Reversal of Vasoconstriction in the Isolated Perfused Rat Kidney by Picogram Amounts of PGE2
The isolated Krebs perfused kidney of the rat has previously been suggested to be unique among other species in that prostaglandin E2 (PGE2) and prostaglandin A2 (PGA2) produce vasoconstriction.1 This finding has recently found support from in vivo experiments.2 These data are in sharp contrast to the well-known systemic vasodilator effects of these compounds and suggest that possibly the renal vascular bed has some intrinsic property which makes it constrict in response to prostaglandins.3–6
KeywordsPerfusion Pressure Vasodilator Effect Renal Vascular Resistance Renal Vasculature Arterial Cannula
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