Prostaglandin E2 (PGE2) in Renal Papilla in NaCl Hypertension

  • Louis Tobian


Human essential hypertension is clearly dependent on sodium intake and excretion.1 This “sodium connection” stimulated us to investigate prostaglandin E2 (PGE2) in the renal papillae of two strains of rats, the Dahl S strain, which is highly susceptible to salt-induced hypertension, and the Dahl R strain, which is highly resistant to salt hypertension.2 As seen in Fig. 1, when both strains are on a low-salt diet with 0.3% NaC1, neither strain has blood pressures (BPs) out of the normal range; however, when the two strains begin eating a high salt intake of 4% NaC1, the R strain has no rise of BP at all, while the S strain becomes mildly hypertensive at 4 weeks and solidly hypertensive by 11 weeks.


PGE2 Level PGE2 Concentration High Salt Intake Renal Papilla Linoleic Diet 
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  1. 1.
    Tobian L: The relationship of salt to hypertension. Am J Clin Nutr 32: 2739–2748, 1979.PubMedGoogle Scholar
  2. 2.
    Dahl LK, Heine M, Tassinari L: Effects of chronic excess salt ingestion: Evidence that genetic factors play an important role in susceptibility to experimental hypertension. J Exp Med 115: 1173–1190, 1962.PubMedCrossRefGoogle Scholar
  3. 3.
    Tobian L, Lange J, Azar S, et al: Reduction of natriuretic capacity and renin release in isolated bloodperfused kidneys of Dahl hypertension-prone rats. Circ Res Suppl 43: 92–98, 1978.Google Scholar
  4. 4.
    Stokes JB: Tubular actions of arachidonic acid metabolites: Effects on NaCl and water transport. This volume, 1982.Google Scholar
  5. 4a.
    Stokes JB, Tisher CC, Kokko JP: Structural-functional heterogeneity along the rabbit collecting tubule. Kidney Int 14 (6): 585, 1973.CrossRefGoogle Scholar
  6. 4b.
    Stokes JB: Effects of prostaglandin E2 on chloride transport across the rabbit thick ascending limb of Henle. Selective inhibitions of the medullary portion. J Clin Invest 64 (2): 495, 1979.PubMedCrossRefGoogle Scholar
  7. 5.
    Rosenthal J, Simone P, Silbergleit A: Effects of prostaglandin deficiency on natriuresis, diuresis, and blood pressure. Prostaglandins 5: 435–440, 1979.CrossRefGoogle Scholar
  8. 6.
    Ganguli M, Tobian L, Dahl L: Low renal papillary plasma flow in both Dahl and Kyoto rats with spontaneous hypertension. Circ Res 39: 337, 1976.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • Louis Tobian
    • 1
  1. 1.University of Minnesota HospitalMinneapolisUSA

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