Interactions Between Lipoproteins and Glycosaminoglycans
Heparin and other glycosaminoglycans (GAG) are widely distributed in animal species and humans and may play a relevant role in a number of physiological processes. Heparin and GAG, when intravenously injected, induce a deep, transient modification of the blood clotting system, as well as of the plasma lipids disposition. The effect on the coagulation system is mainly due to the interaction of Heparin with antithrombin III, while that on plasma lipoproteins is usually related to the release of lipoprotein lipases from their binding sites. Plasma lipoproteins, however, interact in vivo and in vitro with GAG and Heparin (1). We shall briefly discuss here the lipoprotein-GAG interactions as a relevant phenomenon in the lipoprotein catabolism as well as a tool in the separation of lipoprotein subclasses.
KeywordsHigh Density Lipoprotein Unbind Fraction Lecithin Cholesterol Acyl Transferase Lipoprotein Subclass Blood Clotting System
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