The Parathyroid Hormone Molecule: Biological Implications of Structure

  • Michael Rosenblatt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 151)


Analysis of the relation of structure to hormonal function for parathyroid hormone (PTH) has provided important insights into the physiological roles served by certain regions of the hormone molecule and the initial events and mechanisms by which hormonal messages are translated into physiological actions. Chemical synthesis of multiple segments of the hormone has now been achieved. Thus far approximately 80 analogues or fragments of PTH have been synthesized. Taken together, these synthetic fragments comprise (with considerable overlap) the entire structure of pre-proparathyroid hormone (Pre-ProPTH) and multiple analogues of the active core.


Parathyroid Hormone Rough Endoplasmic Reticulum Leader Sequence Agonist Property Human Parathyroid Hormone 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Michael Rosenblatt
    • 1
  1. 1.Endocrine UnitMassachusetts General HospitalBostonUSA

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