Diuretics and Kidney Prostaglandins

  • Uffe Bang Olsen


The kidney is an organ with a great capacity for prostaglandin synthesis. Close renal intra-arterial infusion of arachidonic acid increases renal blood flow and enhances salt and water excretion. In contrast, in most conditions inhibition of prostaglandin synthesis by nonsteroidal anti-inflammatory drugs produces salt and water retention in association with reductions of the renal blood flow.


Renal Blood Flow Loop Diuretic Prostaglandin Synthesis Ethacrynic Acid Diuretic Effect 
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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • Uffe Bang Olsen
    • 1
  1. 1.Department of PharmacologyLeo Pharmaceutical ProductsBallerupDenmark

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