E., and Dam, H., 1952. Studies on the role of lipoperoxides in human pathology, Part 2. The presence of peroxidized lipids in the atherosclerotic aorta, Acta Pathol. Microbiol. Scand. 30:1–6.

    Article  PubMed  CAS  Google Scholar 

  • Godwin, K. O., 1965. Abnormal electrocardiograms in rats fed a low selenium diet Q. J. Exp. Physiol. 50:282–288.

    CAS  Google Scholar 

  • Godwin, K. O., and Fraser, F. J., 1966. Abnormal electrocardiograms, blood pressure changes and some aspects of the histopathology of selenium deficiency in lambs Q. J. Exp. Physiol. 51:94–102.

    CAS  Google Scholar 

  • Greeder, G. A., and Milner, J. A., 1980. Factors influencing the inhibitory effect of selenium on mice inoculated with Ehrlich ascites tumor cells, Science 209:825–827.

    Article  PubMed  CAS  Google Scholar 

  • Griffin, A. C., and Jacobs, M. M., 1977. Effects of selenium on azo dye hepatocarcinogenesis, Cancer Lett. 3:177–181.

    Article  PubMed  CAS  Google Scholar 

  • Guo, J., Li, G., Zhao, W., Tang, F., Zhang, X., and Zhang, C., 1981. Cardiovascular effects of sodium selenite, Chung kuo Yao Li Hsueh Pao 2:93–97.

    PubMed  CAS  Google Scholar 

  • Hadjimarkos, D. M., 1956. Geographic variations of dental caries in Oregon, J. Pediatr. 48:195–201.

    Article  PubMed  CAS  Google Scholar 

  • Hadjimarkos, D. M., 1968. Effect of trace elements on dental caries, in Advances in Oral Biology, Vol. 3, P. H. Staple (ed.), Academic Press, New York, pp. 253–292.

    Google Scholar 

  • Hadjimarkos, D. M., and Bonhorst, C. W., 1958. The trace element selenium and its influence on dental caries susceptibility, J. Pediatr. 52:274–278.

    Article  PubMed  CAS  Google Scholar 

  • Hadjimarkos, D. M., and Bonhurst, C. W., 1959. Selenium content of human teeth, Oral Surg. 12:112–116.

    Article  Google Scholar 

  • Hadjimarkos, D. M., and Bonhorst, C. W., 1961. The selenium content of eggs, milk and water in relation to dental caries in children, J. Pediatr. 59:265–259.

    Article  Google Scholar 

  • Harbach, P. R., and Swenberg, J. A., 1981. Effects of selenium on 1,2-dimethylhydrazine metabolism and DNA alkylation, Carcinogenesis 2:575–580.

    Article  PubMed  CAS  Google Scholar 

  • Harland, W. A., Gilbert, J. D., and Brooks, C. J. W., 1973. Lipids of human atheroma, Part 8. Oxidized derivatives of cholesteryl lineoleate, Biochem. Biophys. Acta 316:378–385.

    Article  PubMed  CAS  Google Scholar 

  • Harman, D., Heidrick, M. L., and Eddy, D. E., 1977. Free radical theory of aging: Effect of free-radical inhibitors on the immune response, J. Am. Ger. Soc. 25:400–407.

    CAS  Google Scholar 

  • Harr, J. R., Bone, J. F., Tinsley, I. J., Weswig, P. H., and Yamamoto, R. S., 1967. Selenium toxicity in rats. II. Histopathology, in Symposium: Selenium in Biomedicine, O. H. Muth (ed.), Avi Publishing Company, Westport, Connecticut, pp. 153–178.

    Google Scholar 

  • Harr, J. R., Exon, J. H., Whanger, P. D., and Weswig, P. H., 1972. Effect of dietary selenium on N-2 fluorenyl-acetamide (FAA)-induced cancer in vitamin E supplemented, selenium depleted rats, Clin. Toxicol. 5:187–194.

    Article  PubMed  CAS  Google Scholar 

  • Harr, J. R., Exon, J. H., Weswig, P. H., and Whanger, P. D., 1973. Relationship of dietary selenium concentration; chemical cancer induction; and tissue concentration of selenium in rats, Clin. Toxicol. 8:487–495.

    Article  Google Scholar 

  • Hendley, D. D., Mildvan, A. S., Reporter, M. C., and Strehler, B. L., 1963. The properties of human cardiac age pigment. II. Chemical and enzymatic properties, J. Gerontol. 18:250–259.

    Article  PubMed  CAS  Google Scholar 

  • Heinrich, H. C., Gabbe, E. E., Bartels, H., Oppitz, K. H., Bender-Gotze, C., and Pfau, A. A., 1977. Bioavailability of food iron-(59Fe), vitamin Bi2-(60Co) and protein bound selenomethionine-{75Se} in pancreatic exocrine insufficiency due to cystic fibrosis, Klin. Wschr. 55:595–601.

    Article  PubMed  CAS  Google Scholar 

  • Hilliyard, L. A., and Abraham, S., 1979. Effect of dietary polyunsaturated fatty acids on growth of mammary adenocarcinomas in mice and rats, Cancer Res. 39:4430–4437.

    Google Scholar 

  • Hilse, H., Oehme, P., Krause, W., and Hecht, K., 1979. Effect of sodium selenite on experimental hypertension in rat, Bulg. Acad. Sci. 5:47–50.

    CAS  Google Scholar 

  • Hsieh, H. S., and Ganther, H. E., 1975. Acid-volatile selenium formation catalyzed by glutathione reductase, Biochemistry 14:1632–1636.

    Article  PubMed  CAS  Google Scholar 

  • Ip, C., 1981a. Factors influencing the anticarcinogenic efficacy of selenium in dimethylbenzanthracene-induced mammary tumorigenesis in rats, Cancer Res. 41:2683–2686.

    PubMed  CAS  Google Scholar 

  • Ip, C., 1981b. Prophylaxis of mammary neoplasia by selenium supplementation in the initiation and promotion phases of chemical carcinogenesis, Cancer Res. 41:4386–4390.

    PubMed  CAS  Google Scholar 

  • Ip, C., 1981c. Modification of mammary carcinogenesis and tissue peroxidation by selenium deficiency and dietary fat, Nutr. Cancer, 2:136–142.

    Article  PubMed  CAS  Google Scholar 

  • Ip, C., and Ip, M. M., 1981. Chemoprevention of mammary tumorigenesis by a combine regimen of selenium and vitamin A, Carcinogenesis 2:915–918.

    Article  PubMed  CAS  Google Scholar 

  • Ip, C., and Sinha, D. K., 1981. Enhancement of mammary tumorigenesis by dietary selenium deficiency in rats with a high polyunsaturated diet, Cancer Res. 41:31–34.

    PubMed  CAS  Google Scholar 

  • Ip, C., Yip, P., and Bernardis, L. L., 1980. Role of prolactin in the promotion of dimethylbenzanthracene-induced mammary tumors by dietary fat, Cancer Res. 40:374–378.

    PubMed  CAS  Google Scholar 

  • Ip, C., Ip, M. M., and Kim, U., 1981. Dietary selenium intake and growth of the MT-W9B transplantable rat mammary tumor, Cancer Lett. 14:101–107.

    Article  PubMed  CAS  Google Scholar 

  • Jaakkola, K., Kurkela P., Arstila, A. U., and Larni, H. M., 1981. Selenium and degenerative heart disease. Part II. Clinical studies. Selenium and vitamin E in the treatment of cardiac pain and diseases, in Mineral Elements 80. A Nordic Symposium on Soil-Plant-Animal-Man Interrelationships and Implications to Human Health, Helsinki, Finland, December 9–11, 1980, pp. 225–233.

    Google Scholar 

  • Jacobs, M. M., Matney, T. S., and Griffin, A. C., 1977. Inhibitory effects of selenium on the mutagenicity of 2-acetylaminofluorene (AAF) and AAF metabolites Cancer Lett. 2:319–322.

    Article  PubMed  CAS  Google Scholar 

  • Jacobs, M. M., Jansson, B., and Griffin, A. C., 1977. Inhibitory effects of selenium on 1,2-dimethylhydrazine and methylazoxymethanol acetate induction of colon tumors, Cancer Lett. 2:133–138.

    Article  PubMed  CAS  Google Scholar 

  • Jacobs, M. M., Shubik, P., and Feldman, R., 1980. Influence of selenium on vascularization in the hamster cheek pouch, Cancer Lett. 9:353–357.

    Article  PubMed  CAS  Google Scholar 

  • Jacobs, M. M., Forst, C. F., and Beams, F. A., 1981. Biochemical and clinical effects of selenium on dimethylhydrazine-induced colon cancer in rats, Cancer Res. 41:4458–4465.

    PubMed  CAS  Google Scholar 

  • Jansson, B., and Jacobs, M. M., 1976. Selenium-a possible inhibitor of colon and rectum cancer, in Proceedings of the Symposium on Selenium-Tellurium in the Environment, Industrial Health Foundation, Pittsburgh, pp. 326–340.

    Google Scholar 

  • Jensen, E. G., Clausen, J., Melchior, J. C., and Konat, G., 1977. Clinical, social and biochemical studies on Batten’s syndrome, Eur. Neurol. 15:203–211.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, J. R., and Shearer, T. R., 1979. Selenium uptake into teeth determined by fluorimetry, J. Dent. Res. 58:1836–1839.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, R. A., Baker, S. S., Fallon, J. T., Maynard, E. P., Ruskin, J. N., Wen, Z., Ge, K., and Cohen, H. J., 1981. An occidental case of cardiomyopathy and selenium deficiency, New Eng. J. Med. 304:1210–1212.

    Article  PubMed  CAS  Google Scholar 

  • Kada, T., Tutikawa, K., and Sadaie, Y., 1972. In vitro and host mediated “rec assay” procedures for screening chemical mutagens; and phloxine, a mutagenic red dye detected, Mutation Res. 16:165–174.

    Article  PubMed  CAS  Google Scholar 

  • Kanematsu, N., Hara, M., and Kada, T., 1980. Rec assay and mutagenicity studies on metal compounds, Mutation Res. 77:109–116.

    Article  PubMed  CAS  Google Scholar 

  • Kay, M. M. B., 1976. Aging and the decline of immune responsiveness, in Basic and Clinical Immunology, H. H. Fudenberg (ed.), Lange Medical Publications, Los Altos, California, pp. 267–278.

    Google Scholar 

  • King, W. W., Michel, L. Wood, W. C., Malt, R. A., Baker, S. S., and Cohen, H. J., 1981. Reversal of selenium deficiency with oral selenium, New Eng. J. Med. 304:1304–1305.

    Article  Google Scholar 

  • Koller, L. D., Issacson-Kerkvliet, N., Exon, J. H., Brauner, J. A., and Patton, N. M., 1979. Synergism of methylmercury and selenium producing enhanced antibody formation in mice, Arch. Environ. Hlth. 34:248–251.

    CAS  Google Scholar 

  • Kollmorgan, R. E., Alexander S. S., and King, M., 1979. Inhibition of lymphocyte function in rats fed high-fat diets, Cancer Res. 39:3458–3462.

    Google Scholar 

  • Koobs, D. H., Schultz, R. L., and Jutzy, R. V., 1978. The origin of lipofuscin and possible consequences to the myocardium, Arch. Pathol. Lab. Med. 102:66–68.

    PubMed  CAS  Google Scholar 

  • Kuhnlein, H. V., Levander, O. A., King, J. C., Sutherland, B., and Riskie, L., 1981. Dietary selenium and fecal mutagenicity in young men, Fed. Proc. Fed. Am. Soc. Exp. Biol. 40:903.

    Google Scholar 

  • Kurkela, P., and Jaakkola, K., 1980. Selenium and degenerative heart disease. Part I. Endemic studies. Endemic studies of the etiologic relationship between selenium and myocardial infarction, in Mineral Elements 80, A Nordic Symposium on Soil-Plant-Animal-Man Interrelationships and Implications to Human Health, Helsinki, Finland, December 9–11, 1980, pp. 279–292.

    Google Scholar 

  • Kurtzke, J. F., 1980. Geographic distribution of multiple sclerosis: An update with special reference to Europe and the Mediterranean region, Acta Neurol. Scand. 62:65–80.

    Article  PubMed  CAS  Google Scholar 

  • Lawson, T., and Birt, D., 1981. BOP induced damage of pancreas DNA and its repair in hamsters pretreated with selenium, Proc. Am. Assoc. Cancer Res. 22:93.

    Google Scholar 

  • Levitt Research Laboratories, 1979. Antiinflammatory compositions containing selenium compounds, U.S. Appl. No. 821, 156, Chem. Abst. 91:96638s.

    Google Scholar 

  • Litvitskii, P. F., Kogan, A. K., Kudrin, A. N., and Lukyanova, L. O., 1981. Pathogenic role of lipid peroxidation activation and the protective effect of sodium selenite during ischemia and myocardial reperfusion, Byull. Eksp. Biol. Med. 91:271–274.

    Article  CAS  Google Scholar 

  • Lloyd-Still, J. D., and Ganther, H. E., 1980. Selenium and glutathione peroxidase levels in cystic fibrosis, Pediatrics 65:1010–1012.

    PubMed  CAS  Google Scholar 

  • Lofroth, G. and Ames, B. N., 1978. Mutagenicity of inorganic compounds in Salmonella typhimurium: Arsenic, chromium, and selenium, Mutation Res. 53:65–66.

    Article  Google Scholar 

  • Lo, L. W., Koropatnick, J., and Stich, H. F., 1978. The mutagenicity and cytotoxicity of selenite, “activated” selenite and selenate for normal and DNA repair-deficient human fibroblasts, Mutation Res. 49:305–312.

    Article  PubMed  CAS  Google Scholar 

  • Lotliker, P. D., Enomoto, M., Miller, J. A., and Miller, E. C., 1967. Species variations in the N- and ring-hydroxylation of 2-acetylaminofluorene and effects of 3-methylchol-anthrene pretreatment, Proc. Soc. Exp. Biol. Med. 125:341–346.

    Google Scholar 

  • Lotliker, P. D., Hong, Y. S., and Baldy, W. L., 1978. Effects of 3-methylcholanthrene pretreatment on 2-acetylaminofluorene N- and ring-hydroxylation by rat and hamster liver microsomes, Toxicol. Lett. 2:135–139.

    Article  Google Scholar 

  • Ludwig, T. G., and Bibby, B. G., 1969. Geographic variations in the prevalence of dental caries in the United States of America, Caries Res. 3:32–43.

    Article  PubMed  CAS  Google Scholar 

  • Marsh, J. A., Dietert, R. R., and Combs, G. F., 1981. Influence of dietary selenium and vitamin E on the humoral immune response of the chick, Proc. Soc. Exp. Biol. Med. 166:228–236.

    PubMed  CAS  Google Scholar 

  • Marshall, M. V., Arnott, M. S., Jacobs, M. M., and Griffin, A. C., 1979. Selenium effects on the carcinogenicity and metabolism of 2-acetylaminofluorene, Cancer Lett. 7:331–338.

    Article  PubMed  CAS  Google Scholar 

  • Martin, J. L., and Spallholz, J. E., 1977. Selenium in the immune response, in Proceedings of the Symposium on Selenium-Tellurium in the Environment, Industrial Health Foundation, Pittsburgh, pp. 204–225.

    Google Scholar 

  • Martin, S. E., Adams, G. H., Schillaci, M., and Milner, J. A., 1981. Antimutagenic effects of selenium on acridine orange and 7,12-dimethylbenzanthracene in the Ames Salmonella/microsomal system, Mutat. Res. 82:41–46.

    Article  PubMed  CAS  Google Scholar 

  • Matsumoto, M., Wakasugi, H., and Ibayashi, H., 1981. Serum vitamin E, lipid peroxide and glutathione peroxidase in patients with chronic pancreatitis, Clin. Chim. Acta 110:121–125.

    CAS  Google Scholar 

  • Matthes, G., Hackensellner, H. A., Jentzsch, K. D., and Oehme, P., 1981. Further studies on the cryoprotection supporting efficiency of selenium compounds, Cryo-Lett. 2:241–245.

    CAS  Google Scholar 

  • Matthes, G., Hackensellner, H. A., Richter, R., Oehme, P., and Jentzsch, K. D., 1980. Contractility and membrane of cryopreserved auricle fragments from rat hearts after pretreatment with selenium, Acta Physiol. Pharmacol. Bulgarica 6:60–64.

    CAS  Google Scholar 

  • Mautner, H. G., and Jaffe, J. J., 1958. The activity of 6-selenopurine and related compounds against some experimental mouse tumors, Cancer Res. 18:294–298.

    PubMed  CAS  Google Scholar 

  • McColl, K. E. L., Brodie, M. J., Whitesmith, R., Gray, K. F., and Thomson, T. J., 1979. Parotid salivary gland function in patients with exocrine pancreatic insufficiency, Acta Hepato-Gastroenterol. 26:407–412.

    CAS  Google Scholar 

  • McConnell, K. P., Broghamer, W. L., Blotcky, A. J., and Hurt, O. J., 1975. Selenium levels in human blood and tissues in health and in disease, J. Nutr. 105:1026–1031.

    PubMed  CAS  Google Scholar 

  • McConnell, K. P., Jagar, R. M., Higgins, P. J., and Blotcky, A. J., 1977. Serum selenium levels in patients with and without breast cancer, Proceedings of the 18th Meeting of the American College of Nutrition, Houston, Texas, J. Van Eys, M.S. Seelig, and B. L. Nichols, (eds), S. P. Medical and Scientific Books, New York, pp. 195–198.

    Google Scholar 

  • McConnell, K. P., Jager, R. M., Bland, K. I., and Blotcky, A. J., 1980. The relationship of idetary selenium and breast cancer, J. Surg. Oncol. 15:67–70.

    Article  PubMed  CAS  Google Scholar 

  • Medina, D., and Oborn, C. J., 1981. Differential effects of selenium on the growth of mouse mammary cells in vitro, Cancer Lett. 13:333–344.

    Article  PubMed  CAS  Google Scholar 

  • Medina, D., and Shepherd, F., 1981. Selenium-mediated inhibition of 7,12-dimethylbenzanthracene-induced mouse mammary tumorigenesis, Carcinogenesis 2:451–455.

    Article  PubMed  CAS  Google Scholar 

  • Meyers, C. E., McGuire, W. P., Liss, R., Ifrim, I., Frotzinger, K., and Young, R. C., 1976a. Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response, Science 197:165–167.

    Article  Google Scholar 

  • Milner, J. A., and Hsu, C. Y., 1981. Inhibitory effects of selenium on the growth of L1210 leukemic cells, Cancer Res. 41:1652–1656.

    PubMed  CAS  Google Scholar 

  • Mulhern, S. A., Morris, V. C., Vessey, A. R., and Levander, O. A., 1981. Influence of selenium and chow diets on immune function in first and second generation mice, Fed. Proc. Fed. Am. Soc. Exp. Biol. 40:935.

    Google Scholar 

  • Nakaidze, N. S., Kuzmin, V. I., Rozantsev, E. G., and Obukhova, L. G., 1979. Effect of some antioxidants on the life span of Drosophilia melanogaster, Izv. Akad. SSSR Ser. Biol. 6:926–929.

    Google Scholar 

  • Nakamuro, K., Yoshikawa, K., Sayato, Y., Kurata, H., Tonomura, M., and Tonomura, A., 1976. Studies on selenium-related compounds, V. Cytogenetic effect and reactivity with DNA, Mutation Res. 40:177–184.

    Article  PubMed  CAS  Google Scholar 

  • National Cancer Institute Carcinogenesis Test Program, 1980. Bioassay of selenium sulfide (gavage) for possible carcinogenicity, NIH Publ., NIH-80-1750, 130 pp.

    Google Scholar 

  • Navia, J. M., 1970. Effect of minerals on the dental caries. Dietary chemicals vs. dental caries, in Advances in Chemistry, R. S. Harris (ed.), American Chemical Society, Washington, D.C., pp. 123–160.

    Google Scholar 

  • Navia, J. M., Menaker, L., Seltzer, J., and Harris, R. S., 1968. Effect of Na2SeO3 supplemented in the diet or the water on dental caries of rats, Fed. Proc. Fed. Am. Soc. Exp. Biol. 27:676.

    Google Scholar 

  • Nelson, A. A., Fitzhugh, O. G., and Calvery, H. O., 1943. Liver tumors following cirrhosis caused by selenium in rats, Cancer Res. 3:230–236.

    CAS  Google Scholar 

  • Nickerson, W. J., Taber, W. A., and Falcone, G., 1956. Physiological bases of morphogenesis in fungi. 5. Effect of selenite and tellurite on cellular division of yeastlike fungi, Can. J. Microbiol. 2:575–584.

    Article  PubMed  CAS  Google Scholar 

  • Nixon, G. S., and Myers, V. B., 1970. Estimation of selenium in human dental enamel by activation analysis, Caries Res. 4:179–187.

    Article  PubMed  CAS  Google Scholar 

  • Noda, M., Takano, T., and Sakurai, H., 1979. Mutagenic activity of selenium compounds, Mutat. Res. 66:175–179.

    Article  PubMed  CAS  Google Scholar 

  • Norman, B. B., and Johnson, W., 1976. Selenium responsive disease, Anim. Nutr. Hlth. 31:6.

    Google Scholar 

  • Norppa, H., Westermarck, T., Laasonen, M., Knuutila, L., and Knuutila, S., 1980a. Chromosomal effects of sodium selenite in vivo. I. Aberrations and sister chromatid exchanges in human lymphocytes, Hereditas 93:93–96.

    Article  PubMed  CAS  Google Scholar 

  • Norppa, H., Westermarck, T., Oksanen, A., Rimaila-Parnanen, E., and Knuutila, S., 1980b. Chromosomal effects of sodium selenite in vivo. II. Aberrations in mouse bone marrow and primary spermatocytes, Hereditas 93:97–99.

    Article  PubMed  CAS  Google Scholar 

  • Norppa, H., Westermarck, T., and Knuutila, S., 1980c. Chromosomal effects of sodium selenite in vivo. III Aberrations and sister chromatid exchanges in Chinese hamster bone marrow, Hereditas 93:101–105.

    Article  PubMed  CAS  Google Scholar 

  • Ostadalova, I., Babicky, A., and Obenberger, J., 1977. Cataract induced by administration of a single dose of sodium selenite to suckling rats, Experientia 34:222–223.

    Google Scholar 

  • Perry, H. M., and Erlanger, M. W., 1977. Effect of a second metal on cadmium-induced hypertension, in Trace Substances in Environmental Health, Vol. 11, D. D. Hemphill (ed.), University of Missouri Press, Columbia, Missouri, pp. 280–288.

    Google Scholar 

  • Phillips, G. D., and Garnys, V. P., 1981. Trace element balance in adults receiving parenteral nutrition: Preliminary data, JPEN 5:11–14.

    Article  CAS  Google Scholar 

  • Pointner, H., and Kletter, K., 1980 Evaluation of the 75Se-l-selenomethionine test for pancreatic disease, Digestion 20:225–233.

    Article  PubMed  CAS  Google Scholar 

  • Poirier, K. A., and Milner, J. A., 1979. The effect of various seleno-compounds on Ehrlich ascites tumor cells, Biol. Jr. Elem. Res. 1:25–34.

    Article  CAS  Google Scholar 

  • Pories, W. J., Atawneh, A., Peer, R. M., Childers, R. C., Worland, R. L., Zaresky, S. A., and Strain, W. H., 1979. Mineral metabolism of the healing arterial wall, Arch. Surg. 114:254–257.

    Article  PubMed  CAS  Google Scholar 

  • Prowse, W. B., 1937. Carcinoma of breast with wide-spread metastases. Two cases of recovery, Brit. Med. J. 1:1021–1023.

    Article  PubMed  CAS  Google Scholar 

  • Randleman, C. D., 1980. Inhibitory effects of selenium on induced rat ovarian tumors, BIOS 51:86–89.

    CAS  Google Scholar 

  • Rasco, M. A., Jacobs, M. M., and Griffin, A. C., 1977. Effects of selenium on aryl hydrocarbon hydroxylase activity in cultured human lymphocytes, Cancer Lett. 3:295–301.

    Article  CAS  Google Scholar 

  • Ray, J. H., and Altenburg, L. C., 1978. Sister-chromatid exchange induction by sodium selenite: Dependence on the presence of red blood cells or red blood cell lysate, Mutation Res. 54:343–354.

    Article  PubMed  CAS  Google Scholar 

  • Ray, J. H., Altenburg, L. C., and Jacobs, M. M., 1978. Effects of sodium selenite and methyl methanesulphonate or N-hydroxy-2-acetylaminofluorene co-exposure on sister chromatid exchange production in human whole blood cultures, Mutat. Res. 57:359–368.

    PubMed  CAS  Google Scholar 

  • Reiss, U., Tappel, A. L., and Chio, K. S., 1972. DNA-malonaldehyde reaction: Formation of fluorescent products, Biochem. Biophys. Res. Commun. 48:921–926.

    Article  PubMed  CAS  Google Scholar 

  • Revis, N. W., and Armsted, B., 1979. The role of selenium and vitamin E in prevention of lipid peroxidation and myocardial necrosis induced by isoprenaline treatment of coronary artery ligation, International Congress Series no. 491, Florence International Meeting on Myocardial Infarction, Excerpta Medica, Amsterdam-Oxford-Princeton.

    Google Scholar 

  • Revis, N. W., and Marusic, N., 1978. Glutathione peroxidase activity and selenium concentration in the hearts of doxorubicin-treated rabbits, J. Molec. Cell. Card. 10:945–951.

    Article  CAS  Google Scholar 

  • Rhead, W. J., and Schneider, J. A., 1976. Effect of selenium compounds on selenium content, growth and 35S-cystine metabolism of skin fibroblasts from normal and cystinotic individuals, Bioinorg. Chem. 6:187–202.

    Article  PubMed  CAS  Google Scholar 

  • Riley, J. F., 1968. Mast cells, cocarcinogenesis and anti-carcinogenesis in the skin of mice, Experientia 15:1237–1238.

    Google Scholar 

  • Roberts, M. E., 1963a. Antiinflammation studies I. Antiinflammatory properties of liver fractions, Toxicol. Appl. Pharm 5:485–499.

    Article  CAS  Google Scholar 

  • Roberts, M. E., 1963b. Antiinflammation studies II. Antiinflammatory properties of selenium, Toxicol. Appl. Pharm. 5:500–506.

    Article  CAS  Google Scholar 

  • Robinson, M. F., Godfrey, P. J., Thomson, C. D., Rea, H. M., and van Rij, A. M., 1979. Blood selenium and glutathione peroxidase activity in normal subjects and in surgical patients with and without cancer in New Zealand, Am. J. Clin. Nutr. 32:1477–1485.

    PubMed  CAS  Google Scholar 

  • Rosin, M. P., 1981. Inhibition of spontaneous mutagenesis in yeast cultures by selenite, selenate and selenide, Cancer Lett. 13:7–14.

    Article  PubMed  CAS  Google Scholar 

  • Russell, G. R., Nader, C. J., and Patrick, E. J., 1980. Induction of DNA repair by some selenium compounds, Cancer Lett. 10:75–81.

    Article  PubMed  CAS  Google Scholar 

  • Schrauzer, G. N., Rhead, W. J., and Evans, G. A., 1973. Selenium and cancer: Chemical interpretation of a plasma “cancer test”, Bioinorg. Chem. 2:329–340.

    Article  CAS  Google Scholar 

  • Schrauzer, G. N., and Ishmael, D., 1974. Effects of selenium and of arsenic on the genesis of spontaneous mammary tumors in inbred C3H mice, Ann. Clin. Lab. Sci. 4:411–447.

    Google Scholar 

  • Schrauzer, G. N., White, D. A., and Schneider, C. J., 1976. Inhibition of the genesis of spontaneous mammary tumors in C3H mice: Effects of selenium and of selenium antagonistic elements and their possible role in human breast cancer, Bioinorg. Chem. 6:265–270.

    Article  PubMed  CAS  Google Scholar 

  • Schrauzer, G. N., White, D. A., and Schneider, C. J., 1977a. Cancer mortality correlation studies-III: Statistical associations with dietary selenium intakes, Bioinorg. Chem. 7:23–24.

    Article  PubMed  CAS  Google Scholar 

  • Schrauzer, G. N., White, D. A., and Schneider, C. J., 1977b. Cancer mortality correlation studies-IV: Associations with dietary intakes and blood levels of certain trace elements, notable Se-antagonists, Bioinorganic Chem. 7:35–56.

    Article  CAS  Google Scholar 

  • Schrauzer, G. N., White, D. A., and Schneider, C. J., 1978. Selenium and cancer: Effects of selenium and of the diet on the genesis of spontaneous mammary tumors in virgin inbred female C3H/St mice, Bioinorg. Chem. 8:387–396.

    Article  PubMed  CAS  Google Scholar 

  • Schrauzer, G. N., McGinness, J. E., and Kuehn, K., 1980. The effects of temporary selenium supplementation on the genesis of spontaneous mammary tumors in inbred female C3H/St mice, Carcinogenesis 1:199–201.

    Article  PubMed  CAS  Google Scholar 

  • Schrauzer, G. N., Kuehn, K., and Hamm, D., 1981. Effects of dietary selenium and lead on the genesis of spontaneous mammary tumors in mice, Biol. Tr. Elem. Res. 3:185–196.

    Article  CAS  Google Scholar 

  • Schut, H. A. J., and Thorgeirsson, S. S., 1979. Mutagenic activation of N-hydroxy-2-acetylaminofluorene by developing epithelial cells of rat small intestine and effects of antioxidants, J. Nat. Cancer Inst. 63:1405–1409.

    PubMed  CAS  Google Scholar 

  • Schroeder, H. A., and Mitchener, M., 1971. Selenium and tellurium in rats: Effects on growth, survival and tumors, J. Nutr. 101:1531–1540.

    PubMed  CAS  Google Scholar 

  • Schroeder, H., and Mitchener, M., 1972. Selenium and tellurium in mice, Arch. Environ. Health 24:66–71.

    PubMed  CAS  Google Scholar 

  • Schwarz, K., 1976. Essentiality and metabolic functions of selenium, Med. Clin. N. Am. 60:745–758.

    PubMed  CAS  Google Scholar 

  • Seifter, J., Ehrlich, W. E., Hudgma, G., and Mueller, G., 1946. Thyroid adenomas in rats receiving selenium, Science 103:762.

    Article  Google Scholar 

  • Serfass, R. E., and Ganther, H. E., 1976. Effects of dietary selenium and tocopherol on glutathione peroxidase and superoxide dismutase activities in rat phagocytes, Life Sci. 19:1139–1144.

    Article  PubMed  CAS  Google Scholar 

  • Shakelford, J., and Martin, J., 1980. Antibody response of mature male mice after drinking water supplemented with selenium, Fed. Proc. Fed. Am. Soc. Exp. Biol. 39:339.

    Google Scholar 

  • Shamberger, R. J., 1970. Relationship of selenium to cancer. I. Inhibitory effect of selenium on carcinogenesis, J. Nat. Cancer Inst. 44:931–936.

    PubMed  CAS  Google Scholar 

  • Shamberger, R. J., 1972. Increase of peroxidation in carcinogenesis, J. Nat. Cancer Inst. 48:1491–1497.

    PubMed  CAS  Google Scholar 

  • Shamberger, R. J., 1977. Antioxidants and Cancer. VII. Cadmium-seleniums in kidneys, in Proceedings of the 3rd International Symposium of Trace Element Metabolism in Man and Animals, M. Kirchgessner (ed.) Freising-Weihenstephen, West Germany, pp. 391–392.

    Google Scholar 

  • Shamberger, R. J., and Bratush, C. M., 1980. Cadmium, selenium and zinc levels in kidneys, Trace Substances in Environmental Health, Vol. 14, D. D. Hemphill (ed.), University of Missouri Press, Columbia, Missouri, pp. 203–210.

    Google Scholar 

  • Shamberger, R. J., and Rudolph, G., 1966. Protection against cocarcinogenesis by antioxidants, Experientia 22:116.

    Article  PubMed  CAS  Google Scholar 

  • Shamberger, R. J., and Willis, C. E., 1971. Selenium distribution and human cancer mortality, CRC Crit. Rev. Clin. Lab. Sci. 2:211–221.

    Article  PubMed  CAS  Google Scholar 

  • Shamberger, R. J., Baughman, F. F., Kalchert, S. L., Willis, C. E., and Hoffman, G. C., 1973b. Carcinogen-induced chromosomal breakage decreased by antioxidants, Proc. Nat. Acad Sci. 70:1461–1463.

    Article  PubMed  CAS  Google Scholar 

  • Shamberger, R. J., Rukovena, E., Longfield, A. K., Tytko, S. A., Deodhar, S., and Willis, C. E., 1973a, Antioxidants and cancer. I. Selenium in the blood of normals and cancer patients, J. Nat. Cancer Inst. 50:863–870.

    PubMed  CAS  Google Scholar 

  • Shamberger, R. J., Andreone, T. L., and Willis, C. E., 1974. Antioxidants and cancer. IV. Initiating activity of malonaldehyde as a carcinogen, J. Nat. Cancer Inst. 53:1771–1773.

    PubMed  CAS  Google Scholar 

  • Shamberger, R. J., Tytko, S. A., and Willis, C. E., 1975. Selenium and heart disease, in Trace Substances in Environmental Health, Vol. 9, D. D. Hemphill (ed.), University of Missouri Press, Columbia, Missouri, pp. 15–22.

    Google Scholar 

  • Shamberger, R. J., Tytko, S. A., and Willis, C. E., 1976. Antioxidants and cancer. Part VI. Selenium and age-adjusted human cancer mortality, Arch. Environ. Health 31:231–235.

    PubMed  CAS  Google Scholar 

  • Shamberger, R. J., Gunsch, M. S., Willis, C. E., and McCormack, L. J., 1978. Selenium and heart disease. II. Selenium and other trace metal intakes and heart disease in 25 countries, in Trace Substances in Environmental Health, Vol. 12, D. D. Hemphill (ed.), University of Missouri Press, Columbia, Missouri, pp. 48–52.

    Google Scholar 

  • Shamberger, R. J., Corlett, C. L., Beaman, K. D., and Kasten, B. L., 1979a. Antioxidants reduce the mutagenic effect of malonaldehyde and β-propiolactone, Part IX. Antioxidants and Cancer, Mutat. Res. 66:349–355.

    Article  PubMed  CAS  Google Scholar 

  • Shamberger, R. J., Willis, C. E., and McCormack, L. J., 1979b. Selenium and heart disease. III. Blood selenium and heart mortality in 19 states, in Trace Substances in Environmental Health, Vol. 13, D. D. Hemphill (ed.), University of Missouri Press, Columbia, Missouri, pp. 59–63.

    Google Scholar 

  • Shapiro, J. R., 1972. Selenium and carcinogenesis: A review, Ann. N. Y. Acad. Sci. 192:215–219.

    Article  PubMed  CAS  Google Scholar 

  • Shearer, T. R., 1973. Comparative distribution of 75Se in the hard and soft tissues of mother rats and their pups, J. Nutr. 103:553–559.

    PubMed  CAS  Google Scholar 

  • Shearer, T. R., 1975. Developmental and postdevelopmental uptake of dietary organic and inorganic selenium into the molar teeth of rats, J. Nutr. 105:338–346.

    PubMed  CAS  Google Scholar 

  • Shearer, T. R., and Ridlington, J. W., 1976. Fluoride-selenium interaction in the hard and soft tissues of the rat, J. Nutr. 106:451–456.

    PubMed  CAS  Google Scholar 

  • Shearer, T. R., McCormack, D. W., Destart, D. J., Britton, J. L., and Lopez, M. T., 1980. Histological evaluation of selenium induced cataracts, Exp. Eye Res. 31:327–333.

    Article  PubMed  CAS  Google Scholar 

  • Sheffy, B. E., and Schultz, R. D., 1978. Influence of vitamin E and selenium on immune response mechanisms, Cornell Vet. 68 Suppl. 7:89–93.

    Google Scholar 

  • Shukla, V. K. S., Jensen, G. E., and Clausen, J., 1977. Erythrocyte glutathione deficiency in multiple sclerosis, Acta Neurol. Scandinav. 56:542–550.

    Article  CAS  Google Scholar 

  • Shukla, V. K. S., Jensen, G. E., and Clausen, J., 1978. Serum fatty acids and peroxidase abnormalities in Batten’s disease, Res. Exp. Med. 173:27–34.

    Article  CAS  Google Scholar 

  • Soullier, B. K., Wilson, P. S., and Nigro, N. D., 1981. Effect of selenium on azoxymethane-induced intestinal cancer in rats fed high fat diet, Cancer Lett. 12:343–348.

    Article  PubMed  CAS  Google Scholar 

  • Spallholz, J. E., 1981. Anti-inflammatory, immunologic and carcinostatic attributes of selenium in experimental animals, Adv. Exp. Med. Biol., 135:43–62.

    CAS  Google Scholar 

  • Spallholz, J. E., Martin, J. L., Gerlach, M. L., and Heinzerling, R. H., 1973a. Immunological responses of mice fed diets supplemented with selenite selenium, Proc. Soc. Exp. Biol. Med. 143:685–689.

    PubMed  CAS  Google Scholar 

  • Spallholz, J. E., Martin, J. L., Gerlach, M. L., and Heizerling, R. H., 1973b. Enhanced IgM and IgG titers in mice fed selenium, Infec. Immun. 8:841–842.

    CAS  Google Scholar 

  • Spallholz, J. E., Heinzerling, R. H., Gerlach, M. L., and Martin, J. L., 1974. The effect of selenite, tocopherol acetate and selenite, tocopherol acetate on the primary and secondary immune responses of mice administered tetanus toxoid or sheep red blood cell antigen, Fed. Proc. Fed. Am. Soc. Exp. Biol. 33:694.

    Google Scholar 

  • Spallholz, J. E., Martin, J. L., Gerlach, M. L., and Heizerling, R. H., 1975. Injectable selenium: Effect on the primary immune response of mice, Proc. Soc. Exp. Biol. Med. 148:37–40.

    PubMed  CAS  Google Scholar 

  • Strehler, B. L., Mark, D. D., Mildvan, A. S., and Gee, M. V., 1959. Rate and magnitude of age pigment accumulation in the human myocardium, J. Gerontol. 14:430–439.

    Article  PubMed  CAS  Google Scholar 

  • Tappel, A. L., 1972. Vitamin E and free-radical peroxidation of lipids, Ann. N. Y. Acad. Sci. 203:12–28.

    Article  PubMed  CAS  Google Scholar 

  • Thomson, C. D., Rea, H. M., Robinson, M. F., and Simpson, F. O., 1978. Selenium concentrations and glutathione peroxidase activities in the blood of hypertensive patients, Proc. Univ. Otago Med. Sch. 56:31–33.

    CAS  Google Scholar 

  • Thompson, H. J., and Becci, P. J., 1979. Effect of graded dietary levels of selenium on tracheal carcinomas induced by 1-methyl-1-nitrosourea, Cancer Lett. 7:215–219.

    Article  PubMed  CAS  Google Scholar 

  • Thompson, H. J., and Becci, P. J., 1980. Selenium inhibition of N-methyl-N-nitrosourea-induced mammary carcinogenesis in the rat, J. Nat. Cancer Inst. 65:1299–1301.

    PubMed  CAS  Google Scholar 

  • Thompson, H. J., and Taglaferro, A. R., 1980. Effect of selenium on 7,12-dimethylbenzan-thracene-induced mammary tumorigenesis, Fed. Proc. Fed. Am. Soc. Exp. Biol. 39:1117.

    Google Scholar 

  • Thompson, H. J., Soule, R. A., and Becci, P. J., 1981b. Inhibition of mammary tumorigenesis by graded levels of selenium, Fed. Proc. Fed. Am. Soc. Exp. Biol. 40:929.

    Google Scholar 

  • Thompson, H. J., Meeker, L. D., and Becci, P. J., 1981a. Effect of combined selenium and retinyl acetate treatment on mammary carcinogenesis, Cancer Res. 41:1413–1416.

    PubMed  CAS  Google Scholar 

  • Tkeshelashvili, L. K., Shearman, C. W., Zakour, R. A., Koplitz, R. M., and Loeb, L. A., 1980. Effects of arsenic, selenium, and chromium on the fidelty of DNA, Cancer Res. 40:2455–2460.

    PubMed  CAS  Google Scholar 

  • van Rij, A. M., McKenzie, J. M., Robinson, M. F., and Thomson, C. U., 1974. Selenium and total parenteral nutrition, JPEN 3:235–239.

    Google Scholar 

  • van Rij, A. M., Thomson, C. D., McKenzie, J. M., and Robinson, M. F., 1979. Selenium deficiency in total parenteral nutrition, Am. J. Clin. Nutr. 32:2076–2085.

    PubMed  Google Scholar 

  • Van Vleet, J. F., Rebar, A. H., and Ferrans, V. J., 1977. Acute cobalt and isoproterenol cardiotoxicity in swine: Protection by selenium-vitamin E supplementation and and potentiation by stress-susceptible phenotype, Am. J. Vet. Res. 38:991–1002.

    PubMed  Google Scholar 

  • Van Vleet, J. F., and Ferrans, V. J., 1980. Clinical observations, cutaneous lesions, and hematologic alterations in chronic adriamycin intoxication in dogs with and without vitamin E and selenium supplementation, Am. J. Vet. Res. 40:691–699.

    Google Scholar 

  • Van Vleet, J. F., Greenwood, L. A., and Rebar, A. H., 1981. Effect of selenium-vitamin E on hematologic alterations of adriamycin, toxicosis in young pigs, Am. J. Vet. Res. 42:1153–1159.

    PubMed  Google Scholar 

  • Villalon, J. A. M., M. D. thesis, Universidad Michocana de San Nicolas de Hilago, Mexico, cited by D. V. Frost and P. M. Lish, 1975, Selenium in biology, Ann. Rev. Pharm. 15:259–284.

    Google Scholar 

  • Volgarev, N. N., and Tscherkes, L. A., 1967. Further studies in tissue changes associated with sodium selenate, in Symposium: Selenium in Biomedicine, O. H. Muth (ed.), Avi Publishing Co., Westport, Connecticut, pp. 179–184.

    Google Scholar 

  • Voors, A. W., Johnson, W. D., Shuman, M. S., and Blotcky, A. J., 1978. Adjusted cadmium levels in the renal cortex and heart weight at autopsy, in Trace Substances in Environmental Health, Vol. 12, D. D. Hemphill (ed.), University of Missouri Press, Columbia, Missouri, pp. 181–190.

    Google Scholar 

  • Walker, G. W. R., and Ting, K. P., 1967. Effect of selenium on recombination in barley, Can. J. Genet. Cytol. 9:314–320.

    PubMed  CAS  Google Scholar 

  • Wallach, J. D., and Garmaise, B., 1979. Cystic fibrosis: A perinatal manifestation of selenium deficiency, in Trace Substances in Environmental Health, D. D. Hemphill (ed.), Uniersity of Missouri Press, Columbia, Missouri, pp. 469–476.

    Google Scholar 

  • Watson-Williams, E., 1920. The treatment of inoperable cancer with selenium, Brit. J. Surg. 8:50–58.

    Article  Google Scholar 

  • Welsch, C. W., Goodrich-Smith, M., Brown, C. K., Greene, H. D., and Hamel, E. J., 1981, Selenium and the genesis of murine mammary tumors, Carcinogenesis 2:519–522.

    Article  PubMed  CAS  Google Scholar 

  • Wester, P. O., Brune, D., and Nordberg, G., 1981. Arsenic and selenium in lung, liver and kidney tissue from dead smelter workers, Br. J. Ind. Med. 38:179–184.

    PubMed  CAS  Google Scholar 

  • Westermarck, T., 1977. Selenium content of tissues in Finnish infants and adults with various diseases, and studies on the effects of selenium supplementation in neuronal ceroid lipofuscinosis patients, Acta Pharmacol. Toxicol. 41:121–128.

    Article  CAS  Google Scholar 

  • Whanger, P. D., and Weswig, P. H., 1975. Effects of selenium, chromium, and antioxidants on growth, eye cataracts, plasma cholesterol, and blood glucose in selenium deficient, vitamin A supplemented rats, Nutr. Repts. Int. 12:345–357.

    CAS  Google Scholar 

  • Whanger, P. D., Pederson, N. D., Hatfield, J., Weswig, P. H., 1976. Absorption of selenite and selenomethionine from ligated digestive tract segments in rats, Proc. Soc. Exp. Biol. Med. 153:295–297.

    PubMed  CAS  Google Scholar 

  • Whiting, R. F., Wei, L., and Stich, H. F., 1980. Unscheduled DNA synthesis and chromosome aberrations induced by inorganic and organic selenium compounds in the presence of glutathione, Mutation Res. 78:159–169.

    Article  PubMed  CAS  Google Scholar 

  • Wikstom, J., Westermarck, T., and Palo, J., 1976. Selenium, vitamin E and copper in multiple sclerosis, Acta Neurol. Scand. 54:287–290.

    Article  Google Scholar 

  • Williams, G. M., 1978. Further improvements in the hepatocyte primary culture DNA repair test for carcinogens: Detection of carcinogenic biphenyl derivatives, Cancer Lett. 4:69–75.

    Article  PubMed  CAS  Google Scholar 

  • Wortzman, M. S., Besbris, H. J., and Cohen, A. M., 1980. Effect of dietary selenium on the interaction between 2-acetylaminofluorene and rat liver DNA in vivo, Cancer Res. 40:2670–2676.

    PubMed  CAS  Google Scholar 

  • Young, D. M., 1975. Pathologic effects of adriamycin (NSC-123-127) in experimental systems, Cancer Chemother. Rep. 6:159–175.

    CAS  Google Scholar 

  • Young, E. O., and Milner, J. A., 1981. Inhibition of 7,12-dimethylbenzanthracene-induced mammary tumors by selenium, Fed. Proc. Fed. Am. Soc. Exp. Biol. 40:949.

    Google Scholar 

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Shamberger, R.J. (1983). Selenium in Health and Disease. In: Biochemistry of Selenium. Biochemistry of the Elements, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4313-4_8

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