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The Role of Renal Prostaglandin E in the Mechanism of the Exaggerated Fractional Na Excretion in Hypertensive Patients with Advanced Renal Disease

  • Keishi Abe
  • Makito Sato
  • Toshiaki Haruyama
  • Ko Sato
  • Masahide Seino
  • Minoru Yasujima
  • Yutaka Imai
  • Masao Hiwatari
  • Yutaka Kasai
  • Jiro Tajima
  • Sadayoshi Ito
  • Kaoru Yoshinaga

Abstract

Prostaglandin E (PGE) is a vasodilatory and natriuretic substance which is synthesized in the renomedullary interstitial cell and collecting tubule.1–3 Previous experimental and theoretical studies have shown a reduced clearance of sodium and water in renal hypertension.4 On the other hand, it is well known that sodium excretion per nephron varies inversely with the number of constituent nephrons, and that reduction of renal excretory function due to renal parenchymal disease is associated with exaggerated fractional sodium excretion.5 Since PGE can induce natriuresis, there is a possibility that renal PGE may contribute to the mechanism of exaggerated fractional sodium excretion in hypertensive patients with end-stage renal disease. The present study was performed to investigate this possibility.

Keywords

Plasma Renin Activity Sodium Excretion Plasma Aldosterone Concentration Renal Hypertension Sustained Hypertension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • Keishi Abe
    • 1
  • Makito Sato
    • 1
  • Toshiaki Haruyama
    • 1
  • Ko Sato
    • 1
  • Masahide Seino
    • 1
  • Minoru Yasujima
    • 1
  • Yutaka Imai
    • 1
  • Masao Hiwatari
    • 1
  • Yutaka Kasai
    • 1
  • Jiro Tajima
    • 1
  • Sadayoshi Ito
    • 1
  • Kaoru Yoshinaga
    • 1
  1. 1.Department of Internal MedicineTohoku University School of MedicineSendaiJapan

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