Neural Control of Renin Secretion
The renal sympathetic nerves have been shown to be an important pathway regulating renin1 and prostaglandin2 release from the kidney. We recently reported that direct electrical stimulation of the kidney nerves at 0.5 Hz increases renin secretion rate without altering mean arterial pressure, renal blood flow, glomerular filtration rate, or urinary sodium excretion.3 We have interpreted this result as evidence for a direct action of the renal nerves on the juxtaglomerular granular cells to increase renin secretion. In addition to a direct influence on renin secretion, subthreshold levels of renal nerve stimulation augment the renin secretion rate response to nonneural stimuli and innervated kidneys have a higher renin secretion rate response to suprarenal aortic constriction than denervated kidneys.4 Since renal nerve stimulation results in the release of renal prostaglandins, we hypothesized that intrarenal prostaglandins may be an important mediator of renin secretion during renal nerve stimulation.
KeywordsRenal Blood Flow Urinary Sodium Excretion Renin Secretion Renal Nerve Direct Electrical Stimulation
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