Renal Prostaglandins in Human Adaptation to Modifications of Sodium Balance
In spite of the exponential growth of the literature dealing with prostaglandins in general, our knowledge of the physiological role of renal prostaglandins leaves much to be desired. Prostaglandins (PG) synthetized within the kidney exert a variety of actions: One may be to alter hemodynamics, another to facilitate renin secretion, and a third to modulate sodium and water excretion. Yet we still do not know if their role is limited to the regulation of intrarenal blood flow distribution, to the control of renin release, or to the modulation of the effect of peptide hormones such as angiotensin II and vasopressin on their respective target cells. Each of these actions have been observed, but mainly in extreme situations which deviate markedly from those to which humans are normally exposed. It appears that an intricate interplay exists between hemodynamic and hormonal adjustments of the kidney in conditions where salt and/ or water balance is compromised, which make difficult and complex any description of changes of the hormones and local factors involved in the maintainance of salt and water homeostasis. Our approach, and that of other workers in the field, has been oriented towards combining physiological and pharmacological experimental conditions in order to gain better insight into this complex subject.
KeywordsPlasma Renin Activity Sodium Excretion Prostaglandin Synthesis Sodium Retention Renin Release
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