Reversal of Vasoconstriction in the Isolated Perfused Rat Kidney by Picogram Amounts of PGE2

  • C. R. Pace-Asciak
  • A. Rosenthal


The isolated Krebs perfused kidney of the rat has previously been suggested to be unique among other species in that prostaglandin E2 (PGE2) and prostaglandin A2 (PGA2) produce vasoconstriction.1 This finding has recently found support from in vivo experiments.2 These data are in sharp contrast to the well-known systemic vasodilator effects of these compounds and suggest that possibly the renal vascular bed has some intrinsic property which makes it constrict in response to prostaglandins.3–6


Perfusion Pressure Vasodilator Effect Renal Vascular Resistance Renal Vasculature Arterial Cannula 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Malik KU, McGiff JC: Modulation by prostaglandins of adrenergic transmission in the isolated perfused rabbit and rat kidney. Circ Res 36: 599–609, 1975.PubMedGoogle Scholar
  2. 2.
    Gerber JG, Nies AS: The hemodynamic effects of prostaglandins in the rat. Circ Res 44: 406–410, 1979.PubMedGoogle Scholar
  3. 3.
    Bergstrom S, Carlson LA, Eklund LG, et al: Cardiovascular and metabolic responses to infusions of prostaglandin E1 in man. Acta Physiol Scand 64: 332–339, 1965.PubMedCrossRefGoogle Scholar
  4. 4.
    Malik KU, McGiff JC: Cardiovascular actions of prostaglandins, in Karim SMM (ed): Prostaglandins: Physiological, Pharmacological and Pathological Aspects, Advances in Prostaglandin Research. Lancaster: MTP Press, 1976, pp 103–200.Google Scholar
  5. 5.
    Armstrong JM, Blackwell GJ, Flower RJ, et al: Genetic hypertension in rats is accompanied by a defect in renal prostaglandin catabolism. Nature 260: 582–586, 1976.PubMedCrossRefGoogle Scholar
  6. 6.
    Pace-Asciak CR, Carrara MC, Nicolaou KC: Prostaglandin I2 has more potent hypotensive properties than prostaglandin E2 in the normal and spontaneously hypertensive rat. Prostaglandins 15: 999–1003, 1978.CrossRefGoogle Scholar
  7. 7.
    Rosenthal AR, Pace-Asciak CR: Prostaglandin E2 potently opposes the vasopressin-induced constriction in the isolated perfused rat kidney. Fed Proc 39: 3832, 1980.Google Scholar
  8. 8.
    Pace-Asciak CR, Rosenthal AR: Constriction of the isolated intact rat kidney by vasopressin is strongly opposed by POE, and PGE2. Prog Lipid Res 20: 605–608, 1982.CrossRefGoogle Scholar
  9. 9.
    Nishiitsutsuji-Uwo JM, Ross BD, Krebs HA: Metabolic activities of the isolated perfused rat kidney. Biochem J 103: 852–862, 1967.PubMedGoogle Scholar
  10. 10.
    Staszewska-Barczak J, Vane JR: The role of prostaglandin in the local control of circulation. Clin Exp Pharmacol Physiol Suppl 2: 71–78, 1975.Google Scholar

Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • C. R. Pace-Asciak
    • 1
  • A. Rosenthal
    • 1
  1. 1.Research InstituteHospital for Sick ChildrenTorontoCanada

Personalised recommendations