The Role of Arachidonic Acid Metabolites in the Pathophysiology of Bartter’s Syndrome

  • Jeffrey S. Stoff
  • David M. Clive
  • Diane Leone
  • D. Euan MacIntyre
  • Robert S. Brown
  • Edwin Salzman


Almost 20 years ago Frederic Bartter, John Gill, and their co-workers described an unusual form of secondary hyperaldosteronism in two children.1 Their patients had a number of clinical and metabolic abnormalities which characterize the syndrome now referred to as Bartter’s syndrome. The clinical features of this syndrome are illustrated in Table I.


Prostaglandin Synthesis Renin Release Potassium Depletion Platelet Inhibitory Activity Antiaggregatory Activity 
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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • Jeffrey S. Stoff
    • 1
  • David M. Clive
    • 1
  • Diane Leone
    • 1
  • D. Euan MacIntyre
    • 2
  • Robert S. Brown
    • 1
  • Edwin Salzman
    • 2
  1. 1.Charles A. Dana Research Institute and the Harvard-Thorndike Laboratory of the Departments of Medicine and SurgeryBeth Israel HospitalBostonUSA
  2. 2.Department of SurgeryHarvard Medical School, Beth Israel HospitalBostonUSA

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