Biosynthesis of Prostaglandins and Thromboxanes in the Dog Kidney
It has been postulated that renal tissue may convert arachidonic acid (AA) to several prostaglandins (PGs) as well as thromboxane (TX) A2, because this tissue contains a comparatively large amount of AA1 and also significant amounts of the cyclooxygenase enzyme in the various areas of the kidney.2 Actually, PGE2 and PGF2α, known as renal PG, are mainly synthesized in the medulla of all the laboratory animals examined and in humans.3,4 The biosynthesis of PGI2 has been demonstrated in the cortex of rats and rabbits.5,6 TXA2, another AA metabolite, was detected only in kidneys with an obvious pathological status.7,8 Although there is considerable agreement with regard to the compartmentalization of PGI2 and the virtual absence of TXA2 biosynthesis within the kidney, recent experiments revealed that PGI2 was also a renomedullary PG, as are PGE2 and PGF2α,4,9–12 and that human renal microsomes synthesized significant amounts of TXA2, measured as TXB2.4
KeywordsArachidonic Acid Secretion Rate Ureteral Obstruction Arachidonic Acid Metabolite Rabbit Kidney
Unable to display preview. Download preview PDF.
- 3.Dunn MJ, Hood VL: Prostaglandins and the kidney. Am J Physiol 233: F169 - F184, 1977.Google Scholar
- 14.Moncada S, Vane JR: Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin. Pharmacol Rev 30: 293–331, 1979.Google Scholar
- 15.Barger AC, Herd JA: Renal vascular anatomy and distribution of blood flow, in Orloff J, Berliner RW (eds): Renal Physiology. Washington, DC, American Physiological Society, 1973, p 249.Google Scholar