Nonuniform Molecular Divergence

The Quantitative Evolutionary Analysis of Genes and Messenger RNAs under Selective Structural Constraints
  • Richard Holmquist
  • Thomas H. Jukes
  • Dennis Pearl
Part of the Monographs in Evolutionary Biology book series (MEBI)


The divergence of species is accompanied by molecular changes in the primary structure of genes and their messenger RNA products. In the present chapter we consider the simplest of such changes, those caused by point mutation: the replacement of one nucleoside—adenosine (A), cytidine (C), guanosine (G), or thymidine (T)—by another and fixation of that replacement by natural selection or by random drift.


Random Model Fixation Intensity Evolutionary Parameter Codon Site Polyoma Virus 


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Richard Holmquist
    • 1
  • Thomas H. Jukes
    • 1
  • Dennis Pearl
    • 2
  1. 1.Space Sciences LaboratoryUniversity of California at BerkeleyBerkeleyUSA
  2. 2.Department of StatisticsUniversity of California at BerkeleyBerkeleyUSA

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