Prostaglandins and Renal Function after Chronic Ligation of the Common Bile Duct in Dogs

  • Edward J. Zambraski
  • Michael J. Dunn


In severe liver disease there can be associated alterations in renal function. These abnormalities include decreased RBF and GFR, sodium retention, decreased capacity to concentrate the urine, and redistribution of renal blood flow away from the outer cortex.1–3 Severe cirrhosis and ascites can ultimately cause progressive renal failure, the so-called hepatorenal syndrome. The mechanisms responsible for the deterioration of renal function are not clearly understood.


Common Bile Duct Mean Arterial Pressure Plasma Renin Activity Renal Blood Flow Sodium Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.





prostaglandin E2


prostaglandin F


6-keto-prostaglandin F

6,15 DK-13,14-DH-PGF

6,15-diketo- 13,14-dihydro-PGF


prostacyclin or prostaglandin I2


chronic bile duct ligation


glomerular filtration rate


renal blood flow


mean arterial pressure


renal vascular resistance.


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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • Edward J. Zambraski
    • 1
  • Michael J. Dunn
    • 2
    • 3
  1. 1.Department of PhysiologyRutgers UniversityNew BrunswickUSA
  2. 2.Department of MedicineCase Western Reserve UniversityClevelandUSA
  3. 3.Division of NephrologyUniversity Hospitals of ClevelandClevelandUSA

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