Features of Gene Structure, Organization, and Expression That Are Providing Unique Insights into Molecular Evolution and Systematics

  • David Hewett-Emmett
  • Patrick J. Venta
  • Richard E. Tashian
Part of the Monographs in Evolutionary Biology book series (MEBI)


Over the last 20 or so years, the study of amino acid sequences of proteins derived from different biologic species has greatly enriched our knowledge of both the mechanisms of molecular evolution and the phylogenetic relationships of the species. Increasingly sophisticated computer techniques have been employed in an effort to extract all of the phylogenetic information contained in such data sets. Several problems have arisen along the way, among the most persistent being the uncertainty of whether two sequences are truly orthologous and the species divergence is being examined, or whether they are paralogous and the gene divergences are being examined. Indeed, where gross discrepancies between gene phylogeny and species phylogeny occur, the probability is that paralogous genes are involved (Goodman, 1981; Goodman et al., this volume, Chapter 4).


Gene Duplication Molecular Evolution World Monkey Noncoding Region Globin Gene 


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • David Hewett-Emmett
    • 1
  • Patrick J. Venta
    • 1
  • Richard E. Tashian
    • 1
  1. 1.Department of Human GeneticsUniversity of Michigan Medical SchoolAnn ArborUSA

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