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Neural Control of Renin Secretion

Role of Prostaglandins
  • Jeffrey L. Osborn
  • Marc D. Thames
  • Gerald F. DiBona

Abstract

The renal sympathetic nerves have been shown to be an important pathway regulating renin1 and prostaglandin2 release from the kidney. We recently reported that direct electrical stimulation of the kidney nerves at 0.5 Hz increases renin secretion rate without altering mean arterial pressure, renal blood flow, glomerular filtration rate, or urinary sodium excretion.3 We have interpreted this result as evidence for a direct action of the renal nerves on the juxtaglomerular granular cells to increase renin secretion. In addition to a direct influence on renin secretion, subthreshold levels of renal nerve stimulation augment the renin secretion rate response to nonneural stimuli and innervated kidneys have a higher renin secretion rate response to suprarenal aortic constriction than denervated kidneys.4 Since renal nerve stimulation results in the release of renal prostaglandins, we hypothesized that intrarenal prostaglandins may be an important mediator of renin secretion during renal nerve stimulation.

Keywords

Renal Blood Flow Urinary Sodium Excretion Renin Secretion Renal Nerve Direct Electrical Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Davis JO, Freeman RH: Mechanisms regulating renin release. Physiol Rev 56: 1–56, 1976.PubMedGoogle Scholar
  2. 2.
    Dunham EW, Zimmerman BG: Release of prostaglandin-like material from dog kidney during nerve stimulation. Am J Physiol 219: 1279–1285, 1970.PubMedGoogle Scholar
  3. 3.
    Osborn JL, DiBona GF, Thames MD: Beta-1 receptor mediation of renin secretion elicited by low frequency renal nerve stimulation. J Pharmacol Exp Ther 216: 265–269, 1981.PubMedGoogle Scholar
  4. 4.
    Thames MD, DiBona GF: Renal nerves modulate the secretion of renin mediated by nonneural mechanisms. Circ Res 44: 645–652, 1979.PubMedGoogle Scholar
  5. 5.
    Data JL, Gerber JG, Crump WL, et al: The prostaglandin system: A role in canine baroreceptor control of renin release. Circ Res 42: 454–458, 1978.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • Jeffrey L. Osborn
    • 1
  • Marc D. Thames
    • 1
  • Gerald F. DiBona
    • 1
  1. 1.Department of Internal MedicineUniversity of Iowa College of Medicine and Veterans Administration Medical CenterIowa CityUSA

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