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Prostaglandin E2 (PGE2) in Renal Papilla in NaCl Hypertension

  • Louis Tobian

Abstract

Human essential hypertension is clearly dependent on sodium intake and excretion.1 This “sodium connection” stimulated us to investigate prostaglandin E2 (PGE2) in the renal papillae of two strains of rats, the Dahl S strain, which is highly susceptible to salt-induced hypertension, and the Dahl R strain, which is highly resistant to salt hypertension.2 As seen in Fig. 1, when both strains are on a low-salt diet with 0.3% NaC1, neither strain has blood pressures (BPs) out of the normal range; however, when the two strains begin eating a high salt intake of 4% NaC1, the R strain has no rise of BP at all, while the S strain becomes mildly hypertensive at 4 weeks and solidly hypertensive by 11 weeks.

Keywords

PGE2 Level PGE2 Concentration High Salt Intake Renal Papilla Linoleic Diet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • Louis Tobian
    • 1
  1. 1.University of Minnesota HospitalMinneapolisUSA

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