Prostaglandin E2 (PGE2) in Renal Papilla in NaCl Hypertension
Human essential hypertension is clearly dependent on sodium intake and excretion.1 This “sodium connection” stimulated us to investigate prostaglandin E2 (PGE2) in the renal papillae of two strains of rats, the Dahl S strain, which is highly susceptible to salt-induced hypertension, and the Dahl R strain, which is highly resistant to salt hypertension.2 As seen in Fig. 1, when both strains are on a low-salt diet with 0.3% NaC1, neither strain has blood pressures (BPs) out of the normal range; however, when the two strains begin eating a high salt intake of 4% NaC1, the R strain has no rise of BP at all, while the S strain becomes mildly hypertensive at 4 weeks and solidly hypertensive by 11 weeks.
KeywordsPGE2 Level PGE2 Concentration High Salt Intake Renal Papilla Linoleic Diet
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- 3.Tobian L, Lange J, Azar S, et al: Reduction of natriuretic capacity and renin release in isolated bloodperfused kidneys of Dahl hypertension-prone rats. Circ Res Suppl 43: 92–98, 1978.Google Scholar
- 4.Stokes JB: Tubular actions of arachidonic acid metabolites: Effects on NaCl and water transport. This volume, 1982.Google Scholar