Endogenous Agents in Platelet Thrombosis

  • G. V. R. Born
  • M. A. A. Kratzer
Conference paper
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 51)


Any hypothesis for arterial thrombosis must be able to account for the following facts: (1) thrombi do not form in normal arteries; (2) thrombi form in atherosclerotic arteries; (3) arterial thrombi consist initially of aggregated platelets; (4) atherosclerosis increases slowly, whereas thrombosis occurs rapidly and is individually unpredictable. Therefore, atherosclerotic arteries must be subject to sudden, unpredictable events capable of initiating platelets aggregation; (5) most occlusive thrombi are associated with fissures in underlying atheromatous placques.


Arterial Thrombosis Aggregate Platelet Boundary Layer Separation Mural Thrombus Occlusive Thrombus 


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • G. V. R. Born
    • 1
  • M. A. A. Kratzer
    • 1
  1. 1.Department of PharmacologyUniversity of London King’s CollegeLondonUK

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