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Ethanol and Blood Lipids in Man

  • P. Avogaro
  • G. Bittolo-Bon
  • F. Belussi
  • G. Cazzolato
Conference paper
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 51)

Abstract

Ethanol is a powerful inducer of hyperlipemia in both animal and man. This effect is an interesting part of the confused and far from clear correlation between alcohol and cardiovascular disease. This review will refer some of the more relevant aspects of this relationship stressing both the data pointing to alcohol as a protective factor for the myocardium and the data indicating alcohol as a source of myocardial damage.

Keywords

Plasma Lipid Blood Lipid Lipoprotein Lipase Ethanol Intake Aortic Atherosclerosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Nikkila, E.A., and Ollila, O., Effect of alcohol ingestion on experimental chicken atherosclerosis, Circ.Res. 7: 588–594 (1959).PubMedGoogle Scholar
  2. 2.
    Vasdev, S.C., Charravarti, R.N., Subrahlmanyam, D., and Wahi, P.L. Effect of chronic alcohol administration on blood and tissue lipids and hystopathology of the heart in the Rhesus monkeys, Indian J.Med.Res. 63: 420–425 (1973).Google Scholar
  3. 3.
    Nichols, C.W., Siperstein, M.D., Gaffey, W., Lindsay, S., and Chaikoff, I.L., Does the ingestion of alcohol influence the development of atherosclerosis in fowls?, J.Exp.Med. 103: 465–475 (1956).PubMedCrossRefGoogle Scholar
  4. 4.
    Gottlieb, L.S., Broitman, S.A., Vitale, J.J., and Zamcheck, N., The influence of alcohol and dietary magnesium upon hypercholesterolemia and atherogenesis in the rat, J.Lab.Clin.Med. 53: 433–441 (1959).PubMedGoogle Scholar
  5. 5.
    Goto, Y., Hikuchi, H., Abe, K., Nagawashi, Y., Ohira, S., and Kudo H., The effect of ethanol on the onset of experimental athero-sclerosis, Tohoku J.Exp.Med. 114: 35–43 (1974).PubMedCrossRefGoogle Scholar
  6. 6.
    Viel, B.S., Danson, S., Slacedo, D., Dojas, P., Varela, N., and Alessandri, R., Alcoholism and socioeconomic status, hepatic damage and atherosclerosis, Arch.Intern.Med. 117: 84–91 (1966).PubMedCrossRefGoogle Scholar
  7. 7.
    Spain, D.M., and Bradess, V.A., Sudden death from coronary athero-sclerosis, Arch.Intern.Med. 100: 228–231 (1957).CrossRefGoogle Scholar
  8. 10.
    Pell, S.A., and D’Alonzo, C.A., A five-years mortality study of alcoholics, J.Occup.Med. 15: 120–125 (1973).PubMedGoogle Scholar
  9. 11.
    Myrhed, M., Alcohol consumption in relation to factors associated with ischemic heart disease, Acta Med.Scand. 196, suppl. 567: 8–93 (1974).Google Scholar
  10. 12.
    Sirtori, C.R., Biasi, G., Vercellio, G., Agradi, E., and Malan, E. Diet lipids and lipoproteins in patients with peripheral vascular disease, Am.J.Med.Sci. 268: 325–332 (1974).PubMedCrossRefGoogle Scholar
  11. 13.
    Castelli, W.P., Gordon, T., and Hjortland, M.C., Alcohol and blood lipids; the cooperative phenotyping study, Lancet ii: 53–157 (1977).Google Scholar
  12. 14.
    Miller, C.J., and Miller, M.E., Plasma high-density-lipoprotein concentration and development of ischemic heart disease, Lancet i: 16–19 (1975).Google Scholar
  13. 15.
    Barboriak, J.J., Anderson, A.J., and Hoffmann, R.G., Interrelationship between coronary artery occlusion, high-density-lipoprotein cholesterol, and alcohol intake, J.Lab.Clin.Med. 94: 348–353 (1979).PubMedGoogle Scholar
  14. 17.
    Hillbom, M., and Kaste, M., Does ethanol intoxication promote brain infarction in young adults?, Lancet ii: 1181–1183 (1978).Google Scholar
  15. 18.
    Avogaro, P., and Cazzolato, G., Changes in the composition and Physico-chemical characteristics of serum lipoproteins during ethanol-induced lipemia in alcoholic subjects, Metabolism 24: 1231–1242 (19 75).Google Scholar
  16. 19.
    Nestel, P.J., and Hirsch, E.Z., Clinical and experimental mecha-nism of alcohol-induced hypertriglyceridemia, J.Lab.Clin.Med. 66: 357–365 (1965).PubMedGoogle Scholar
  17. 20.
    Baraona, E., and Lieber, C.S., Effects of ethanol on lipid metabolism, J.Lipid Res. 20: 289–315 (1979).PubMedGoogle Scholar
  18. 21.
    Johanson, B.G., and Laurell, C.B., Disorders of serum a-lipopro- teins after alcoholic intoxication, Scand.J.Clin.Lab.Invest. 23: 231–233 (1979).CrossRefGoogle Scholar
  19. 22.
    Avogaro, P., Cazzolato, G., Bittolo Bon, G., and Belussi, F., Ethanol lipemia. A doubtful risk factor. In: Atherosclerosis IV, G. Schettler, Y. Goto, Y. Hata, and G. Klose, Springer-Verlag, Berlin, pp. 658–664 (1977).Google Scholar
  20. 23.
    Avogaro, P., Bittolo Bon, G., Cazzolato, G., and Belussi, F., Lipoproteins and apolipoproteins in chronic alcoholics and in alcoholic liver cirrhosis, Recent Adv. in Clinical Nutr. i, John Libbey and Co., London (in press).Google Scholar
  21. 24.
    Nilsson-Ehle, P., Alcohol induced alterations in lipoproteins lipase activity and plasma lipoproteins. In: Metabolic effects of alcohol, P. Avogaro, C.R. Sirtori, and E. Tremoli, Elsevier/North Holland, pp. 175–186 (1979).Google Scholar
  22. 25.
    Walton, K.W., Hitchens, J., Magnani, H.N., and Khan M., A study of methods of identification and estimation of Lp(a) lipoprotein and of its significance in health, hyperlipidemia and atherosclerosis, Atherosclerosis 20: 223–234 (1974).CrossRefGoogle Scholar
  23. 26.
    Kostner, G.M., Avogaro, P., Cazzolato, G., Marth, E., Bittolo Bon, G., and Quinci, G.B., Lipoprotein Lp(a) and the risk for myocardial infarction, Atherosclerosis (in press)a.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • P. Avogaro
    • 1
  • G. Bittolo-Bon
    • 1
  • F. Belussi
    • 1
  • G. Cazzolato
    • 1
  1. 1.Sub-project Atherosclerosis, National Council for ResearchRegional General HospitalVeniceItaly

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