Advertisement

Effect of Parathyroid Hormone on the Isolated Papillary Muscle of the Rat Heart

  • Kiyoshi Kurokawa
  • Yoichi Katoh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 151)

Abstract

It has been well accepted that the bone and the kidney are the principal organs of parathyroid hormone (PTH) action. Several lines of evidence obtained during the last decade suggest that PTH directly acts on organs other than the bone and kidney; these include the brain, liver and blood cells (1–5).

Keywords

Parathyroid Hormone Papillary Muscle Coronary Blood Flow Myocardial Contractility Inotropic Action 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Arieff, A.I., and S.G. Massry, Calcium metabolism of brain in acute renal failure. J. Clin. Invest. 53:387–392 (1974).PubMedCrossRefGoogle Scholar
  2. 2.
    Goldstein, D.A., L.A. Chui, and S.G. Massry, Effect of parathyroid hormone and uremia on peripheral nerve calcium and motor nerve conduction velocity. J. Clin. Invest. 62:88–93 (1978).PubMedCrossRefGoogle Scholar
  3. 3.
    Maxley, M.A., N.H. Beel, S.R. Wazle, et al. Parathyroid hormone stimulation of glucose and urea production in isolated liver cells. Am. J. Physiol. 227:1058–1061 (1964).Google Scholar
  4. 4.
    Hruska, K.A., J. Blondin, R. Bass, et al, Effect of intact parathyroid hormone on hepatic glucose release in the dog. J. Clin. Invest. 64:1016–1023 (1979).PubMedCrossRefGoogle Scholar
  5. 5.
    Meytes, D., E. Bogin, A. Ma, et al, Effect of parathyroid hormone on erythropoiesis. J. Clin. Invest. 67:1263–1269 (1981).PubMedCrossRefGoogle Scholar
  6. 6.
    Pang, P.K.T., T.E. Tanner, Jr., J.A. Yee, et al, Hypotensive action of parathyroid hormone preparations on rats and dogs. Proc. Natl. Acad. Sci., USA, 77:675–678 (1980).PubMedCrossRefGoogle Scholar
  7. 7.
    Crass, M.F., III., and P.K.T. Pang, Parathyroid hormone: A coronary artery vasodilator. Science 207:1087–1089 (1980).PubMedCrossRefGoogle Scholar
  8. 8.
    Bogin, E., S.G. Massry, and I. Harary, Effect of parathyroid hormone on rat heart cells. J. Clin. Invest. 67:1215–1227 (1981).PubMedCrossRefGoogle Scholar
  9. 9.
    Katoh, Y., K.L. Klein, R.A. Kaplan, et al, Parathyroid hormone has a positive inotropic action in the rat. Endocrinology 109:2252–2254 (1982).CrossRefGoogle Scholar
  10. 10.
    Sonnenblick, E.H., Force-velocity relations in mammalian heart muscle. Am. J. Physiol. 202:931–939 (1961).Google Scholar
  11. 11.
    Sanborn, W.G., and B.L. Stremel, Ferrocyanide protection against uncoupling of excitation and contraction by maganese in rabbit ventricular myocardium. Circu. Res. 43:178–188 (1978).Google Scholar
  12. 12.
    Wennmalm, A., Maintenance of noradrenaline synthesis in rats after reserpine treatment. Acta Physiol. Scand. 73:523–526 (1968).Google Scholar
  13. 13.
    Levey, G.S., and S.E. Epstein, Activation of adenyl cyclase by glucagon in cat and human heart. Circu. Res. 24:151–156 (1969).Google Scholar
  14. 14.
    Rasmussen, H., P. Bordier, K. Kurokawa, et al, Hormonal control of skeletal and mineral homeostasis. Am. J. Med. 56:751–758 (1974).PubMedCrossRefGoogle Scholar
  15. 15.
    Fleckenstein, A., Specific inhibitors and promoters of calcium action in the excitation-contraction coupling of heart muscle and their role in the prevention or production of myocardial lesions, in: “Caclium and the Heart,” P. Harris and I.H. Opie, ed., Academic Press, London and New York (1971).Google Scholar
  16. 16.
    Kurokawa, K., T. Ohno, and H. Rasmussen, Ionic control of renal gluconeogenesis. II. The effects of Ca++ and H+ upon the response to parathyroid hormone and cyclic AMP. Biochim. Biophys. Acta. 313:32–41 (1973).PubMedCrossRefGoogle Scholar
  17. 17.
    Goltzman, D., B. Henderson, and N. Loveridge, Cytochemical bioassay of parathyroid hormone. J. Clin. Invest. 65: 1309–1317 (1980).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Kiyoshi Kurokawa
    • 1
  • Yoichi Katoh
    • 1
  1. 1.Medical and Research Services, Veterans Administration, Wadsworth Medical Center and the Department of MedicineUCLA School of MedicineLos AngelesUSA

Personalised recommendations