Abstract
Over the past 15 years, our knowledge has grown in two related fields: cellular calcium metabolism and calcium as intracellular messengers (1,2). This knowledge presents us with an apparent paradox. On the one hand is the evidence that the cell has developed an elaborate set of mechanisms for keeping intracellular calcium constant, and on the other that the cell employs changes in cytosolic calcium ion concentration to convey information from its surface to its interior. The paradox is how it can accomplish the latter in the face of the former.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Borle, A. (1981) Control, modulation and regulation of cell calcium. Rev. Physiol. Biochem. Pharmacol. 90: 14–152.
Rasmussen, H. and Waisman, D.M. (1981) The messenger function of calcium in endocrine systems. Bioch. Actions of Hormones VIII: 1–115.
Katz, B. Nerve, Muscle and Synapse. (1966) McGraw-Hill, New York.
Douglas, W.W. and Rubin, R.P. (1961) The role of calcium in the secondary response of the adrenal medulla to acetylcholine J. Physiol. London 159: 40–57.
Rasmussen, H. (1980) Calcium and cAMP in stimulus-response coupling. Ann. N.Y. Acad. Sci. 356: 346–353.
Rasmussen, H. Calcium and cAMP as Synarchic Messengers. John Wiley and Sons, New York (1981).
Berridge, M.J. (1975) The interaction of cyclic nucleotides and calcium in the control of cellular activity. Adv. Cyclic Nuc. Res. 6: 1–98.
O’Doherty, J., Youmans, S.J., Armstrong, W.McD and Stark, R.J. (1980) Calcium regulation during stimulus-secretion coupling: continuous measurement of intracellular calcium activities. Science 209: 510–513.
Borle, A. and Uchikawa, T. (1978) Effects of parathyroid hormone on the distribution and transport of calcium in cultural kidney cells. Endocrinology 102: 1725–1732.
Schanne, F.A.X., Kane, A.B., Young, E.E. and Farber, J.L. (1979) Calcium dependence of toxic cell death: A final common pathway. Science 206: 206–208.
Fleckenstein, A. (1974) Drug-induced changes in cardiac energy Adv. Cardiol. 12: 183–197.
Wrogemann, K. and Pena S.D.J. (1976) Mitochondrial calcium overload: a general mechanism for cell necrosis in muslce disease. Lancet I: 672:673.
Crouch, T.H. and Klee, C.B. (1980) Positive cooperative binding of calcium to bovine brain calmodulin. Biochemistry 19: 3692–3698.
Wang, J.H., Sharma, R.K., Huang, C.Y. and Chau, V. and Chock, P.B. (1980) On the mechanism of activation of cyclic nucleotide phosphodiesterase by calmodulin. Ann. N.Y. Acad. Sci. U.S.A. 356: 190–204.
Huang, C.Y., Chau, V., Chock, P.B., Wang, J.H. and Sharma, R. K. (1981) Mechanism of activation of cyclic nucleotide phosphodiesterase: requirement of the bindingof four Ca2+ to calmodulin for activation. Proc. Natl. Acad. Sci. USA 18: 871–874.
Wang, J.H., Teo, T.S. Ho, H.C. and Stevens, F.C. (1975) Bovine heart protein activator of cyclic nucleotide phosphodiesterase. Adv. Cyclic Nucl. Res. 5: 179–194.
Cheung, W.Y., Lynch, T.J., Wallace, R.W. and Tallant, E.C. (1981) cAMP renders Ca2+-dependent phosphodiesterase refractory to inhibition by a calmodulin-binding protein (cal-cineuria). J. Biol. Chem. 256: 4439–4443.
Penniston, J.T., Graf, E. and Itano, T. (1980) Calmodulin regulation of the Ca2+ pump of erythrocyte membranes. Ann. N.Y. Acad. Sci. 356: 245–257.
Vincenzi, F.F., Hinds, T.R. and Raess, B.V. (1980) Calmodulin and the plasma membrane calcium pump. Ann. N.Y. Acad. Sci. 256: 233–244.
Waisman, D.M., Gimble, J., Goodman, D.B.P. and Rasmussen, H. (1981) Studies of the Ca2+ transport mechanism of human inside-out plasma membrane vesicles. 1. Regulation of the Ca2+ pump by calmodulin. J. Biol. Chem. 256: 409–414.
Blumenthal, D.K. and Stuff, J.T. (1980) Activation of skeletal muscle myosin light kinase by calcium and calmodulin Biochemistry 19: 5608–5614.
Scharff, P. (1981) Calmodulin and its role in cellular activation. Cell Calcium 21: 1–28.
Berridge, M.J. and Lipke, H. (1979) Changes in calcium transport across Calliphora salivary glands induced by 5-hydroxytry-ptamine and cyclic nucleotides. J. Exp. Bio. 78: 137–158.
Nicholls, D.G. (1978) The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria. Biochem. J. 1979: 511–522.
Murphy, E. Catt, K. Rich, T.L. and Williamson, J.R. (1980). Hormonal effects on calcium homeostasis in isolated hepato-cytes. J. Bio. Chem. 255: 6600–6608.
Bronstrom, C.O. and Hunkeler, R.L. and Krebs, E.G. (1971). The regulation of skeletal muscle Phosphorylase kinase by Ca2+. J. Biol. Chem. 246: 1961–1967.
Shenolikar, S., Cohen, P.T.W., Cohen, P. Nairn, A.C. and Perry, S.V. (1979) The role of calmodulin in the structure and regulation of Phosphorylase kinase from rabbit skeletal muscle. Eur. J. Biochem. 100: 327–329.
Hartshorne, D.J. and Persechini, A.J. (1980) Phosphorylation of myosin as a regulatory component in smooth muscle. Ann. N.Y. Acad. Sci. 356: 130–141.
Adelstein, R.S., Conti, M.A. and Pato, M.D., (1980) Regulation of myosin light chain kinase by reversible phosphorylation and calcium-calmodulin. Ann. N.Y. Acad. Sci 356: 142–150.
Kerrick, W.G.L., Hoar, P.E. and Cassidy, P.S. (1980) Calcium-activated tension: the role of myosin light chain phosphorylation. Fed. Proc. 39: 1558–1563.
Silver, P.J., Holroyde, M.J., Solaro, J. and Disalvo, J. (1981) Ca2+, calmodulin and cyclic AMP-dependent modulation of actin-myosin interactions in aorta. Biochim. Biophys. Acta 674: 65–70.
Rasmussen, H. (1970) Cell communication, calcium ion and cyclic adenosine monophosphate. Science 170: 404–412.
Smith, S.B., White, H.D., Siegel, J.B. and Krebs, E.G. (1981) Cyclic AMP-dependent protein kinase I: cyclic nucleotide binding, structural changes, and release of catalytic sub-units. Proc.Natl. Acad. Sci. USA 78: 1591–1595.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Rasmussen, H. (1982). Calcium as Intracellular Messenger in Hormone Action. In: Massry, S.G., Letteri, J.M., Ritz, E. (eds) Regulation of Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 151. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4259-5_52
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4259-5_52
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4261-8
Online ISBN: 978-1-4684-4259-5
eBook Packages: Springer Book Archive