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Vascular Effects of Parathyroid Hormone (PTH)

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Book cover Regulation of Phosphate and Mineral Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 151))

Abstract

The effects of PTH on blood pressure (BP) are complex and many observations in literature on acute or chronic PTH excess or withdrawal are apparently contradictory. The present report reviews the information in literature and tries to provide a conceptual framework for the different vascular effects of PTH.

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References

  1. Hellstrom, J., Brike, G., Edvall, C.A., 1958, Hypertension in hyperparathyroidism, Br.J.Urol., 30:13

    Article  PubMed  CAS  Google Scholar 

  2. Lemann, J., Donatelli, A.A., 1964, Calcium intoxication due to primary hyperparathyroidism, Ann. Int.Med. 60: 447

    Google Scholar 

  3. Pyrah, L.N., Hodgkinson, A., Anderson, C.K., 1966, Primary hyperparathyroidism. Critical review, Brit.J.Surg., 53: 245

    Google Scholar 

  4. Madhavan, T., Frame, B., Bloch, M.A., 1970, Influence of surgical correction of primary hyperparathyroidism on associated hypertension, Arch.Surg. 100: 212

    Article  PubMed  CAS  Google Scholar 

  5. Rosenthal, F.D., Roy, S., 1972, Hypertension and hyperparathyroidism, Brit.Med.J., 4: 396

    Article  PubMed  CAS  Google Scholar 

  6. Johansson, H., Thoren, L., Werner, I., 1972, Hyperparathyroidism. Clinical experiences from 208 cases, Uppsala J.Med.Sci., 77: 41

    CAS  Google Scholar 

  7. Romanus, R., Heimann, P., Nilsson, O., Hansson, G., 1973, Surgical treatment of hyperparathyroidism, Progr.Surg., 12: 22

    CAS  Google Scholar 

  8. Genant, M.K., Heck, L.L., Lanzl, L.M., Rossmann, K. van der Horst, J., Paloyan, E., 1973, Primary hyperparathyroidism, Radiology 109: 513

    CAS  Google Scholar 

  9. Mallette, L.E., Bilezikian, J.P., Heath, D.A., Aurfach, G.D., 1974, Primary hyperparathyroidism: clinical and biochemical features, Medicine, 53: 127

    Article  PubMed  CAS  Google Scholar 

  10. Ohlsson, L., 1975, Primär hyperparathyroidism. En Studie av 160 patienter med särskild hänsyn till njurfunktion och stensjukdom efter operation. Academic thesis. Uno Lundgrens. Trykeri AB, Gothenburg

    Google Scholar 

  11. Christensson, T., Hellström, K., Wengle, B., 1977, Blood pressure in subjects with hypercalcemia and primary hyperparathyroidism detected in a health screening programm, Eur. J. Clin. Invest, 7: 109

    Google Scholar 

  12. Weidmann, P., Massry, S.G., Coburn, J.W., Maxwell, M.M., Atleson, J., Kleeman, C.R., 1972, Blood pressure effects of acute hypercalcemia, Ann.Int. Med. 76: 741

    Google Scholar 

  13. Marone, C., Beretta-Piccoli, C., Weidmann, P., 1980, Acute hypercalcemic hypertension in man: Role of hemodynamics, catecholamines and renin, Kidney Int., 20: 92

    Google Scholar 

  14. Frohlich, E.D., Scott, J.B., Haddy, F.J., 1962, Effects of cations on resistance and responsiveness of renal and forelimb vascular beds., Am.J. Physiol., 203: 582

    Google Scholar 

  15. Bartter, F.C., 1954, The parathyroids, Ann.Rev. Physiol. 16: 429

    Google Scholar 

  16. Charbon, G.A., 1964, Parathormone a relative vasodilator, in: “Parathyroid Hormoneand Thyreocalcitonin”, R.V. Talmage, ed., Excerpta Medica, 475

    Google Scholar 

  17. Charbon, G.A., Hulstaert, P.F., 1974, Augmentation of arterial hepatic and renal flow by extracted and synthetic parathyroid hormone/Endocrinology, 95: 621

    CAS  Google Scholar 

  18. Hallberg, D., Werner, S., 1977, Circulatory and lipolytic effects of parathyroid hormone, Horm. Metab. Res. 9: 424

    Google Scholar 

  19. Lindner, A., Tremann, J.A., Plantier, J., Chapman, W., Forrey, A.W., Haines, G., Palmieri, G.M., 1978, Effects of parathyroid hormone on the renal circulation and renin secretion in unanesthesized dogs, MEM 1: 155

    CAS  Google Scholar 

  20. Smith, M.J., Mouw, D.R., Vander, A.J., 1979, Effect of parathyroid hormone on plasma renin activity and sodium excretion, Am.J.Physiol. 236 (3): 311

    Google Scholar 

  21. Crass, M.F., Pang, P.K.T., 1980, Parathyroid hormone: a coronary artery vasodilator, Science, 207: 1087

    Article  PubMed  CAS  Google Scholar 

  22. Hashimoto, K., Nakagawa, Y., Shibaya, T., Satob, M., Ushijima, T., Imai, S., 1981, Effects of parathyroid hormone and related polypeptides on the heart and coronary circulation of dogs, J.Cardiovasc. Pharm. 3: 668

    Google Scholar 

  23. Boellins, J.N., Mazurkiewicz, M., Mazur, P.E., Müller, W.J., 1976, Changes in blood flow to bones during the hypocalcemic and hypercalcemic phases of the response to parathyroid hormone, Endocrinology 98: 403

    Article  Google Scholar 

  24. Driessens, M., Vanhoutte, P.M., 1981, Effect of calcitonin, hydrocortisone, and parathyroid hormone on canine bone blood vessels, Am.J.Physiol., 241: 91

    Google Scholar 

  25. Pang, P.K.T., Yang, M., Oguro, C., Phillips, J.G., 1980, Hypotensive actions of parathyroid hormone preparations in vertebrates, Gen.Comp.Endoc. 41: 135

    Article  CAS  Google Scholar 

  26. Pang, P.K.T., Tenner, Th.E., Yee, J.A., Yang, M., Jansson, H.F., 1980, Hypotensive actions of parathyroid hormone preparations on rats and dogs, Proc. Natl.Acad.Sci.USA 77: 675

    Google Scholar 

  27. Pang, P.K.T., Yang, M.C., Tenner, Th., Chang, J.K., Shimiza, M., 1981, Hypotensive action of synthetic fragments of parathyroid hormone, J.Pharmacol. Exp.Ther. 216: 567

    Google Scholar 

  28. Anderson, S., McCarron, D.A., 1981, Enhanced sensitivity to parathyroid hormone administration in the SH rat, 4th Intern. Symp. Rats Spont. Hypertension, Heidelberg, Sept. 1981, a 58

    Google Scholar 

  29. Rascher, W., Rambausek, M., Kreusser, W., Ritz, E., 1982, Are prostaglandins and the sodium potassium pump involved in the vasodilations induced by parathyroid hormone? 9th Scient. Meeting Int. Soc. Hypertension, Mexico, Feb. 1982, abstr.

    Google Scholar 

  30. Kreye, V.A.W., Baron, G.D., Lüth, J.B., Schmidt-Gayk, H., 1975, Mode of action of sodium nitropruside on vascular smooth muscle, Naunyn-Schmiedebergs Arch.Pharmacol., 288: 381

    Article  PubMed  CAS  Google Scholar 

  31. Rascher, W., Schömig, A., Kreye, V., Ritz, E., Diminished vascular response to norepinephrine in experimental uremia, Kidney Int. (in press)

    Google Scholar 

  32. Adelstein, R., Conti, M.A., Hathaway, D.R., 1978, Phosphorylation of smooth muscle myosin light chain kinase by the catalytic subunit of adenosine 3′5′-monophosphate-dependent protein kinase, J.Biol.Chem., 253: 8347

    PubMed  CAS  Google Scholar 

  33. Rüegg, J.C., Sparrow, M.P., Mrwa, U., 1981, Cyclic AMP mediated relaxation of chemically skinned fibres of smooth muscle, Pflügers Arch., 390: 198

    Article  PubMed  Google Scholar 

  34. Namm, D.L., Leader, J.P., 1976, Occurence and function of cyclic nucleotides in blood vessels, Blood Vessels 13: 24

    PubMed  CAS  Google Scholar 

  35. Scheid, C.R., Honeyman, T.W., Fay, F.S., 1979, Mechanism of β-adrenergic relaxation of smooth muscle, Nature 277: 32

    Article  PubMed  CAS  Google Scholar 

  36. Cheung, W.Y., 1980, Calmodulin plays a pivotal role in cellular regulation, Science 207: 19

    Article  PubMed  CAS  Google Scholar 

  37. Oelz, O., Knapp, M.R., Robert, L.J., Oelz, R., Sweetman, B.J., Oates, J.A., Reed, W.P., 1978, Calcium-dependent stimulation of thromboxine and prostaglandin biosynthesis by ionophores, Adv. Prostaglandin Thromboxane Res. 3: 147

    Google Scholar 

  38. Berthelot, A., Gairard, A., 1980, Parathyroid hormone and deoxycorticosterone acetate induced hypertension in the rat, Clin. Science, 58: 365

    Google Scholar 

  39. Berthelot, A., Gairard, A., 1978, Effect of parathyroidectomy on cardiovascular reactivity in rats with mineralocorticoid-induced hypertension, Br.J. Pharmac, 62: 199

    Google Scholar 

  40. Bertholet, A., Gairard, A., Goyault, M., Pernot, F., 1980, Relation between calcium and cardiovascular reactivity in mineralocorticoid-induced hypertension in the rat, Br.J.Pharmac., 70: 301

    Google Scholar 

  41. Ayachi, S., 1979, Increased dietary calcium lowers blood pressure in the spontaneously hypertensive rat, Metabolism, 28;12: 1234

    Article  PubMed  CAS  Google Scholar 

  42. Ganten, D., Unger, Th., Simon, W., Schaz, K., Schölkens, B., Mann, J., Speck, G., Lang, R., Rascher, W., 1981, Contrai peptidergic stimulation: Focus on cardiovascular actions of angiotensin and opioid peptides, in: “Perspectives in Cardiovascular Research”, A.M. Katz, ed., Raven Press

    Google Scholar 

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Author information

Authors and Affiliations

  1. Dpt. Internal Medicine, Pharmacology, Physiology and Pediatrics, Ruperto-Carola-University, Heidelberg, Germany (FRG)

    M. Rambausek, E. Ritz, W. Rascher, W. Kreusser, J. F. E. Mann, V. A. W. Kreye & O. Mehls

Authors
  1. M. Rambausek
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  2. E. Ritz
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  3. W. Rascher
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  4. W. Kreusser
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  5. J. F. E. Mann
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  6. V. A. W. Kreye
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  7. O. Mehls
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Editor information

Editors and Affiliations

  1. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

  2. State University of New York at Stony Brook, Stony Brook, New York, USA

    Joseph M. Letteri

  3. Nassau County Medical Center, East Meadow, New York, USA

    Joseph M. Letteri

  4. University of Heidelberg, Heidelberg, Federal Republic of Germany

    Eberhard Ritz

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© 1982 Plenum Press, New York

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Rambausek, M. et al. (1982). Vascular Effects of Parathyroid Hormone (PTH). In: Massry, S.G., Letteri, J.M., Ritz, E. (eds) Regulation of Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 151. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4259-5_64

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  • DOI: https://doi.org/10.1007/978-1-4684-4259-5_64

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4261-8

  • Online ISBN: 978-1-4684-4259-5

  • eBook Packages: Springer Book Archive

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