Role of PTH, Metabolic Factors and Other Hormones in Extra-Renal Acid Buffering
The maintenance of normal acid-base homeostasis is dependent on the renal excretion of acid (as well as the reclamation of bicarbonate) and extra-renal buffering of acid which originates either from normal metabolism or from exogenous sources. The factors influencing renal acid excretion have been well studied. Those events which control the buffering of an acid load are less completely understood (1). Since it is believed that the skeleton is a major source of buffer, events which influence the metabolism of bone may have a profound effect on extra-renal buffering. Fraley and Adler, as well as our own group, have demonstrated that parathyroid hormone (PTH) plays a major role in the buffering of acute acid loads (2,3). More recently we have had the opportunity to study the effects of a number of other hormonal and metabolic factors which influence extra-renal buffering (4). This paper reviews our work; it examines the effect of PTH and other metabolic regulators on extra-renal buffering.
KeywordsParathyroid Hormone Chronic Renal Failure Carbonic Anhydrase Salmon Calcitonin Acid Load
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