Platelet Prostaglandin Production in the Nephrotic Syndrome
Femoral, mesenteric, inferior vena cava, and particularly renal vein thrombosis are reported as complications in nephrotic syndrome (NS) patients.1–3 Among the primary form(s) of NS, membranous and membranoproliferative glomerulonephritides are more frequently associated with thrombotic episodes, while among secondary forms, thrombosis particularly occurs in patients with amyloidosis.4 The incidence of coronary artery disease in NS patients is a controversial issue.5,6 However, besides hypercoagulability, the existence of other risk factors, such as Frederickson type Ha, lib, and IV hyperlipoproteinemias7 and high blood pressure, is generally accepted and should be taken into account.
KeywordsArachidonic Acid Nephrotic Syndrome Membranoproliferative Glomerulonephritis Renal Vein Thrombosis Washed Platelet
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- 7.Newar SR, Anderson CF, Donadio JV, et al: Lipoprotein profiles in adult nephrotics. Mayo Clin Proc 50: 359, 1975.Google Scholar
- 8.Kanfer A, Kleinknecht D, Broyer M, et al: Coagulation studies in 45 cases of nephrotic syndrome without uremia. Thromb Haemost 24: 562, 1978.Google Scholar
- 16.Silver MJ, Smith JB, McKean ML, et al: Prostaglandins and thromboxane: current concepts, in Remuzzi G, Mecca G, deGaetano G, (eds): Hemostasis, Prostaglandins and Renal Disease. New York, Raven Press, 1980, p 159.Google Scholar