Parathyroid Hormone and the Heart

  • Shaul G. Massry
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 151)


Evidence is rapidly accumulating supporting the proposal originally made by Massry in 1977 that parathyroid hormone is a major uremic toxin (1). This hypothesis implied that PTH has a multifarious extraskeletal actions affecting the functions of many organs Several observations from our laboratory (1–12) and many of the presentations in this Workshop provide strong support for a wide extraskeletal effect of PTH.


Calcium Ionophore Heart Cell Calcium Ionophore A23187 Beat Rate Beating Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    S.G. Massry, Is parathyroid hormone a uremic toxin? Nephron, 19:125 (1977).PubMedCrossRefGoogle Scholar
  2. 2.
    A. Arieff and S.G. Massry, Calcium metabolism of brain in acute renal failure, J. Clin. Invest. 53:387 (1974).PubMedCrossRefGoogle Scholar
  3. 3.
    R. Guisado, A.I. Arieff, and S.G. Massry, Changes in the electroencephalogram in acute uremia. J. Clin. Invest. 55:138 (1975).CrossRefGoogle Scholar
  4. 4.
    D.A. Goldstein, and S.G. Massry, Effect of parathyroid hormone administration and its withdrawal on brain calcium and electroencephalogram. Min. Elect. Metab. 1:84 (1978).Google Scholar
  5. 5.
    D.A. Goldstein, L.A. Chui, and S.G. Massry, Peripheral nerve calcium and motor nerve conduction velocity in acute renal failure, J. Clin. Invest. 62:88 (1978).PubMedCrossRefGoogle Scholar
  6. 6.
    D.A. Goldstein, E.I. Feinstein, L.A. Chui, R. Pattabhiraman, and S.G. Massry, The relationship between the abnormalities in elecrroencephalogram and blood levels of PTH in dialysis patients. J. Clin. Endocrinol. Metab. 51:130, (1980).PubMedCrossRefGoogle Scholar
  7. 7.
    M. Akmal, D.A. Goldstein, S. Multani, and S.G. Massry, Parathyroid hormone (PTH) and glucose (G) intolerance test in uremia, Proc. Amer. Soc. Nephrol. 13:87A (1980).Google Scholar
  8. 8.
    E. Bogin, S.G. Massry, and I. Harary, Effect of parathyroid hormone on rat heart cells, J. Clin. Invest. 67:1215 (198l).CrossRefGoogle Scholar
  9. 9.
    D. Meytes, E. Bogin, A. Ma, P.P. Dukes, and S.G. Massry, Effect of parathyroid hormone on erythropoiesis, J. Clin.Invest. 67:1263 (1981).PubMedCrossRefGoogle Scholar
  10. 10.
    E. Bogin, S.G. Massry, J. Levi, M. Djaldeti, G. Bristol, and J. Smith, Effect of parathyroid hormone on osmotic fragility of human red blood cells, J. Clin. Invest. In press (1982).Google Scholar
  11. 11.
    E. Bogin, J. Levi, I. Harary, and S.G. Massry, Effect of parathyroid hormone on oxidative phosphorylation of heart mitochondria. Min. Elect. Metab. 7:151 (1982).Google Scholar
  12. 12.
    C.C. Doherty, P. LaBelle, N. Brautbar, D. Moyer and S.G. Massry, Effect of intact parathyroid hormone and its fragments on human polymorphonuclear leukocytes, Clin. Res. In press (1982).Google Scholar
  13. 13.
    R.C. Pabico and R.B. Freeman, Pericarditis and myocardiopathy, In Clinical Aspects of Uremia and Dialysis, S.G. Massry and A.L. Sellers, eds., Charles C. Thomas, Springfield, Illinois, pp 69–99 (1976).Google Scholar
  14. 14.
    J. Seyle, The Pleuricausal Cardiopathies, Charles C. Thomas, Springfield,. Illinois (1961).Google Scholar
  15. 15.
    D. Lehr, The role of certain electrolytes and hormones in disseminated myocardial necrosis, In Electrolyte and Cardiovascular Disease, E. Bajusz, ed., S. Karger, Basal, Switzerland, 1:248 (1966).Google Scholar
  16. 16.
    I. Harary and B. Farley, In vitro studies of heart cells in culture. I. Growth and organization, Exp. Cell Res. 29:451 (1963).PubMedCrossRefGoogle Scholar
  17. 17.
    S.G. Massry, Effect of parathyroid hormone on energy metabolism of heart, Proc. Amer. Soc. Nephrol. 14:1A (1981).Google Scholar
  18. 18.
    F. Lhoste, T. Drueke, S. Larus, and J.R. Boissier, Cardiac interaction between parathyroid hormone, β-adrenoreceptor, and verapamil in the guinea pig in vitro. Clin. Exp. Pharmacol. Physiol. 7:377 (1980).CrossRefGoogle Scholar
  19. 19.
    W.G. Nayler, Some factors involved in the maintenance and regulation of cardiac contractility, Circ. Res. 21 (Suppl III): 213 (1967).Google Scholar
  20. 20.
    T. Drueke, I. Fleury, Y. Toure, P. DeVernejoul, M. Fauchet, P. Lesourd, C. LePailleur and J. Crosnier, Effect of parathyroidectomy on left-ventricular function in haemodialysis patients, Lancet 1:112 (1980).PubMedCrossRefGoogle Scholar
  21. 21.
    N.O. Atuk, C.J. Bailey, S. Turner, M.J. Peach and F.B. Westervelt, Red blood cell catechol-o-methyl transferase, plasma catecholamines and renin in renal failure, Trans. Am. Soc. Artif. Intern. Organs 22:195 (1976).PubMedGoogle Scholar
  22. 22.
    H.M. Brecht, W. Ernst and K.M. Koch, Plasma moradrenaline levels in regular hemodialysis, Proc. Eur. Dialysis Transplant Assoc. 12:281 (1975).Google Scholar
  23. 23.
    V.M. Campese, M.S. Romoff, D. Levitan, K. Lane and S.G. Massry, Reduced end-organ response to norepinephrine in uremia: a mechanism of autonomic dysfunction, Proc. Am. Soc. Nephrol. 12:181A (1979).Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Shaul G. Massry
    • 1
  1. 1.Division of Nephrology, Department of MedicineUniversity of Southern CaliforniaLos AngelesUSA

Personalised recommendations