Assessment of Biologically Active Parathyroid Hormone in Hyperparathyroid Man
The ability to measure peptide hormone levels in serum by radioimmunoassay (RIA) has revolutionized clinical endocrinology. It has become evident, however, that many peptide hormones circulate in multiple forms1, and that region-specific RIAs may fail to recognize one or more of these hormonal species. Furthermore, inasmuch as antigenic determinants bear no necessary relationship to regions of the hormone molecule required for biologic action, RIA measurements do not always reflect levels of biologically active hormone.
KeywordsParathyroid Hormone Adenylate Cyclase Parathyroid Gland Human Parathyroid Hormone Human Calcitonin
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