The Effects of Vasopressin and Vasopressin Analogues upon Renal Synthesis of Prostaglandins

  • Michael J. Dunn
  • Thomas R. Beck
  • Lewis B. Kinter
  • Aviv Hassid


The interactions of vasopressin and renal prostaglandins have elicited substantial interest since the original demonstration by Orloff et al. in 1965 that prostaglandin (PG) El reduced the effect of vasopressin on water transport in the toad bladder.1 Subsequently, it has been well documented that prostaglandins, particularly of the E series, inhibit vasopressin-stimulated water reabsorption in the toad bladder2–5 and in the microperfused rabbit collecting tubule.6 This inhibitory or negative feedback effect of prostaglandins upon vasopressin-mediated water transport is undoubtedly a result of prostaglandin antagonism of vasopressin-stimulated adenylate cyclase.1,3–7 Inhibition of prostaglandin synthesis, in vivo, with indomethacin, meclofenamate, or aspirin enhances the antidiuretic effect of vasopressin in rats,8,9 dogs,10,11 and humans.8 In the aggregate, these experiments over the last 15 years strongly implicate renal prostaglandins as negative feedback modulators which alter the renal actions of vasopressin (for recent reviews see Ref. 12–15).


Diabetes Insipidus Arginine Vasopressin Urine Osmolality Nephrogenic Diabetes Insipidus PGE2 Synthesis 
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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • Michael J. Dunn
    • 1
    • 2
  • Thomas R. Beck
    • 3
  • Lewis B. Kinter
    • 4
  • Aviv Hassid
    • 1
  1. 1.Department of MedicineCase Western Reserve UniversityClevelandUSA
  2. 2.Division of NephrologyUniversity Hospitals of ClevelandClevelandUSA
  3. 3.Department of MedicineUniversity Hospitals of ClevelandClevelandUSA
  4. 4.Department of PhysiologyHarvard Medical SchoolBostonUSA

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