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Platelet and Vascular Prostaglandins in Uraemia, Thrombotic Microangiopathy and Pre-Eclampsia

  • G. de Gaetano
  • M. Livio
  • M. B. Donati
  • G. Remuzzi
Conference paper
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 51)

Abstract

The metabolism of arachidonic acid in platelets and vascular cells is often altered in clinical conditions associated with haemorrhagic or thromboembolic complications.

Keywords

Thrombotic Thrombocytopenic Purpura Thrombotic Microangiopathy Haemolytic Uraemic Syndrome Uraemic Patient Plasma Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bodzenta, A., Thomson, J. M., and Poller, L., 1980, Prostacyclin activity in amniotic fluid in pre-eclampsia, Lancet ii: 650.Google Scholar
  2. Budd, G. T., Bukowski, R. M., Lucas, F. V., Cato, A. E., and Cocchetto, D. M., 1980, Prostacyclin therapy of thrombotic thrombocytopenic purpura, Lancet ii: 915.Google Scholar
  3. Bussolino, F., Benedetto, C., Massobrio, M., and Camussi, G., 1980, Maternal vascular prostacyclin activity in pre-eclampsia, Lancet ii: 702.Google Scholar
  4. Byrnes, J. J., and Khurana, M., 1977, Treatment of thrombotic thrombocytopenic purpura with plasma, N. Eng. J. Med. 29 7: 1386.CrossRefGoogle Scholar
  5. Carreras, L. D., Defreyn, G., Machin, S. J., and Vermylen, J., 1980, Inhibition of prostacyclin release from rat aorta by IgG from a patient with lupus anticoagulant and recurrent thrombosis, In: Abstracts Sixth International Congress on Thrombosis, Montecarlo, October 1980, n. 187.Google Scholar
  6. Crandon, A. J., and Isherwood, D. M., 1979, Effect of aspirin on incidence of pre-eclampsia, Lancet i: 1356.Google Scholar
  7. Defreyn, G., Vergara Dauden, M., Machin, S. J., and Vermylen, J., 1980, A plasma factor in uraemia which stimulates prostacyclin release from cultured endothelial cells, Thromb. Res. 19:695.PubMedCrossRefGoogle Scholar
  8. Donati, M. B., Misiani, R., Marchesi, D., Livio, M., Mecca, G., Remuzzi G., and de Gaetano, G., 1980, Hemolytic-uremic syndrome, prostaglandins, and plasma factors, In: Hemostasis, Prostaglandins and Renal Disease, G. Remuzzi, G. Mecca, and G. de Gaetano, eds.,pp. 283–290, Raven Press, New York.Google Scholar
  9. Downing,. I., Shepherd, G. L., and Lewis, P. J., 1980, Reduced prostacyclin production in pre-eclampsia, Lancet ii: 1374Google Scholar
  10. Ferris, T. F., 1978, Postpartum renal insufficiency, Kidney Int. 14: 383.PubMedCrossRefGoogle Scholar
  11. Hensby, C. N., Lewis, P. J., Hilgard, P., Mufti, G. J., Hows, J., and Webster, J., 1979, Prostacyclin deficiency in thrombotic thrombocytopenic purpura, Lancet ii: 748.Google Scholar
  12. Leithner, C., Winter, M., Silberbauer, K., Wagner, O., Pinggera, W., and Sinzinger, H., 1978, Enhanced prostacyclin availability of blood vessels in uraemic humans and rats, In: Dialysis, Transplantation, Nephrology, B. H. B. Robinson and J. B. Hawkins, eds., pp. 418–422, Pitman Medical, Tunbridge Wells, Kent, U.K.Google Scholar
  13. Lewis, P. J., Boylan, P., Friedman, L. A., Hensby, C. N., and Drowning, I., 1980, Prostacyclin in pregnancy, Br. Med. J. 280: 1581.PubMedCrossRefGoogle Scholar
  14. Machin, S. J., Defreyn, G., Chamone, D. A. F., and Vermylen, J., 1980, Plasma 6-keto-PGF1α levels after plasma exchange in thrombotic thrombocytopenic purpura, Lancet i: 661.Google Scholar
  15. MacIntyre, D. E., Pearson, J. D., and Gordon, J. L., 1978, Localisation and stimulation of prostacyclin production in vascular cells, Nature 271: 549.PubMedCrossRefGoogle Scholar
  16. Okuma, M., Takayama, H., and Uchino, H., 1980, Generation of prostacyclin-like substance and lipid peroxidation in vitamin Edeficient rats, Prostaglandins 19: 527.PubMedCrossRefGoogle Scholar
  17. Rankin, J. H. G., Berssenbrugge, A., Anderson, D., and Phernetton, T., 1979, Ovine placental vascular response to indomethacin, Am. J. Physiol. 236: H61–H64.Google Scholar
  18. Remuzzi, G., Cavenaghi, A. E., Mecca, G., Donati, M. B., and de Gaetano, G., 1977, Prostacyclin-like activity and bleeding in renal failure, Lancet ii: 1195.Google Scholar
  19. Remuzzi, G., Marchesi, D., Livio, M., Schieppati, A., Mecca G., Donati, M. B., and de Gaetano, G., 1980a, Prostaglandins, plasma factors and hemostasis in uraemia, In: Hemostasis, Prostaglandins and Renal Disease, G. Remuzzi, G. Mecca, and G. de Gaetano, eds. pp. 273–281, Raven Press, New York.Google Scholar
  20. Remuzzi, G., Marchesi, D., Zoja, C., Muratore, D., Mecca, G., Misiani, R., Rossi, E., Barbato, M., Capetta, P., Donati, M. B., and de Gaetano, G., 1980b, Reduced umbilical and placental vascular prostacyclin in severe pre-eclampsia, Prostaglandins 20: 105PubMedCrossRefGoogle Scholar
  21. Remuzzi, G., Mecca, G., Livio, M., de Gaetano, G., Donati, M. B. Pearson, J. D., and Gordon, J. L., 1980, Prostacyclin generation by cultured endothelial cells in haemolytic uraemic syndrome, Lancet i: 656.Google Scholar
  22. Remuzzi, G., Misiani, R., Marchesi, D., Livio, M., Mecca, G., de Gaetano, G., and Donati, M. B., 1978, Haemolytic-uraemic syndrome: Deficiency of plasma factor(s) regulating prost-acyclin activity?, Lancet ii: 871.Google Scholar
  23. Remuzzi, G., Misiani, R., Muratore, D., Marchesi, D., Livio, M., Schieppati, A., Mecca, G., de Gaetano, G., and Donati, M. B., 1979, Prostacyclin and human foetal circulation, Prostaglandins 18: 341.PubMedCrossRefGoogle Scholar
  24. Remuzzi, G., Zoja, C., Marchesi, D., Schieppati, A., Mecca, G., Misiani, R., Donati, M. B., and de Gaetano, G., 1981, Plasmatic regualtion of vascular prostacyclin in pregnancy, Br. Med. J.Google Scholar
  25. Saeed, S. A., McDonald-Gibson, W. J., Cuthbert, J., Copas, J. L., Schneider C., Gardiner, P. J., Butt, N. M., and Collier, H. O. J. 1977, Endogenous inhibitor of prostaglandin synthetase, Nature 270: 32.PubMedCrossRefGoogle Scholar
  26. Stamler, F. W., 1959, Fatal eclamptic disease of pregnant rats fed anti-vitamin E stress diet, Am. J. Pathol. 35: 1207.PubMedGoogle Scholar
  27. Webster, J., Rees, A. J., Lewis, P. J., and Hensby, C. N., 1980, Prostacyclin deficiency in haemolytic-uraemic syndrome, Br. Med. J. 281: 271.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • G. de Gaetano
    • 1
    • 2
  • M. Livio
    • 1
    • 2
  • M. B. Donati
    • 1
    • 2
  • G. Remuzzi
  1. 1.Istituto di Ricerche Farmacologiche “Mario Negri”MilanItaly
  2. 2.Division of Nephrology and DialysisOspedali RiunitiBergamoItaly

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