Distinct Acylhydrolase and PG Synthase Systems in the Perfused Rabbit Kidney

Selective Activation by Vasoactive Peptide Hormones and by Adenine Nucleotides
  • Amiram Raz
  • Michal Schwartzman


The endogenous generation of prostaglandins (PGs) and other oxygenated products of arachidonic acid is a complex process which involves acylhydrolase action to generate unesterified arachidonic acid and subsequent conversion to cell-specific oxygenated products. Control of this process can occur at several key steps, including the following: (1) the cellular site for agonist recognition and interaction, (2) the lipolytic step, (3) the extent of metabolic coupling between the released arachidonate and its transformation to oxygenated products, (4) the types of arachidonate metabolizing enzymes in the particular tissue or cell affected, and (5) other related reactions. In this report we employ the ureter-obstructed kidney model for the comparative study of the lipolytic and PG synthetic mechanism which are stimulated by the peptide hormones bradykinin and angiotensin II, the adenine nucleotides ATP and ADP, and by exogenous administration of unesterified arachidonic acid.


Arachidonic Acid Peptide Hormone Purinergic Receptor Effluent Sample Rabbit Kidney 
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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • Amiram Raz
    • 1
  • Michal Schwartzman
    • 1
  1. 1.Department of Biochemistry, The George S. Wise Center of Life SciencesTel Aviv UniversityIsrael

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