Regulation Mechanisms of the Renal Phosphate Handling in Renal Failure — What is the Role of PTH?

  • H. Fleisch
  • J. Caverzasio
  • J.-P. Bonjour
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 151)


It has been known for a long time, that plasma inorganic phosphate (Pi) increases in renal failure. Since 1954 it has been realized that this increase occurs only at a glomerular filtration rate (GFR) below approximately 25 ml/min (1). Above this value plasma Pi remains constant in spite of a decrease in GFR and with an unchanged urinary Pi. As a consequence, fractional excretion (FE) will have to increase or conversely fractional tubular reabsorption (TRP%) must decrease (1).


Secondary Hyperparathyroidism Tubular Reabsorption Renal Handling Single Nephron Glomerular Filtration Rate Skeletal Resistance 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • H. Fleisch
    • 1
  • J. Caverzasio
    • 1
  • J.-P. Bonjour
    • 1
  1. 1.Department of PathophysiologyUniversity of BerneBerneSwitzerland

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