The Effect of Indomethacin on Renal Function and Glomerular Protein Loss

  • Ab J. Donker


In 1955 Fieschi and Bianchi published the paper “Il fenilbutazone: Un farmaco attivo sulla albuminuria,” in which they described their experiences with phenylbutazone in patients with proteinuria. A decrease in protein excretion and an increase in plasma albumin concentration were observed in 21 out of 25 patients with the nephrotic syndrome.1 Also the late Professor J. G. G. Borst did extensive research at that time in Amsterdam on the effects of phenylbutazone and aminophenazone in patients with adrenocorticotropic hormone- (ACTH) resistant nephrotic syndrome. He noticed that the decrease in urinary protein loss induced by these drugs was often associated with a decrease in the clearance of creatinine.2 Serious side effects of phenylbutazone and aminophenazone, however, ultimately limited both general application in and longterm treatment of patients with steroid-resistant severe proteinuria.


Nephrotic Syndrome Sodium Restriction Effective Renal Plasma Flow Sodium Depletion Antiproteinuric Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • Ab J. Donker
    • 1
    • 2
  1. 1.Academisch ZiekenhuisGroningenThe Netherlands
  2. 2.Afdeling InterneGroningenThe Netherlands

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