Interactions Between Liver and Parathyroid Hormone

  • Kevin Martin
  • Keith Hruska
  • Eduardo Slatopolsky
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 151)


In the past decade advances have been made in the understanding of the metabolism of parathyroid hormone and the interpretation of the findings of fragments of parathyroid hormone in peripheral blood. Early studies1,2 with radioimmunoassay gave different results in patients with primary hyperparathyroidism. It was thought that the radioimmunoassay for parathyroid hormone measured in blood the peptide secreted by the parathyroid glands. However, Berson and Yalow3 demonstrated that parathyroid hormone in plasma of patients was heterogeneous and differed immunologically from the hormone extracted from parathyroid glands of humans. Using different antisera they clearly demonstrated the presence of fragments of the PTH molecule with various half lives such that some fragments rapidly become undetectable after parathyroidectomy while other fragments had prolonged half lives in circulation. They also demonstrated that the half life of immun-oreactive PTH was markedly prolonged in patients with uremia. Subsequently it became apparent that intact PTH and the biologically active amino-terminal fragments have short half lives in the circulation (less than 5 minutes) while carboxy-terminal fragments have much longer half lives (30 to 40 minutes).


Thyroid Hormone Parathyroid Hormone Kupffer Cell Parathyroid Gland Intact Parathyroid Hormone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    S.A. Berson, and R.S. Yalow, Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia and bronchogenic carcinoma, Science 154:907 (1966).PubMedCrossRefGoogle Scholar
  2. 2.
    E. Reiss, and J.M. Canterbury, A radioimmunoassay for parathyroid hormone in man, Proc. Soc. Exptl. Biol. 128:501 (1968).Google Scholar
  3. 3.
    S.A. Berson, and R.S. Yalow, Immunochemical heterogeneity of parathyroid hormone in plasma, J. Clin. Endocrinol. Metab. 28:1037 (1968).PubMedCrossRefGoogle Scholar
  4. 4.
    J.F. Habener, D. Powell, T.M. Murray, G.P. Mayer, and J.T. Potts, Jr., Parathyroid hormone: secretion and metabolism in vivo, Proc. Natl. Acad. Sci. USA 68:2986 (1971).PubMedCrossRefGoogle Scholar
  5. 5.
    J.C. Flueck, F.P. Di Bella, A.J. Edis, J.M. Kehrwald, and C.D. Arnaud, Immunoheterogeneity of parathyroid hormone in venous effluent serum from hyperfunctioning parathyroid glands, J. Clin. Invest. 60:1367 (1977).PubMedCrossRefGoogle Scholar
  6. 6.
    G.P. Mayer, J.A. Keaton, J.G. Hurst, and J.F. Habener, Effects of plasma calcium concentration on the relative proportion of hormone and carboxyl fragments in parathyroid venous blood. Endocrinology 104:1778 (1979).PubMedCrossRefGoogle Scholar
  7. 7.
    D.A. Hanley, K. Takatsuki, J.M. Sultan, A.B. Schneider, and L.M. Sherwood, Direct release of parathyroid hormone fragments from functioning bovine parathyroid glands in vitro, J. Clin. Invest. 62:1247 (1978).PubMedCrossRefGoogle Scholar
  8. 8.
    J.F. Habener, G.P. Mayer, P.C. Dee, and J.T. Potts, Jr., Metabolism of amino and carboxyl-sequence immunoreactive parathyroid hormone in the bovine: Evidence for peripheral cleavage of hormone, Metabolism 25:385 (1976).PubMedCrossRefGoogle Scholar
  9. 9.
    V.S. Fang, A.H. Tashjian, Jr., Studies on the role of the liver in the metabolism of parathyroid hormone. I. Effects of partial hepatectomy and incubation of the hormone with tissue homogenates, Endocrinology 90:1177 (1972).PubMedCrossRefGoogle Scholar
  10. 10.
    J.M. Canterbury, L.A. Bricker, J.S. Levey, P.L. Kozlovskis, E. Ruiz, J.E. Zull and E. Reiss, Metabolism of bovine parathyroid hormone: immunological and biological characteristics of fragments generated by liver perfusion, J. Clin. Invest. 55:1245 (1975).PubMedCrossRefGoogle Scholar
  11. 11.
    W.F. Neuman, M.W. Neuman, K. Lane, L. Miller, and P.J. Sammon, The metabolism of labeled parathyroid hormone. V. Collected biological studies, Calcif. Tissue Res. 18:271 (1975).CrossRefGoogle Scholar
  12. 12.
    W.F. Neuman and N. Schneider, The parathyroid hormone-sensitive adenylate cyclase system in plasma membranes of rat liver, Endocrinology 107:2082 (1980).PubMedCrossRefGoogle Scholar
  13. 13.
    P. D’Amour, G.V. Segre, S.I. Roth, and J.T. Potts, Jr., Analysis of parathyroid hormone and its fragments in rat tissues: chemical identification and microscopical localization, J. Clin. Invest. 63:89 (1979).PubMedCrossRefGoogle Scholar
  14. 14.
    G.V. Segre, A.S. Perkins, L.A. Witters, and J.T. Potts, Jr., Metabolism of parathyroid hormone by isolated rat Kupffer cells and hepatocytes,Google Scholar
  15. 15.
    K. Martin, K. Hruska, A. Greenwalt, S. Klahr, and E. Slatopolsky, Selective uptake of intact parathyroid hormone in the liver: differences between hepatic and renal uptake, J. Clin. Invest. 58:781 (1976).PubMedCrossRefGoogle Scholar
  16. 16.
    K.A. Hruska, A. Korkor, K. Martin, and E. Slatopolsky, Peripheral metabolism of intact parathyroid hormone: role of liver and kidney and the effect of chronic renal failure. J. Clin. Invest. 67:885 (1981).PubMedCrossRefGoogle Scholar
  17. 17.
    M.A. Mosely, N.H. Bell, S.R. Wagle, D.O. Allen, J. Ashmore, Parathyroid hormone stimulation of glucose and urea production in isolated liver cells, Am. J. Physiol. 227:1058 (1974).Google Scholar
  18. 18.
    K. Kurokawa, T. Ohno, and H. Rasmussen, Ionic control of renal gluconeogenesis. II. The effect on Ca2+ and H+ upon the response to parathyroid hormone and cyclic AMP. Biochem. Biophys. Acta 313:32 (1973).PubMedCrossRefGoogle Scholar
  19. 19.
    W.G. Guder and O.H. Wieland, Metabolism of isolated kidney tubules. Additive effects of parathyroid hormone and free-fatty acids on renal gluconeogenesis, Eur. J. Biochem. 31:69 (1972).PubMedCrossRefGoogle Scholar
  20. 20.
    K. Hruska, J. Blondin, R. Bass, J. Santiago, L. Thomas, P. Altsheler, K. Martin, and S. Klahr, Effect of intact parathyroid hormone on hepatic glucose release in the dog, J. Clin. Invest. 64:1016 (1979).PubMedCrossRefGoogle Scholar
  21. 21.
    D.A. Hems, C.S. Harmon, and P.D. Whitton, Inhibition by parathyroid hormone og glycogen synthesis in the perfused liver, Fed. Eur. Biochem. Soc. Lett. 58:167 (1975).CrossRefGoogle Scholar
  22. 22.
    S. Bevilacqua, E. Barret, E. Ferrannini, R. Gusberg, A. Stewart, D. Richardson, D. Smith, and R. DeFronzo, Lack of effect of parathyroid hormone on hepatic glucose metabolism in the dog, Metabolism 30:469 (1981).PubMedCrossRefGoogle Scholar
  23. 23.
    A.B. Chausmer, B.S. Sherman, S. Wallach, The effect of parathyroid hormone on hepatic cell transport of calcium, Endocrinology 90:663 (1972).PubMedCrossRefGoogle Scholar
  24. 24.
    R.A. Meyer, M.H. Meyer, Soft tissue phosphate loss accompanying the hyperphosphaturic effect of parathyroid hormone in rats, Endocrinology 94:1331 (1974).PubMedCrossRefGoogle Scholar
  25. 25.
    R.H. Rixon, J.F. Whitfield, Parathyroid hormone: a possible initiator of liver regeneration, Proc Soc Exp Biol Med 141:93 (1972).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Kevin Martin
    • 1
  • Keith Hruska
    • 1
  • Eduardo Slatopolsky
    • 1
  1. 1.Renal Division, Department of MedicineWashington University School of MedicineSt. LouisUSA

Personalised recommendations