Effect of Parathyroid Hormone on Phospholipid Metabolism
Until recently it has been generally assumed that the major, if not the only, role of lipids in biological membranes is to provide a semipermeable barrier between intracellular and extracellular environments. Within the concept of membrane models, such as the “fluid-mosaic” model (1), active and facilitated transport and other events vital to cell or organelle function are mediated by proteins extending into or through the lipid bilayer with the possibility that lipids surrounding these proteins play some ill-defined regulatory role. However, it now appears that the view of lipids as inert building blocks of bio-membranes is incomplete, and that lipids may participate directly in many functional processes. Recent years have seen a dramatic increase in knowledge about the physicochemistry of membrane lipids mainly due to the development of sensitive calorimetric, X-ray and neutron diffraction and a variety of spectroscopic methods. A number of reviews have appeared recently (2–6).
KeywordsParathyroid Hormone Phosphatidic Acid Phosphatidic Acid Phospholipid Metabolism Parathyroid Hormone Secretion
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