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The Role of Thromboxanes in Renal Disease

  • Aubrey R. Morrison
  • Julio E. Benabe
  • Alan Taylor

Abstract

The thromboxanes constitute a family of carboxylic acids containing an oxane ring. They are formed from the prostaglandin endoperoxides enzymatically by the enzyme thromboxane synthetase. Thromboxane biosynthesis has been demonstrated in several biological tissues, e.g., platelets,1,2 lung,3 spleen,4 stomach,5 brain,6 and kidney.7–9 The biologically active species thromboxane A2 is a C-20 carboxylic acid containng an oxetane-oxane structure and is derived from the parent fatty acid 5,8,11,14-eicosatetraenoic acid (arachidonic acid). Thromboxane A2 is rapidly converted to thromboxane B2 by addition of H2O (t 1/2 in aqueous media at 37°, 30–40 sec). This shortlived compound owes its biological interest mainly to two characteristics: (1) In the platelet it is produced during aggregation, and inhibition of its production is associated with inhibition of aggregation and (2) it is a potent constrictor of smooth muscle (rabbit aorta-contracting substance) and its production has been implicated in the vasocontriction which mediates the reduction in blood flow associated with platelet vascular homeostasis.

Keywords

Renal Blood Flow Unilateral Ureteral Obstruction Ureteral Obstruction Rabbit Kidney Prostaglandin Endoperoxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • Aubrey R. Morrison
    • 1
  • Julio E. Benabe
    • 1
  • Alan Taylor
    • 1
  1. 1.Departments of Medicine and PharmacologyWashington University School of MedicineSt. LouisUSA

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