Biosynthesis and Metabolism of Prostaglandins in Human Kidney in Vitro
The importance of prostaglandins (PGs) in renal physiology is becoming increasingly appreciated.1 The vasoactivity of renal PGs and their interactions with the rennin-angiotensin system seem to be particularly well established. Specific renal effects of PGE2, PGI2, and thromboxane (TX) A2 have been proposed, whereas PGF2α appears to be largely biologically inert.
KeywordsCytosolic Fraction Human Kidney Microsomal Protein Rabbit Kidney Cortical Tubule
Unable to display preview. Download preview PDF.
- 1.Dunn MJ: Renal prostaglandins, in Klahr S, Massry SG (eds): Contemporary Nephrology. New York, Plenum, 1981, vol 1, p 4.Google Scholar
- 3.Crowshaw K, McGiff JC: Prostaglandins in the kidney: A correlative study of their biochemistry and renal function, in Sambhi MP (ed): Mechanisms of Hypertension. New York, American Elsevier, 1973, p 254.Google Scholar
- 7.Morrison AR, Nishikawa K, Needleman P: Thromboxane A2 biosynthesis in the ureter obstructed isolated perfused kidney of the rabbit. J Pharmaco! Exp Ther 205: 1–8, 1978.Google Scholar
- 15.Wong PYK, Lee WH, Chao PHW, et al: Metabolism of prostacyclin by 9-hydroxyprostaglandin dehydrogenase in human platelets: Formation of a potent inhibitor of platelet aggregation and enzyme purification. J Bio! Chem 255: 9021–9024, 1980.Google Scholar
- 18.Hassid A, Dunn MJ: Microsomal prostaglandin biosynthesis of human kidney. JBiol Chem 255: 2472–2475, 1980.Google Scholar